ID   NT5D1_BOVIN             Reviewed;         452 AA.
AC   Q2TBU5;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=5'-nucleotidase domain-containing protein 1;
DE            EC=3.1.3.-;
GN   Name=NT5DC1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 5'(3')-deoxyribonucleotidase family.
CC       {ECO:0000305}.
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DR   EMBL; BC109642; AAI09643.1; -; mRNA.
DR   RefSeq; NP_001098955.1; NM_001105485.1.
DR   AlphaFoldDB; Q2TBU5; -.
DR   SMR; Q2TBU5; -.
DR   STRING; 9913.ENSBTAP00000004003; -.
DR   PaxDb; Q2TBU5; -.
DR   PRIDE; Q2TBU5; -.
DR   Ensembl; ENSBTAT00000004003; ENSBTAP00000004003; ENSBTAG00000003076.
DR   GeneID; 100125914; -.
DR   KEGG; bta:100125914; -.
DR   CTD; 221294; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003076; -.
DR   VGNC; VGNC:32294; NT5DC1.
DR   eggNOG; KOG2469; Eukaryota.
DR   GeneTree; ENSGT00940000155676; -.
DR   HOGENOM; CLU_029966_0_0_1; -.
DR   InParanoid; Q2TBU5; -.
DR   OMA; NWHQLHA; -.
DR   OrthoDB; 875136at2759; -.
DR   TreeFam; TF325912; -.
DR   Proteomes; UP000009136; Chromosome 9.
DR   Bgee; ENSBTAG00000003076; Expressed in spermatid and 106 other tissues.
DR   ExpressionAtlas; Q2TBU5; baseline and differential.
DR   GO; GO:0008253; F:5'-nucleotidase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR008380; HAD-SF_hydro_IG_5-nucl.
DR   InterPro; IPR023214; HAD_sf.
DR   PANTHER; PTHR12103; PTHR12103; 1.
DR   Pfam; PF05761; 5_nucleotid; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Hydrolase; Magnesium; Metal-binding; Reference proteome.
FT   CHAIN           1..452
FT                   /note="5'-nucleotidase domain-containing protein 1"
FT                   /id="PRO_0000247221"
FT   REGION          339..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..360
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        16
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        18
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         16
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         18
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         313
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         171
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5TFE4"
SQ   SEQUENCE   452 AA;  51365 MW;  5214C683A6B47B8D CRC64;
     MAQHFSLAAC DVVGFDLDHT LCCYNLPESA RLIYNSFAQF LVKEKGYDKG LLTVTPEDWD
     FCCKGLALDL EDGNFIKLAD NGTVLRASHG TKMLSAEALA EEFGRKEWKH FMPDTGMAFR
     SGKYYFYDNY FDLPGALLCA RVVDSLTKQN NGQKPFDFWK DIVAGIQHNY KMSAFKENCG
     IYFPEIKRDP GKYLHTCPES VKKWLRQLKN AGKILMLITS SHSDYCRLLC QYILGNDFED
     LFDIVITNAL KPGFFSHLPS QRPFRTLEND EEREALPFLD KPGWYSQGNA VHLYELLKKM
     TGKPEPKVVY FGDSMHSDIF PACHYSNWET VLILEELRGD KDGKPEESEP EEKKGKYEGS
     KAKPLNTSSK KWGSFFIDSV SGLENREDSL VYTWSCKRIS AYSTIAIPSI EAIAELPLDY
     KFTRFSSNNS KTAGYYPNPP LVLSNAGKLT AK