NSUN7_MACFA
ID NSUN7_MACFA Reviewed; 702 AA.
AC Q4R7Q1; Q4R8B7; Q95LR3; Q9GMM6;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=Putative methyltransferase NSUN7;
DE EC=2.1.1.-;
DE AltName: Full=NOL1/NOP2/Sun domain family member 7;
GN Name=NSUN7; ORFNames=QnpA-16118, QtsA-12871, QtsA-14680, QtsA-19789;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Parietal cortex;
RX PubMed=11574149; DOI=10.1016/s0378-1119(01)00665-5;
RA Osada N., Hida M., Kususda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.;
RT "Assignment of 118 novel cDNAs of cynomolgus monkey brain to human
RT chromosomes.";
RL Gene 275:31-37(2001).
RN [2]
RP ERRATUM OF PUBMED:11574149.
RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K., Kususda J.;
RL Gene 278:267-267(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 378-702.
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
CC -!- FUNCTION: May have S-adenosyl-L-methionine-dependent methyl-transferase
CC activity. {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q4R7Q1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4R7Q1-2; Sequence=VSP_025981;
CC Name=3;
CC IsoId=Q4R7Q1-3; Sequence=VSP_025980;
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000255|PROSITE-ProRule:PRU01023}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB64523.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB047909; BAB12330.1; -; mRNA.
DR EMBL; AB168540; BAE00655.1; -; mRNA.
DR EMBL; AB168764; BAE00871.1; -; mRNA.
DR EMBL; AB071129; BAB64523.1; ALT_SEQ; mRNA.
DR AlphaFoldDB; Q4R7Q1; -.
DR SMR; Q4R7Q1; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR001678; MeTrfase_RsmB/NOP2.
DR InterPro; IPR042620; NSUN7.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14663; PTHR14663; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Methyltransferase; Reference proteome; RNA-binding;
KW S-adenosyl-L-methionine; Transferase.
FT CHAIN 1..702
FT /note="Putative methyltransferase NSUN7"
FT /id="PRO_0000289239"
FT REGION 522..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 424
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01023"
FT VAR_SEQ 1..548
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11574149"
FT /id="VSP_025980"
FT VAR_SEQ 1..276
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_025981"
FT CONFLICT 357
FT /note="P -> L (in Ref. 1; BAE00655)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 702 AA; 79246 MW; BC8CA2A66F2D7583 CRC64;
MLNSTGELEF SNEEDAEIIS QLTSLALSDG KSSAGAPEKT GYPDSVYVMA ANIFQGIRIE
KSAQKVLIKY GNEPLRSFSE SEDQSFQRLS YELAFSALKY QDILETILID SCIFPSTTIP
DRKFQTRVLS DNEESISEVQ EVENLLNSFK IKLAAALARC RIKHDALSIY HILPETVRKQ
ELRASTLPLY AWINTCKISP EEVYNNLKRR GYNKVKSVLH IDDKVFAVDQ HCYDVLIFPS
HLKNDLINID LFKDYKLIFQ DKSRSLAVHS VKALLNMDDD ILMVNTGSWY TVAHMSILTN
NNTSKVFVCG VQSQAKDPDL KTLFTKMGCK NIEILRETFI NIESKDHRLQ KVKVILPLPR
CSGLGVSNPV EFILNEHEDT EFLKDHSQGG ISVDKLHILA QQQYEQLTHA MKFTKAQAVV
YCTCSVCPEE NEAVVKKALE FQDLGNKVQL YRLSPPVLPL CSLKEIQLST DKFFRMEPSE
ITNGCFLSIL TRERDPSETV SVKDVLARAA AKGLLDGIEL GKSSKREKKK KKSKTSLTKA
ATTDNGIQMK IAEFLNRETK ASANLSETVT KPSLPQKNTA QVGASSQTRK HKLAPHPAVP
TFMKNTCPSR PRERQTHFIR PRPEDRMVAL KPIEIVLPPV FMPFSSPQGI RSRMPTQHLY
CHWVAPKPLV PTCLPTPSLS RKGEKPKDDT RSSLLRPPRR WL
