NT2NA_HUMAN
ID NT2NA_HUMAN Reviewed; 236 AA.
AC Q7Z3S9; Q5BKT8; Q5VTG9; Q5XG84; Q6P192; Q8NC23; Q8WUQ9; Q96FY1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Notch homolog 2 N-terminal-like protein A {ECO:0000303|PubMed:29856954, ECO:0000303|PubMed:29856955};
DE AltName: Full=Notch homolog 2 N-terminal-like protein {ECO:0000303|PubMed:14673143};
GN Name=NOTCH2NLA {ECO:0000303|PubMed:29856954, ECO:0000303|PubMed:29856955,
GN ECO:0000312|HGNC:HGNC:31862};
GN Synonyms=N2N {ECO:0000303|PubMed:14673143},
GN NOTCH2NL {ECO:0000312|HGNC:HGNC:31862};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP ILE-158.
RC TISSUE=Brain, Eye, Liver, Ovary, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INTERACTION WITH ELANE, SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING BY
RP ELANE, AND TISSUE SPECIFICITY.
RX PubMed=14673143; DOI=10.1128/mcb.24.1.58-70.2004;
RA Duan Z., Li F.-Q., Wechsler J., Meade-White K., Williams K., Benson K.F.,
RA Horwitz M.;
RT "A novel notch protein, N2N, targeted by neutrophil elastase and implicated
RT in hereditary neutropenia.";
RL Mol. Cell. Biol. 24:58-70(2004).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH NOTCH2, TISSUE
RP SPECIFICITY, AND INVOLVEMENT IN CHROMOSOME 1Q21.1 DELETION/DUPLICATION
RP SYNDROME.
RX PubMed=29856954; DOI=10.1016/j.cell.2018.03.051;
RA Fiddes I.T., Lodewijk G.A., Mooring M., Bosworth C.M., Ewing A.D.,
RA Mantalas G.L., Novak A.M., van den Bout A., Bishara A., Rosenkrantz J.L.,
RA Lorig-Roach R., Field A.R., Haeussler M., Russo L., Bhaduri A.,
RA Nowakowski T.J., Pollen A.A., Dougherty M.L., Nuttle X., Addor M.C.,
RA Zwolinski S., Katzman S., Kriegstein A., Eichler E.E., Salama S.R.,
RA Jacobs F.M.J., Haussler D.;
RT "Human-specific NOTCH2NL genes affect Notch signaling and cortical
RT neurogenesis.";
RL Cell 173:1356-1369(2018).
RN [7]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=29856955; DOI=10.1016/j.cell.2018.03.067;
RA Suzuki I.K., Gacquer D., Van Heurck R., Kumar D., Wojno M., Bilheu A.,
RA Herpoel A., Lambert N., Cheron J., Polleux F., Detours V.,
RA Vanderhaeghen P.;
RT "Human-specific NOTCH2NL genes expand cortical neurogenesis through
RT Delta/Notch regulation.";
RL Cell 173:1370-1384(2018).
RN [8]
RP FUNCTION.
RX PubMed=29561261; DOI=10.7554/elife.32332;
RA Florio M., Heide M., Pinson A., Brandl H., Albert M., Winkler S.,
RA Wimberger P., Huttner W.B., Hiller M.;
RT "Evolution and cell-type specificity of human-specific genes preferentially
RT expressed in progenitors of fetal neocortex.";
RL Elife 7:0-0(2018).
CC -!- FUNCTION: Human-specific protein that promotes neural progenitor
CC proliferation and evolutionary expansion of the brain neocortex by
CC regulating the Notch signaling pathway (PubMed:29856954,
CC PubMed:29856955, PubMed:29561261). Able to promote neural progenitor
CC self-renewal, possibly by down-regulating neuronal differentiation
CC genes, thereby delaying the differentiation of neuronal progenitors and
CC leading to an overall final increase in neuronal production
CC (PubMed:29856954). Acts by enhancing the Notch signaling pathway via
CC two different mechanisms that probably work in parallel to reach the
CC same effect (PubMed:29856954). Enhances Notch signaling pathway in a
CC non-cell-autonomous manner via direct interaction with NOTCH2
CC (PubMed:29856954). Also promotes Notch signaling pathway in a cell-
CC autonomous manner through inhibition of cis DLL1-NOTCH2 interactions,
CC which promotes neuronal differentiation (By similarity).
CC {ECO:0000250|UniProtKB:P0DPK3, ECO:0000269|PubMed:29561261,
CC ECO:0000269|PubMed:29856954, ECO:0000269|PubMed:29856955}.
CC -!- SUBUNIT: Interacts with ELANE (PubMed:14673143). Interacts with NOTCH2
CC (PubMed:29856954). Interacts with DLL1; the interaction is direct (By
CC similarity). {ECO:0000250|UniProtKB:P0DPK3,
CC ECO:0000269|PubMed:14673143, ECO:0000269|PubMed:29856954}.
CC -!- INTERACTION:
CC Q7Z3S9; Q96HD9: ACY3; NbExp=3; IntAct=EBI-945833, EBI-3916242;
CC Q7Z3S9; P82987: ADAMTSL3; NbExp=3; IntAct=EBI-945833, EBI-10221726;
CC Q7Z3S9; Q6ZMM2-2: ADAMTSL5; NbExp=3; IntAct=EBI-945833, EBI-10254938;
CC Q7Z3S9; Q3MIX3: ADCK5; NbExp=4; IntAct=EBI-945833, EBI-3923548;
CC Q7Z3S9; P43353: ALDH3B1; NbExp=3; IntAct=EBI-945833, EBI-2558314;
CC Q7Z3S9; P09923: ALPI; NbExp=4; IntAct=EBI-945833, EBI-1052631;
CC Q7Z3S9; P29972: AQP1; NbExp=3; IntAct=EBI-945833, EBI-745213;
CC Q7Z3S9; P55064: AQP5; NbExp=3; IntAct=EBI-945833, EBI-746103;
CC Q7Z3S9; Q99856: ARID3A; NbExp=3; IntAct=EBI-945833, EBI-5458244;
CC Q7Z3S9; Q9BZE9: ASPSCR1; NbExp=3; IntAct=EBI-945833, EBI-1993677;
CC Q7Z3S9; Q7Z3C6: ATG9A; NbExp=3; IntAct=EBI-945833, EBI-727146;
CC Q7Z3S9; A8KA13: BCL6B; NbExp=3; IntAct=EBI-945833, EBI-10174813;
CC Q7Z3S9; P62952: BLCAP; NbExp=4; IntAct=EBI-945833, EBI-3895726;
CC Q7Z3S9; A8K571: BMP7; NbExp=3; IntAct=EBI-945833, EBI-10174327;
CC Q7Z3S9; Q6NUJ2: C11orf87; NbExp=3; IntAct=EBI-945833, EBI-6660291;
CC Q7Z3S9; A6NFR6-4: C5orf60; NbExp=3; IntAct=EBI-945833, EBI-10173955;
CC Q7Z3S9; Q8N4G4: CA6; NbExp=4; IntAct=EBI-945833, EBI-10265475;
CC Q7Z3S9; Q9Y2V2: CARHSP1; NbExp=3; IntAct=EBI-945833, EBI-718719;
CC Q7Z3S9; Q8NEC5: CATSPER1; NbExp=4; IntAct=EBI-945833, EBI-744545;
CC Q7Z3S9; Q8TAB7: CCDC26; NbExp=3; IntAct=EBI-945833, EBI-10271580;
CC Q7Z3S9; Q8TC90: CCER1; NbExp=4; IntAct=EBI-945833, EBI-746041;
CC Q7Z3S9; Q04900: CD164; NbExp=3; IntAct=EBI-945833, EBI-2115896;
CC Q7Z3S9; Q8N619: CDK5R1; NbExp=3; IntAct=EBI-945833, EBI-10266998;
CC Q7Z3S9; Q8TAM4: CDK5R1; NbExp=3; IntAct=EBI-945833, EBI-10271838;
CC Q7Z3S9; Q8TCT0: CERK; NbExp=3; IntAct=EBI-945833, EBI-10274247;
CC Q7Z3S9; Q9NX63: CHCHD3; NbExp=3; IntAct=EBI-945833, EBI-743375;
CC Q7Z3S9; Q8NE62: CHDH; NbExp=3; IntAct=EBI-945833, EBI-7127986;
CC Q7Z3S9; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-945833, EBI-741528;
CC Q7Z3S9; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-945833, EBI-947551;
CC Q7Z3S9; P07510: CHRNG; NbExp=5; IntAct=EBI-945833, EBI-9008836;
CC Q7Z3S9; P07510-2: CHRNG; NbExp=3; IntAct=EBI-945833, EBI-11979451;
CC Q7Z3S9; P57739: CLDN2; NbExp=3; IntAct=EBI-945833, EBI-751440;
CC Q7Z3S9; A5D8T8: CLEC18A; NbExp=3; IntAct=EBI-945833, EBI-10173491;
CC Q7Z3S9; P27658: COL8A1; NbExp=3; IntAct=EBI-945833, EBI-747133;
CC Q7Z3S9; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-945833, EBI-739773;
CC Q7Z3S9; Q9UGL9: CRCT1; NbExp=5; IntAct=EBI-945833, EBI-713677;
CC Q7Z3S9; Q02930-3: CREB5; NbExp=3; IntAct=EBI-945833, EBI-10192698;
CC Q7Z3S9; P09603: CSF1; NbExp=3; IntAct=EBI-945833, EBI-2872294;
CC Q7Z3S9; P09228: CST2; NbExp=3; IntAct=EBI-945833, EBI-8832659;
CC Q7Z3S9; Q9H4G1: CST9L; NbExp=3; IntAct=EBI-945833, EBI-3923092;
CC Q7Z3S9; P08311: CTSG; NbExp=3; IntAct=EBI-945833, EBI-5462635;
CC Q7Z3S9; Q9UBR2: CTSZ; NbExp=4; IntAct=EBI-945833, EBI-8636823;
CC Q7Z3S9; Q6I9S7: CXCL5; NbExp=3; IntAct=EBI-945833, EBI-10249885;
CC Q7Z3S9; Q96LJ7: DHRS1; NbExp=3; IntAct=EBI-945833, EBI-746300;
CC Q7Z3S9; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-945833, EBI-9679045;
CC Q7Z3S9; O96015: DNAL4; NbExp=3; IntAct=EBI-945833, EBI-742362;
CC Q7Z3S9; Q92608: DOCK2; NbExp=3; IntAct=EBI-945833, EBI-448771;
CC Q7Z3S9; P52797: EFNA3; NbExp=3; IntAct=EBI-945833, EBI-722730;
CC Q7Z3S9; O60573: EIF4E2; NbExp=3; IntAct=EBI-945833, EBI-398610;
CC Q7Z3S9; O15197-2: EPHB6; NbExp=3; IntAct=EBI-945833, EBI-10182490;
CC Q7Z3S9; O00519: FAAH; NbExp=3; IntAct=EBI-945833, EBI-1389829;
CC Q7Z3S9; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-945833, EBI-741626;
CC Q7Z3S9; Q8NEG0: FAM71C; NbExp=3; IntAct=EBI-945833, EBI-752049;
CC Q7Z3S9; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-945833, EBI-10247271;
CC Q7Z3S9; O95363: FARS2; NbExp=3; IntAct=EBI-945833, EBI-2513774;
CC Q7Z3S9; P48023: FASLG; NbExp=3; IntAct=EBI-945833, EBI-495538;
CC Q7Z3S9; Q96D16: FBXL18; NbExp=3; IntAct=EBI-945833, EBI-744419;
CC Q7Z3S9; Q969U6: FBXW5; NbExp=3; IntAct=EBI-945833, EBI-741068;
CC Q7Z3S9; Q99853: FOXB1; NbExp=3; IntAct=EBI-945833, EBI-3916225;
CC Q7Z3S9; O43559: FRS3; NbExp=3; IntAct=EBI-945833, EBI-725515;
CC Q7Z3S9; O14764: GABRD; NbExp=3; IntAct=EBI-945833, EBI-744352;
CC Q7Z3S9; P23769: GATA2; NbExp=4; IntAct=EBI-945833, EBI-2806671;
CC Q7Z3S9; P55040: GEM; NbExp=3; IntAct=EBI-945833, EBI-744104;
CC Q7Z3S9; Q9NXC2: GFOD1; NbExp=3; IntAct=EBI-945833, EBI-8799578;
CC Q7Z3S9; P09681: GIP; NbExp=3; IntAct=EBI-945833, EBI-8588553;
CC Q7Z3S9; P43220: GLP1R; NbExp=3; IntAct=EBI-945833, EBI-7466542;
CC Q7Z3S9; O76003: GLRX3; NbExp=3; IntAct=EBI-945833, EBI-374781;
CC Q7Z3S9; Q6IB77: GLYAT; NbExp=3; IntAct=EBI-945833, EBI-715463;
CC Q7Z3S9; P04899: GNAI2; NbExp=3; IntAct=EBI-945833, EBI-353997;
CC Q7Z3S9; Q9Y223: GNE; NbExp=4; IntAct=EBI-945833, EBI-4291090;
CC Q7Z3S9; P09211: GSTP1; NbExp=3; IntAct=EBI-945833, EBI-353467;
CC Q7Z3S9; Q9Y5Q8: GTF3C5; NbExp=3; IntAct=EBI-945833, EBI-1045409;
CC Q7Z3S9; P02008: HBZ; NbExp=4; IntAct=EBI-945833, EBI-719843;
CC Q7Z3S9; P08631: HCK; NbExp=3; IntAct=EBI-945833, EBI-346340;
CC Q7Z3S9; V9HW60: HEL-S-182mP; NbExp=3; IntAct=EBI-945833, EBI-10180762;
CC Q7Z3S9; V9HWJ5: HEL-S-90n; NbExp=3; IntAct=EBI-945833, EBI-10330335;
CC Q7Z3S9; A4FTV9: HIST1H2AK; NbExp=3; IntAct=EBI-945833, EBI-10173457;
CC Q7Z3S9; P49639: HOXA1; NbExp=3; IntAct=EBI-945833, EBI-740785;
CC Q7Z3S9; P37235: HPCAL1; NbExp=3; IntAct=EBI-945833, EBI-749311;
CC Q7Z3S9; O75506: HSBP1; NbExp=4; IntAct=EBI-945833, EBI-748664;
CC Q7Z3S9; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-945833, EBI-3918847;
CC Q7Z3S9; Q96MM6: HSPA12B; NbExp=3; IntAct=EBI-945833, EBI-10291310;
CC Q7Z3S9; Q9NZL4: HSPBP1; NbExp=4; IntAct=EBI-945833, EBI-356763;
CC Q7Z3S9; P10809: HSPD1; NbExp=3; IntAct=EBI-945833, EBI-352528;
CC Q7Z3S9; Q14773-3: ICAM4; NbExp=3; IntAct=EBI-945833, EBI-10233928;
CC Q7Z3S9; P13284: IFI30; NbExp=3; IntAct=EBI-945833, EBI-2868897;
CC Q7Z3S9; P31785: IL2RG; NbExp=4; IntAct=EBI-945833, EBI-80475;
CC Q7Z3S9; Q92835: INPP5D; NbExp=3; IntAct=EBI-945833, EBI-1380477;
CC Q7Z3S9; P05107: ITGB2; NbExp=7; IntAct=EBI-945833, EBI-300173;
CC Q7Z3S9; L7RT22: ITGB5; NbExp=3; IntAct=EBI-945833, EBI-10178729;
CC Q7Z3S9; Q15040: JOSD1; NbExp=3; IntAct=EBI-945833, EBI-2510602;
CC Q7Z3S9; Q96SI1: KCTD15; NbExp=3; IntAct=EBI-945833, EBI-715783;
CC Q7Z3S9; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-945833, EBI-6426443;
CC Q7Z3S9; O60259: KLK8; NbExp=3; IntAct=EBI-945833, EBI-3915857;
CC Q7Z3S9; P35900: KRT20; NbExp=3; IntAct=EBI-945833, EBI-742094;
CC Q7Z3S9; P78385: KRT83; NbExp=3; IntAct=EBI-945833, EBI-10221390;
CC Q7Z3S9; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-945833, EBI-10217483;
CC Q7Z3S9; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-945833, EBI-10172150;
CC Q7Z3S9; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-945833, EBI-10172290;
CC Q7Z3S9; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-945833, EBI-10171774;
CC Q7Z3S9; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-945833, EBI-10172052;
CC Q7Z3S9; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-945833, EBI-10176379;
CC Q7Z3S9; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-945833, EBI-10176396;
CC Q7Z3S9; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-945833, EBI-10241252;
CC Q7Z3S9; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-945833, EBI-3957672;
CC Q7Z3S9; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-945833, EBI-9996449;
CC Q7Z3S9; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-945833, EBI-10302392;
CC Q7Z3S9; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-945833, EBI-739863;
CC Q7Z3S9; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-945833, EBI-10172511;
CC Q7Z3S9; Q9BYR0: KRTAP4-7; NbExp=3; IntAct=EBI-945833, EBI-10302547;
CC Q7Z3S9; Q6L8G9: KRTAP5-6; NbExp=4; IntAct=EBI-945833, EBI-10250562;
CC Q7Z3S9; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-945833, EBI-3958099;
CC Q7Z3S9; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-945833, EBI-1044640;
CC Q7Z3S9; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-945833, EBI-10185730;
CC Q7Z3S9; Q5T7P3: LCE1B; NbExp=6; IntAct=EBI-945833, EBI-10245913;
CC Q7Z3S9; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-945833, EBI-10246750;
CC Q7Z3S9; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-945833, EBI-10245291;
CC Q7Z3S9; Q5T5B0: LCE3E; NbExp=4; IntAct=EBI-945833, EBI-10245456;
CC Q7Z3S9; Q7Z4I7-5: LIMS2; NbExp=3; IntAct=EBI-945833, EBI-10257651;
CC Q7Z3S9; O14910: LIN7A; NbExp=3; IntAct=EBI-945833, EBI-2513988;
CC Q7Z3S9; Q96FQ7: LINC00526; NbExp=3; IntAct=EBI-945833, EBI-10286106;
CC Q7Z3S9; P25791: LMO2; NbExp=3; IntAct=EBI-945833, EBI-739696;
CC Q7Z3S9; Q8TBB1: LNX1; NbExp=4; IntAct=EBI-945833, EBI-739832;
CC Q7Z3S9; Q17RD9: LOC200261; NbExp=3; IntAct=EBI-945833, EBI-10239007;
CC Q7Z3S9; Q496Y0: LONRF3; NbExp=3; IntAct=EBI-945833, EBI-2690768;
CC Q7Z3S9; O75427: LRCH4; NbExp=3; IntAct=EBI-945833, EBI-718707;
CC Q7Z3S9; Q6PJG9: LRFN4; NbExp=3; IntAct=EBI-945833, EBI-7910762;
CC Q7Z3S9; O60336: MAPKBP1; NbExp=3; IntAct=EBI-945833, EBI-947402;
CC Q7Z3S9; Q6IPE9: MARK4; NbExp=3; IntAct=EBI-945833, EBI-10250211;
CC Q7Z3S9; O15232: MATN3; NbExp=3; IntAct=EBI-945833, EBI-6262458;
CC Q7Z3S9; P08582-2: MELTF; NbExp=3; IntAct=EBI-945833, EBI-10195914;
CC Q7Z3S9; Q4ZG74: MGC13033; NbExp=3; IntAct=EBI-945833, EBI-10241963;
CC Q7Z3S9; Q9NV56: MRGBP; NbExp=3; IntAct=EBI-945833, EBI-399076;
CC Q7Z3S9; Q9NQ50: MRPL40; NbExp=3; IntAct=EBI-945833, EBI-1053902;
CC Q7Z3S9; Q13330: MTA1; NbExp=3; IntAct=EBI-945833, EBI-714236;
CC Q7Z3S9; Q9BW11: MXD3; NbExp=4; IntAct=EBI-945833, EBI-741574;
CC Q7Z3S9; P50539-3: MXI1; NbExp=3; IntAct=EBI-945833, EBI-10211940;
CC Q7Z3S9; Q15742: NAB2; NbExp=3; IntAct=EBI-945833, EBI-8641936;
CC Q7Z3S9; Q8IW45: NAXD; NbExp=3; IntAct=EBI-945833, EBI-8650724;
CC Q7Z3S9; Q92692: NECTIN2; NbExp=3; IntAct=EBI-945833, EBI-718419;
CC Q7Z3S9; Q9NQS3: NECTIN3; NbExp=4; IntAct=EBI-945833, EBI-2826725;
CC Q7Z3S9; Q9Y3R4: NEU2; NbExp=6; IntAct=EBI-945833, EBI-10327976;
CC Q7Z3S9; P48645: NMU; NbExp=3; IntAct=EBI-945833, EBI-10210351;
CC Q7Z3S9; P48146: NPBWR2; NbExp=3; IntAct=EBI-945833, EBI-10210114;
CC Q7Z3S9; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-945833, EBI-748927;
CC Q7Z3S9; P16860: NPPB; NbExp=4; IntAct=EBI-945833, EBI-747044;
CC Q7Z3S9; Q6NSM0: NR1D2; NbExp=4; IntAct=EBI-945833, EBI-10250949;
CC Q7Z3S9; Q9Y5Y2: NUBP2; NbExp=3; IntAct=EBI-945833, EBI-1048886;
CC Q7Z3S9; Q99571: P2RX4; NbExp=3; IntAct=EBI-945833, EBI-2828248;
CC Q7Z3S9; Q9H1Q7: PCED1A; NbExp=3; IntAct=EBI-945833, EBI-748452;
CC Q7Z3S9; Q96HM7: PCED1B; NbExp=3; IntAct=EBI-945833, EBI-1222622;
CC Q7Z3S9; Q92824: PCSK5; NbExp=3; IntAct=EBI-945833, EBI-751290;
CC Q7Z3S9; O76083: PDE9A; NbExp=4; IntAct=EBI-945833, EBI-742764;
CC Q7Z3S9; Q7Z2X4: PID1; NbExp=3; IntAct=EBI-945833, EBI-10256685;
CC Q7Z3S9; Q96S52: PIGS; NbExp=3; IntAct=EBI-945833, EBI-2908273;
CC Q7Z3S9; O43688: PLPP2; NbExp=3; IntAct=EBI-945833, EBI-722017;
CC Q7Z3S9; Q9NRQ2: PLSCR4; NbExp=5; IntAct=EBI-945833, EBI-769257;
CC Q7Z3S9; Q8NAT1: POMGNT2; NbExp=3; IntAct=EBI-945833, EBI-10269044;
CC Q7Z3S9; P54646: PRKAA2; NbExp=3; IntAct=EBI-945833, EBI-1383852;
CC Q7Z3S9; Q8WWY3: PRPF31; NbExp=6; IntAct=EBI-945833, EBI-1567797;
CC Q7Z3S9; P11908: PRPS2; NbExp=3; IntAct=EBI-945833, EBI-4290895;
CC Q7Z3S9; P25786: PSMA1; NbExp=3; IntAct=EBI-945833, EBI-359352;
CC Q7Z3S9; Q969U7: PSMG2; NbExp=3; IntAct=EBI-945833, EBI-723276;
CC Q7Z3S9; P43115-12: PTGER3; NbExp=3; IntAct=EBI-945833, EBI-10234038;
CC Q7Z3S9; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-945833, EBI-7199479;
CC Q7Z3S9; Q9H3S7: PTPN23; NbExp=4; IntAct=EBI-945833, EBI-724478;
CC Q7Z3S9; P15151: PVR; NbExp=4; IntAct=EBI-945833, EBI-3919694;
CC Q7Z3S9; Q9Y2K5-2: R3HDM2; NbExp=3; IntAct=EBI-945833, EBI-10326419;
CC Q7Z3S9; Q8TBN0: RAB3IL1; NbExp=4; IntAct=EBI-945833, EBI-743796;
CC Q7Z3S9; O60896: RAMP3; NbExp=3; IntAct=EBI-945833, EBI-720447;
CC Q7Z3S9; Q96PM5: RCHY1; NbExp=4; IntAct=EBI-945833, EBI-947779;
CC Q7Z3S9; Q6P9E2: RECK; NbExp=3; IntAct=EBI-945833, EBI-10253121;
CC Q7Z3S9; P07949: RET; NbExp=3; IntAct=EBI-945833, EBI-2480756;
CC Q7Z3S9; P07949-2: RET; NbExp=3; IntAct=EBI-945833, EBI-4423689;
CC Q7Z3S9; O15211: RGL2; NbExp=3; IntAct=EBI-945833, EBI-712355;
CC Q7Z3S9; P62857: RPS28; NbExp=3; IntAct=EBI-945833, EBI-353027;
CC Q7Z3S9; Q86UN2: RTN4RL1; NbExp=3; IntAct=EBI-945833, EBI-10258951;
CC Q7Z3S9; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-945833, EBI-748391;
CC Q7Z3S9; O00560: SDCBP; NbExp=3; IntAct=EBI-945833, EBI-727004;
CC Q7Z3S9; Q8WWX9: SELENOM; NbExp=3; IntAct=EBI-945833, EBI-10277687;
CC Q7Z3S9; Q9C0C4: SEMA4C; NbExp=3; IntAct=EBI-945833, EBI-10303490;
CC Q7Z3S9; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-945833, EBI-10313866;
CC Q7Z3S9; A1A5C7: SLC22A23; NbExp=4; IntAct=EBI-945833, EBI-10171756;
CC Q7Z3S9; Q9UHI7: SLC23A1; NbExp=3; IntAct=EBI-945833, EBI-1759386;
CC Q7Z3S9; Q9UBX3: SLC25A10; NbExp=4; IntAct=EBI-945833, EBI-750394;
CC Q7Z3S9; P12236: SLC25A6; NbExp=3; IntAct=EBI-945833, EBI-356254;
CC Q7Z3S9; Q9NP91: SLC6A20; NbExp=3; IntAct=EBI-945833, EBI-10311198;
CC Q7Z3S9; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-945833, EBI-455078;
CC Q7Z3S9; P49901: SMCP; NbExp=4; IntAct=EBI-945833, EBI-750494;
CC Q7Z3S9; Q9H4F8: SMOC1; NbExp=4; IntAct=EBI-945833, EBI-2801103;
CC Q7Z3S9; O95863: SNAI1; NbExp=4; IntAct=EBI-945833, EBI-1045459;
CC Q7Z3S9; Q6RVD6: SPATA8; NbExp=3; IntAct=EBI-945833, EBI-8635958;
CC Q7Z3S9; Q9UQ90: SPG7; NbExp=3; IntAct=EBI-945833, EBI-717201;
CC Q7Z3S9; P20155: SPINK2; NbExp=3; IntAct=EBI-945833, EBI-10200479;
CC Q7Z3S9; O43609: SPRY1; NbExp=5; IntAct=EBI-945833, EBI-3866665;
CC Q7Z3S9; O75716: STK16; NbExp=3; IntAct=EBI-945833, EBI-749295;
CC Q7Z3S9; Q8IV04: TBC1D10C; NbExp=3; IntAct=EBI-945833, EBI-10261452;
CC Q7Z3S9; Q7L2K0: TEDC2; NbExp=3; IntAct=EBI-945833, EBI-8465456;
CC Q7Z3S9; Q9BT49: THAP7; NbExp=4; IntAct=EBI-945833, EBI-741350;
CC Q7Z3S9; Q5TEJ8: THEMIS2; NbExp=4; IntAct=EBI-945833, EBI-2806032;
CC Q7Z3S9; Q9GZM7-3: TINAGL1; NbExp=3; IntAct=EBI-945833, EBI-10303636;
CC Q7Z3S9; Q08117: TLE5; NbExp=3; IntAct=EBI-945833, EBI-717810;
CC Q7Z3S9; Q86TG1: TMEM150A; NbExp=3; IntAct=EBI-945833, EBI-2799342;
CC Q7Z3S9; Q9H6L2: TMEM231; NbExp=3; IntAct=EBI-945833, EBI-10307654;
CC Q7Z3S9; Q96HV5: TMEM41A; NbExp=3; IntAct=EBI-945833, EBI-10288884;
CC Q7Z3S9; Q96KP6: TNIP3; NbExp=3; IntAct=EBI-945833, EBI-2509913;
CC Q7Z3S9; Q07912: TNK2; NbExp=3; IntAct=EBI-945833, EBI-603457;
CC Q7Z3S9; Q4VB56: TNP2; NbExp=3; IntAct=EBI-945833, EBI-10241829;
CC Q7Z3S9; P14373: TRIM27; NbExp=3; IntAct=EBI-945833, EBI-719493;
CC Q7Z3S9; Q8IWZ5: TRIM42; NbExp=6; IntAct=EBI-945833, EBI-5235829;
CC Q7Z3S9; Q9Y260: TRPV6; NbExp=3; IntAct=EBI-945833, EBI-750052;
CC Q7Z3S9; O14817: TSPAN4; NbExp=4; IntAct=EBI-945833, EBI-8652667;
CC Q7Z3S9; Q86UY0: TXNDC5; NbExp=3; IntAct=EBI-945833, EBI-2825190;
CC Q7Z3S9; Q9BRU9: UTP23; NbExp=3; IntAct=EBI-945833, EBI-5457544;
CC Q7Z3S9; Q9UBK9: UXT; NbExp=4; IntAct=EBI-945833, EBI-357355;
CC Q7Z3S9; Q64LD2: WDR25; NbExp=3; IntAct=EBI-945833, EBI-744560;
CC Q7Z3S9; Q06250: WT1-AS; NbExp=3; IntAct=EBI-945833, EBI-10223946;
CC Q7Z3S9; Q9UBD3: XCL2; NbExp=3; IntAct=EBI-945833, EBI-10319095;
CC Q7Z3S9; Q9GZM5: YIPF3; NbExp=4; IntAct=EBI-945833, EBI-743787;
CC Q7Z3S9; Q9BQ24: ZFYVE21; NbExp=3; IntAct=EBI-945833, EBI-2849569;
CC Q7Z3S9; P17041: ZNF32; NbExp=3; IntAct=EBI-945833, EBI-1965483;
CC Q7Z3S9; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-945833, EBI-740727;
CC Q7Z3S9; Q8NDP4: ZNF439; NbExp=3; IntAct=EBI-945833, EBI-747580;
CC Q7Z3S9; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-945833, EBI-726439;
CC Q7Z3S9; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-945833, EBI-740232;
CC Q7Z3S9; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-945833, EBI-745520;
CC Q7Z3S9; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-945833, EBI-6427977;
CC Q7Z3S9; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-945833, EBI-16429014;
CC Q7Z3S9; Q5BKY6; NbExp=3; IntAct=EBI-945833, EBI-10243533;
CC Q7Z3S9; Q9NWL9; NbExp=3; IntAct=EBI-945833, EBI-10315054;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14673143,
CC ECO:0000269|PubMed:29856954}. Cytoplasm {ECO:0000269|PubMed:14673143}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7Z3S9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z3S9-2; Sequence=VSP_033896;
CC Name=3;
CC IsoId=Q7Z3S9-3; Sequence=VSP_033895;
CC -!- TISSUE SPECIFICITY: Widely expressed with higher levels in leukocytes
CC and lymph nodes (PubMed:14673143). Expressed in radial glia neural stem
CC cells during cortical development (PubMed:29856954).
CC {ECO:0000269|PubMed:14673143, ECO:0000269|PubMed:29856954}.
CC -!- DEVELOPMENTAL STAGE: Expressed at low levels at 7-9 gestational weeks
CC and then increases at later stages, including in the non-cortical plate
CC region at gestational week 21, containing the outer-subventricular zone
CC (PubMed:29856955). Expressed at lower level than NOTCH2NLB
CC (PubMed:29856955). {ECO:0000269|PubMed:29856955}.
CC -!- PTM: Cleaved by ELANE. {ECO:0000269|PubMed:14673143}.
CC -!- DISEASE: Note=Defects in NOTCH2NLA may be a cause of chromosome 1q21.1
CC deletion/duplication syndrome (PubMed:29856954). Deletions of NOTCH2NL
CC (NOTCH2NLA, NOTCH2NLB and/or NOTCH2NLC) are present in patients
CC affected by microcephaly, whereas macrocephaly is observed in patients
CC with NOTCH2NL duplications (PubMed:29856954).
CC {ECO:0000269|PubMed:29856954}.
CC -!- SIMILARITY: Belongs to the NOTCH family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH84572.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC11381.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK075065; BAC11381.1; ALT_INIT; mRNA.
DR EMBL; BX537434; CAD97676.1; -; mRNA.
DR EMBL; AL592307; CAH73993.1; -; Genomic_DNA.
DR EMBL; AL592307; CAH73994.1; -; Genomic_DNA.
DR EMBL; BC010154; AAH10154.3; -; mRNA.
DR EMBL; BC019835; AAH19835.1; -; mRNA.
DR EMBL; BC065219; AAH65219.2; -; mRNA.
DR EMBL; BC084572; AAH84572.1; ALT_INIT; mRNA.
DR EMBL; BC090943; AAH90943.1; -; mRNA.
DR CCDS; CCDS72880.1; -. [Q7Z3S9-1]
DR RefSeq; NP_982283.2; NM_203458.4. [Q7Z3S9-1]
DR RefSeq; XP_006711766.1; XM_006711703.3.
DR RefSeq; XP_006726418.1; XM_006726355.3.
DR RefSeq; XP_016855384.1; XM_016999895.1.
DR RefSeq; XP_016855385.1; XM_016999896.1.
DR RefSeq; XP_016855386.1; XM_016999897.1.
DR RefSeq; XP_016855387.1; XM_016999898.1.
DR RefSeq; XP_016858537.1; XM_017003048.1.
DR RefSeq; XP_016858538.1; XM_017003049.1.
DR RefSeq; XP_016858539.1; XM_017003050.1.
DR RefSeq; XP_016858540.1; XM_017003051.1.
DR AlphaFoldDB; Q7Z3S9; -.
DR SMR; Q7Z3S9; -.
DR BioGRID; 132802; 377.
DR DIP; DIP-47315N; -.
DR IntAct; Q7Z3S9; 250.
DR MINT; Q7Z3S9; -.
DR GlyGen; Q7Z3S9; 1 site.
DR BioMuta; NOTCH2NL; -.
DR DMDM; 74750065; -.
DR EPD; Q7Z3S9; -.
DR jPOST; Q7Z3S9; -.
DR MassIVE; Q7Z3S9; -.
DR MaxQB; Q7Z3S9; -.
DR PaxDb; Q7Z3S9; -.
DR PeptideAtlas; Q7Z3S9; -.
DR PRIDE; Q7Z3S9; -.
DR ProteomicsDB; 69079; -. [Q7Z3S9-1]
DR ProteomicsDB; 69080; -. [Q7Z3S9-2]
DR ProteomicsDB; 69081; -. [Q7Z3S9-3]
DR TopDownProteomics; Q7Z3S9-3; -. [Q7Z3S9-3]
DR Antibodypedia; 72493; 61 antibodies from 17 providers.
DR DNASU; 388677; -.
DR Ensembl; ENST00000362074.7; ENSP00000354929.6; ENSG00000264343.7. [Q7Z3S9-1]
DR Ensembl; ENST00000579793.6; ENSP00000476330.2; ENSG00000264343.7. [Q7Z3S9-2]
DR Ensembl; ENST00000686973.1; ENSP00000510377.1; ENSG00000264343.7. [Q7Z3S9-1]
DR Ensembl; ENST00000687833.1; ENSP00000508809.1; ENSG00000264343.7. [Q7Z3S9-1]
DR Ensembl; ENST00000692119.1; ENSP00000510366.1; ENSG00000264343.7. [Q7Z3S9-1]
DR GeneID; 388677; -.
DR KEGG; hsa:388677; -.
DR MANE-Select; ENST00000362074.8; ENSP00000354929.6; NM_203458.6; NP_982283.2.
DR UCSC; uc031utx.2; human. [Q7Z3S9-1]
DR CTD; 388677; -.
DR DisGeNET; 388677; -.
DR GeneCards; NOTCH2NLA; -.
DR HGNC; HGNC:31862; NOTCH2NLA.
DR HPA; ENSG00000264343; Low tissue specificity.
DR MIM; 618023; gene.
DR neXtProt; NX_Q7Z3S9; -.
DR OpenTargets; ENSG00000264343; -.
DR PharmGKB; PA134983899; -.
DR VEuPathDB; HostDB:ENSG00000264343; -.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000167308; -.
DR HOGENOM; CLU_004826_3_0_1; -.
DR InParanoid; Q7Z3S9; -.
DR OrthoDB; 1033311at2759; -.
DR PhylomeDB; Q7Z3S9; -.
DR PathwayCommons; Q7Z3S9; -.
DR SignaLink; Q7Z3S9; -.
DR BioGRID-ORCS; 100996717; 0 hits in 4 CRISPR screens.
DR BioGRID-ORCS; 100996763; 0 hits in 4 CRISPR screens.
DR BioGRID-ORCS; 388677; 517 hits in 989 CRISPR screens.
DR ChiTaRS; NOTCH2NLB; human.
DR Pharos; Q7Z3S9; Tbio.
DR PRO; PR:Q7Z3S9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q7Z3S9; protein.
DR Bgee; ENSG00000264343; Expressed in corpus callosum and 101 other tissues.
DR Genevisible; Q7Z3S9; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IPI:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0021987; P:cerebral cortex development; IDA:UniProtKB.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IDA:UniProtKB.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR Pfam; PF00008; EGF; 3.
DR Pfam; PF07645; EGF_CA; 1.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Calcium; Cytoplasm; Developmental protein;
KW Differentiation; Disulfide bond; EGF-like domain; Glycoprotein;
KW Notch signaling pathway; Reference proteome; Repeat; Secreted.
FT CHAIN 1..236
FT /note="Notch homolog 2 N-terminal-like protein A"
FT /id="PRO_0000337103"
FT DOMAIN 1..24
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 25..63
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 66..104
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 105..141
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 143..180
FT /note="EGF-like 5; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 182..219
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 14..23
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 29..40
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 34..51
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 53..62
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 70..82
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 76..92
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 94..103
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 109..120
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 114..129
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 131..140
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 147..159
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 153..168
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 170..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 186..197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 191..207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT VAR_SEQ 1
FT /note="M -> MCRDGYEPCVNEGM (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033895"
FT VAR_SEQ 212..236
FT /note="ETVRRGTELWERDREVWNGKEHDEN -> ATWPIFPKLLSLQEKESYC (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033896"
FT VARIANT 67
FT /note="S -> P (in dbSNP:rs10910779)"
FT /id="VAR_043601"
FT VARIANT 158
FT /note="T -> I (in dbSNP:rs8002)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_043602"
FT VARIANT 196
FT /note="T -> S (in dbSNP:rs4649852)"
FT /id="VAR_043603"
FT VARIANT 226
FT /note="E -> Q (in dbSNP:rs1053710)"
FT /id="VAR_043604"
FT CONFLICT 19
FT /note="L -> S (in Ref. 1; BAC11381)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 236 AA; 25835 MW; 2DF01880A22814C9 CRC64;
MCVTYHNGTG YCKCPEGFLG EYCQHRDPCE KNRCQNGGTC VAQAMLGKAT CRCASGFTGE
DCQYSTSHPC FVSRPCLNGG TCHMLSRDTY ECTCQVGFTG KECQWTDACL SHPCANGSTC
TTVANQFSCK CLTGFTGQKC ETDVNECDIP GHCQHGGTCL NLPGSYQCQC LQGFTGQYCD
SLYVPCAPSP CVNGGTCRQT GDFTFECNCL PETVRRGTEL WERDREVWNG KEHDEN
