NT53_DROME
ID NT53_DROME Reviewed; 484 AA.
AC P82149;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Lethal(2)neighbour of tid protein 2;
DE AltName: Full=NOT53;
GN Name=l(2)not2;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Apxo;
RX PubMed=9373138; DOI=10.1016/s0378-1119(97)00373-9;
RA Kurzik-Dumke U., Kaymer M., Gundacker D., Debes A., Labitzke K.;
RT "Gene within gene configuration and expression of the Drosophila
RT melanogaster genes lethal(2) neighbour of tid [l(2)not] and lethal(2)
RT relative of tid.";
RL Gene 200:45-58(1997).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed only in embryos.
CC -!- MISCELLANEOUS: In strains Harvich and Apxo, there are 2 genes which
CC code for l(2)not protein. They differ in their C-terminus.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 58 family.
CC {ECO:0000305}.
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DR EMBL; Y10074; CAA71168.1; -; Genomic_DNA.
DR EMBL; X95244; CAA64533.1; -; Genomic_DNA.
DR AlphaFoldDB; P82149; -.
DR SMR; P82149; -.
DR FlyBase; FBgn0011297; l(2)not.
DR VEuPathDB; VectorBase:FBgn0011297; -.
DR HOGENOM; CLU_035382_3_0_1; -.
DR SignaLink; P82149; -.
DR ExpressionAtlas; P82149; baseline and differential.
DR Genevisible; P82149; DM.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0052925; F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR InterPro; IPR007873; Glycosyltransferase_ALG3.
DR PANTHER; PTHR12646; PTHR12646; 1.
DR Pfam; PF05208; ALG3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Endoplasmic reticulum; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..484
FT /note="Lethal(2)neighbour of tid protein 2"
FT /id="PRO_0000080569"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 484 AA; 55458 MW; 0E1142BED20EA9D2 CRC64;
MAPPKAASHR PAVRRKKSGT LVDSILDKYL NVRFFKYLLL EPAALPIVGL FVLLAELVIN
VVVIQRVPYT EIDWVAYMQE CEGFLNGTTN YSLLRGDTGP LVYPAAFVYI YSALYYVTSH
GTNVRLAQYI FAGIYLLQLA LVLRLYSKSR KVPPYVLVLS AFTSYRIHSI YVLRLFNDPV
AVLLLYAALN LFLDRRWTLG STFFSLAVGV KMNILLFAPA LLLFYLANLG LLRTILQLAV
CGVIQLLLGA PFLLTHPVEY LRGSFDLGRI FEHKWTVNYR FLSRDVFENR TFHVSLLGLH
LLLLLAFAKP TWTFFQSYVR LRRIEDQLQP QIAQQNLELK AQKRPKKVEK DKDKDQKKFT
TEQQSFLKAF EKSLQKASGG KATPAPAQAE PERYGIHFDR CTQLALLPFF LCNLVGVACS
RSLHYQFYVW YFHSLPYLAW STPYSLGVRC LILGLIEYCW NTYPSTNFSS AALHFTHIIP
PYQL
