ID   NT5D2_RAT               Reviewed;         553 AA.
AC   Q6Q0N3; Q5M7U9;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=5'-nucleotidase domain-containing protein 2;
DE            EC=3.1.3.-;
GN   Name=Nt5dc2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Wistar;
RX   PubMed=15326124; DOI=10.1167/iovs.04-0302;
RA   Ahmed F., Torrado M., Zinovieva R.D., Senatorov V.V., Wistow G.,
RA   Tomarev S.I.;
RT   "Gene expression profile of the rat eye iridocorneal angle: NEIBank
RT   expressed sequence tag analysis.";
RL   Invest. Ophthalmol. Vis. Sci. 45:3081-3090(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- TISSUE SPECIFICITY: Expressed in eye iridocorneal angle.
CC       {ECO:0000269|PubMed:15326124}.
CC   -!- SIMILARITY: Belongs to the 5'(3')-deoxyribonucleotidase family.
CC       {ECO:0000305}.
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DR   EMBL; AY569011; AAS75314.1; -; mRNA.
DR   EMBL; BC088431; AAH88431.1; -; mRNA.
DR   RefSeq; NP_001009271.1; NM_001009271.1.
DR   AlphaFoldDB; Q6Q0N3; -.
DR   SMR; Q6Q0N3; -.
DR   IntAct; Q6Q0N3; 3.
DR   STRING; 10116.ENSRNOP00000024840; -.
DR   iPTMnet; Q6Q0N3; -.
DR   PhosphoSitePlus; Q6Q0N3; -.
DR   jPOST; Q6Q0N3; -.
DR   PaxDb; Q6Q0N3; -.
DR   PRIDE; Q6Q0N3; -.
DR   GeneID; 290558; -.
DR   KEGG; rno:290558; -.
DR   UCSC; RGD:1305524; rat.
DR   CTD; 64943; -.
DR   RGD; 1305524; Nt5dc2.
DR   VEuPathDB; HostDB:ENSRNOG00000018358; -.
DR   eggNOG; KOG2470; Eukaryota.
DR   HOGENOM; CLU_017845_5_1_1; -.
DR   InParanoid; Q6Q0N3; -.
DR   OMA; WARYHEM; -.
DR   OrthoDB; 858908at2759; -.
DR   PhylomeDB; Q6Q0N3; -.
DR   TreeFam; TF323990; -.
DR   PRO; PR:Q6Q0N3; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000018358; Expressed in pancreas and 18 other tissues.
DR   Genevisible; Q6Q0N3; RN.
DR   GO; GO:0008253; F:5'-nucleotidase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR008380; HAD-SF_hydro_IG_5-nucl.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR016695; Pur_nucleotidase.
DR   PANTHER; PTHR12103; PTHR12103; 1.
DR   Pfam; PF05761; 5_nucleotid; 1.
DR   PIRSF; PIRSF017434; Purine_5'-nucleotidase; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR02244; HAD-IG-Ncltidse; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Magnesium; Metal-binding; Reference proteome.
FT   CHAIN           1..553
FT                   /note="5'-nucleotidase domain-containing protein 2"
FT                   /id="PRO_0000247225"
FT   REGION          26..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        106
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        108
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         106
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         108
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         391
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        186
FT                   /note="D -> Y (in Ref. 1; AAS75314)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        190
FT                   /note="V -> D (in Ref. 1; AAS75314)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        329
FT                   /note="V -> G (in Ref. 1; AAS75314)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        431
FT                   /note="L -> M (in Ref. 1; AAS75314)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        494
FT                   /note="R -> G (in Ref. 1; AAS75314)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        506
FT                   /note="L -> F (in Ref. 1; AAS75314)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        546
FT                   /note="L -> F (in Ref. 1; AAS75314)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   553 AA;  63653 MW;  2946FE7A21312D7B CRC64;
     MAGAGLRAAA RRWLLCGGQG GPRAASSSPS CPGCGPPGPG AHCPSTPRSA PADGADLSAH
     LWARYQDMRR LVHDLLPPEV CSLLNPAAIY ANNEISLSDV EVYGFDYDYT LAQYADALHP
     EIFSAARDIL IEHYKYPEGI RKYDYDPSFA IRGLHYDIQK SLLMKIDAFH YVQLGTAYRG
     LQPVPDDEVV DLYGGTQHIP LYQMSGFYGK GPSIKQFMDI FSLPEMALLS CVVDYFLGHG
     LEFDQVHLYK DVTDAIRDVH VKGLMYQWIE QDMEKYILRG DETFAVLSRL VAHGKQLFLI
     TNSPFSFVDK GMRHMVGPDW RQLFDVVIVQ ADKPNFFTDR RKPFRKLDEK GSLHWDRITR
     LEKGKIYRQG NLFDFLRLTE WRGPRVLYFG DHLYSDLADL MLRHGWRTGA IIPELEREIR
     IINTEQYMHS LTWQQALTGL LERMQTYQDA ESRQVLATWM KERQELRCIT KALFNAQFGS
     IFRTFHNPTY FSRRLVRFSD LYMASLSCLL NYSVDFTFYP RRTPLQHEAP LWMDQLCTGC
     MKTPFLGDMA HIR