ID   NT5D4_HUMAN             Reviewed;         428 AA.
AC   Q86YG4;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=5'-nucleotidase domain-containing protein 4;
GN   Name=NT5DC4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the 5'(3')-deoxyribonucleotidase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH41437.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC041437; AAH41437.1; ALT_INIT; mRNA.
DR   CCDS; CCDS86877.1; -.
DR   AlphaFoldDB; Q86YG4; -.
DR   SMR; Q86YG4; -.
DR   BioGRID; 129986; 1.
DR   IntAct; Q86YG4; 1.
DR   STRING; 9606.ENSP00000330247; -.
DR   DEPOD; NT5DC4; -.
DR   iPTMnet; Q86YG4; -.
DR   PhosphoSitePlus; Q86YG4; -.
DR   BioMuta; NT5DC4; -.
DR   jPOST; Q86YG4; -.
DR   MassIVE; Q86YG4; -.
DR   MaxQB; Q86YG4; -.
DR   PaxDb; Q86YG4; -.
DR   PeptideAtlas; Q86YG4; -.
DR   PRIDE; Q86YG4; -.
DR   ProteomicsDB; 70413; -.
DR   Antibodypedia; 63788; 59 antibodies from 13 providers.
DR   Ensembl; ENST00000327581.4; ENSP00000330247.4; ENSG00000144130.12.
DR   UCSC; uc002tid.4; human.
DR   GeneCards; NT5DC4; -.
DR   HGNC; HGNC:27678; NT5DC4.
DR   HPA; ENSG00000144130; Tissue enhanced (testis).
DR   MalaCards; NT5DC4; -.
DR   neXtProt; NX_Q86YG4; -.
DR   VEuPathDB; HostDB:ENSG00000144130; -.
DR   eggNOG; KOG2469; Eukaryota.
DR   HOGENOM; CLU_017845_3_1_1; -.
DR   PhylomeDB; Q86YG4; -.
DR   TreeFam; TF315266; -.
DR   PathwayCommons; Q86YG4; -.
DR   SignaLink; Q86YG4; -.
DR   ChiTaRS; NT5DC4; human.
DR   Pharos; Q86YG4; Tdark.
DR   PRO; PR:Q86YG4; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q86YG4; protein.
DR   Bgee; ENSG00000144130; Expressed in left testis and 99 other tissues.
DR   Genevisible; Q86YG4; HS.
DR   GO; GO:0008253; F:5'-nucleotidase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR008380; HAD-SF_hydro_IG_5-nucl.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR016695; Pur_nucleotidase.
DR   PANTHER; PTHR12103; PTHR12103; 1.
DR   Pfam; PF05761; 5_nucleotid; 1.
DR   PIRSF; PIRSF017434; Purine_5'-nucleotidase; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR02244; HAD-IG-Ncltidse; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Magnesium; Metal-binding; Reference proteome.
FT   CHAIN           1..428
FT                   /note="5'-nucleotidase domain-containing protein 4"
FT                   /id="PRO_0000344218"
FT   ACT_SITE        22
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        24
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         22
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         24
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         317
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   428 AA;  48951 MW;  A2598591D92FF8EE CRC64;
     MPAWIFVNRS LALGKIRCFG FDMDYTLAAY KSPAYEALTF ELLLERLVCI GYPHEILRYT
     YDPTFPTRRL VFDELYGNLL KVDAHGNVLL GAYGFTFLSE AEIWSFYPSK FIQRDDLQCF
     YILNMLFNLP ETYLYACLVD FFSGCSRYTN CDTGYQHGNL FMSFRSLFQD VTDAMNNIHQ
     SGCLKKTLED LEKYVKKDPR LPILLGKMKE VGKVFLATNS SYNYTNAIMT YLFSISEAEA
     SGRPWRSYFD LIVVDTQKPH FFAEGLVLRQ VNTDSGKLHV GTSTGPHQHC AVYSGGSSDM
     VCELLGVRGM DILYIGDHIF GDILKSKKRQ GWRTCLVVPE LSWELDIWAQ EKERLEELKR
     LDTHLADIYQ HMDGSSCELQ VINFTKREIQ MPHESVVEQE QANLDPASCL LSCNQRSLPA
     KSCLSSAI