ID   NT56_DROVI              Reviewed;         526 AA.
AC   Q24332;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Lethal(2)neighbour of Tid protein;
DE   AltName: Full=NOT58;
GN   Name=l(2)not; Synonyms=not;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RX   PubMed=9434170; DOI=10.1016/s0378-1119(97)00528-3;
RA   Kaymer M., Debes A., Kress H., Kurzik-Dumke U.;
RT   "Sequence, molecular organization and products of the Drosophila virilis
RT   homologs of the D. melanogaster nested genes lethal(2) tumorous imaginal
RT   discs [l(2)tid] and lethal(2) neighbour of tid [l(2)not].";
RL   Gene 204:91-103(1997).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed only during embryonic stages.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 58 family.
CC       {ECO:0000305}.
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DR   EMBL; Y07700; CAA68963.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q24332; -.
DR   STRING; 7244.FBpp0232720; -.
DR   CAZy; GT58; Glycosyltransferase Family 58.
DR   eggNOG; KOG2762; Eukaryota.
DR   ChiTaRS; Not1; fly.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000030; F:mannosyltransferase activity; IEA:InterPro.
DR   GO; GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; IEA:EnsemblMetazoa.
DR   InterPro; IPR007873; Glycosyltransferase_ALG3.
DR   PANTHER; PTHR12646; PTHR12646; 1.
DR   Pfam; PF05208; ALG3; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Endoplasmic reticulum; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..526
FT                   /note="Lethal(2)neighbour of Tid protein"
FT                   /id="PRO_0000080570"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   526 AA;  61280 MW;  C71A91DD0861A397 CRC64;
     MAPPRTNNRP VTRRKKPSNL LLLLKEKYVN WNFIKYLAFE PAALPIVSVL IVLAEAVINV
     LVIQRVPYTE IDWKAYMQEC EGFLNGTTNY SLLRGDTGPL VYPAAFVYIY SGLYYLTGQG
     TNVRLAQYIF ACIYLLQMCL VLRLYTKSRK VPPYVLVLSA FTSYRIHSIY VLRLFNDPVA
     ILLLYAALNL FLDQRWTLGS ICYSLAVGVK MNILLFAPAL LLFYLANLGV LRTLVQLTIC
     AVLQLFIGAP FLRTHPMEYL RGSFDLGRIF EHKWTVNYRF LSKELFEQRE FHLVLLALHL
     LLLLCFAKPT WTFFRSYLRL REVQQQIVPQ ILHKNREQQN QAKIQAKKSK QLVEQQQEEE
     DEQLSAEQKS FLKAFERSLQ QSTGQKSLEP HLNQKQEQYD IYFEPCTQLA LLPFFLCNFI
     GVACARSLHY QFYIWYFHSL PYLVWSTPYS LGVRYLILGI IEYCWNTYPS TMESSIALHL
     CHLILLVGVA RHVYRILRLN ATVKQQQRQE QSTLQNGQPK TSKKSQ