ID   NST1_YARLI              Reviewed;         889 AA.
AC   Q6CBW0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Stress response protein NST1;
GN   Name=NST1; OrderedLocusNames=YALI0C15070g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May act as a negative regulator of salt tolerance.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NST1 family. {ECO:0000305}.
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DR   EMBL; CR382129; CAG82165.1; -; Genomic_DNA.
DR   RefSeq; XP_501852.1; XM_501852.1.
DR   AlphaFoldDB; Q6CBW0; -.
DR   STRING; 4952.CAG82165; -.
DR   EnsemblFungi; CAG82165; CAG82165; YALI0_C15070g.
DR   GeneID; 2909348; -.
DR   KEGG; yli:YALI0C15070g; -.
DR   VEuPathDB; FungiDB:YALI0_C15070g; -.
DR   HOGENOM; CLU_324715_0_0_1; -.
DR   InParanoid; Q6CBW0; -.
DR   Proteomes; UP000001300; Chromosome C.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025279; NST1.
DR   Pfam; PF13945; NST1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Reference proteome; Stress response.
FT   CHAIN           1..889
FT                   /note="Stress response protein NST1"
FT                   /id="PRO_0000324462"
FT   REGION          31..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          291..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          380..610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          648..701
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          363..581
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        202..229
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        237..253
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..320
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..336
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..397
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        405..579
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        590..607
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        654..676
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   889 AA;  100257 MW;  CC1B4588BAC17363 CRC64;
     MEKAIYSKDG KRVINLKSRE TFKTENVSFE WGADDSKPKS KKKKKRKSKG QQVIIDSIDL
     DERSIVHGVM EAKMKAEKLA RLKKSVNDTF PPSPASGLSP SMERQTIKYF WLSLTSEQRR
     ELVQVEKEAV LNKMKRQQKN TCECDICGRK RVAIEQELET LYADYYKELD ALAESKDLPL
     LPLPSMGFFQ ADDVLRGGHQ DGNTTEELSE ATNRLSIAPA TTATTRPLPQ NLGKEIDEEG
     DTEEDEPYGF EEGEDVQSLD VSSVADDLLT NDGKKFIEMM ERLAEKRAGR IEEIRDGEDE
     EPVVVEDDND DEEYENDSDY SDYSSEYSQT GESLTADQRM EEGRRMFQIF AARMFEQRVL
     HAYKQSVAAQ VKAELQQMEE EKKTLDLEKE ARDQQRRERK KEKKRAQKAI KEEEKRKAAA
     EREEREKREA EEAERLRLEA ERKQQEKERE KAARKAASEA KQKARQEEQA RLAREKEEKR
     LARIREMEER MRLAKEKEER EKEELRARQQ QEEDERREKE RLEEERIENE RLEAERIENE
     RLEKEREQQR LEEEKERQRI KEEREKQKLE EEREKRASMS IPLSKPLPGK TQIPASQPGT
     SLGGLQQPVP QAAPVAPVAM MPQSPSPQLP PGLTQHVAQS QILLDRLTPD PTSRMTPERH
     TPSPGSTTSN AKTLLDSLLR PAQGPSTPPP GPGTPRSSIS HVAPVGAIGT IGSPGQVNQQ
     PLHVHPGHMN HLSQGPVTPG QVNHPVGNIG HVGNVGTVGS IGLVNPPEQP ISQPISPPST
     TLPISQHRFD PWNSSYSGIA SSSTPGNRLW GSSGEVPGNV IRQAALDAYE ELHKNGSIDC
     NGFVNSRALQ NTAQKYSSTG QGFGVSELFK ACQGSFDIVG GLMKPRGGL