ID   NST1_PICST              Reviewed;        1234 AA.
AC   A3LYI0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Stress response protein NST1;
GN   Name=NST1; ORFNames=PICST_68216;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: May act as a negative regulator of salt tolerance.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NST1 family. {ECO:0000305}.
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DR   EMBL; CP000500; ABN67640.2; -; Genomic_DNA.
DR   RefSeq; XP_001385669.2; XM_001385632.1.
DR   AlphaFoldDB; A3LYI0; -.
DR   SMR; A3LYI0; -.
DR   STRING; 4924.XP_001385669.2; -.
DR   PRIDE; A3LYI0; -.
DR   EnsemblFungi; ABN67640; ABN67640; PICST_68216.
DR   GeneID; 4840313; -.
DR   KEGG; pic:PICST_68216; -.
DR   eggNOG; ENOG502QSSK; Eukaryota.
DR   HOGENOM; CLU_003284_0_0_1; -.
DR   InParanoid; A3LYI0; -.
DR   OMA; HEVRDIN; -.
DR   OrthoDB; 1180340at2759; -.
DR   Proteomes; UP000002258; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025279; NST1.
DR   Pfam; PF13945; NST1; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Reference proteome; Stress response.
FT   CHAIN           1..1234
FT                   /note="Stress response protein NST1"
FT                   /id="PRO_0000324458"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          513..608
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          661..816
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          924..945
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1214..1234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          633..826
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        19..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..175
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..270
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        513..542
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        556..583
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        584..608
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        661..809
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1234 AA;  137852 MW;  791EEF58376DF44D CRC64;
     MSDTTDSTSR FRLGDDIHFS YDNQSQPTTS ESPAPSSSNK KKKKKANKKH KQPVEATLNN
     PEDDYPTSRV IKQAPNGDVI VESLDDEASH QNQENHRHHH QYTNIWDSAS IEEQENLKSF
     WESLDESSKM ELVKIDKKSI MEIFKNETKA NNQSHHGHGA NGTSSASGAN SAANANPVTP
     SCACKYCGRR STIIEDELEN IYDNHFDDII DFIHEIRDIN DLNALPGLLF GGFHMLEEEH
     KLQKRQQRMK HKRDHPASQN HTENPEVHGE HPHVQPQNFV NSRAPADSIN TSVVDNRTPY
     PVAAGSIGAK QLQHQQQLQQ QLQQQQLRQL QQQLQQEQNV HSQPQQSLQM QQQLNENDLP
     GGNTSDLAKH LEKMSLEDKK GEYTNERKIF QKLLDPKLVE VLDKVDFEKV KSGNYVGSAS
     QANLFQRADC LREIVRDLHK ADKTQLEQGL SFLKNISSIF SNSKTPFPAD VTSNPRNFSS
     KFNDQLSNFA EDLLKNDGNS FIEMMESLSE SRTAREDLLK DPTKKDAQAW VDEDDNNDSK
     RPDASTVKQP SQEYEYYEES EEDEEELSEE DEDDADDNGL NEDDDLVQDG HHDDSASDTE
     SEISEEEKMQ EIRRLFLIQV IKLFQERLKS AYKEKLSEDR TQKLIEELEA EENAKKEREL
     KKLKQKEKAK EKKRLQQLAK EEEKKKKEEE QRAKEEELKQ KQEALKADQR RRKEEAKLKR
     EEEKKKRIEE LKRKEEEHKK KVEAQQKKEE EAKKLKEERK KKAEEERKKK EEEKRQKELL
     KKQKEEERER LKLEAEENER LEKEQQELQE LQESQNQLEL ESAQLPAELA EEINASPDSF
     SPTKNHLLEQ LYQARPSSVS GPTTISPPIQ FTPEAVPPVA AVSSVVPSVV PISPALSGAI
     LNGTGSPNSR NAMLYGSSAQ AQLPNGLNSS TSNMSPWSSK SRLNSTSGAS LQSNLFQPQL
     SASGFSPFND FSTPATSAGI GSVNVNAPLA STAVEPLAGA NNGGVWNPST TSSRNNSIWS
     NTPNLNNASI WGNTLPSLAG GAGAGASTPS AAHTLPNSAP LASDNELIQV AAYNTFQMLQ
     NSNQLEFGAA PLMKLFSGVK LLLGNNALTI NQLLSSCDST SVYHFEFVYD DFGTVTHVKV
     NFNNGGLAQS LQSQAAPTLL NNTLATSAAG LRSSPPPGLG TKASTGSVPL SQFRFNINDA
     NSPLLSNLGD WSSGNNSTNA NGNSSNGGSR GLWN