NT8F7_MOUSE
ID NT8F7_MOUSE Reviewed; 227 AA.
AC E0CYR6;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=N-acetyltransferase family 8 member 7 {ECO:0000312|MGI:MGI:3782661};
DE EC=2.3.1.48 {ECO:0000269|PubMed:25123547};
GN Name=Nat8f7 {ECO:0000312|MGI:MGI:3782661};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305}
RP FUNCTION, AND CATALYTIC ACTIVITY.
RX PubMed=25123547; DOI=10.1038/srep06076;
RA Karmodiya K., Anamika K., Muley V., Pradhan S.J., Bhide Y., Galande S.;
RT "Camello, a novel family of Histone Acetyltransferases that acetylate
RT histone H4 and is essential for zebrafish development.";
RL Sci. Rep. 4:6076-6076(2014).
CC -!- FUNCTION: Has histone acetyltransferase activity in vitro, with
CC specificity for histone H4. {ECO:0000269|PubMed:25123547}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC Evidence={ECO:0000269|PubMed:25123547};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the camello family. {ECO:0000305}.
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DR EMBL; AC162313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS57434.1; -.
DR RefSeq; NP_001240839.2; NM_001253910.2.
DR RefSeq; XP_006505282.1; XM_006505219.2.
DR AlphaFoldDB; E0CYR6; -.
DR STRING; 10090.ENSMUSP00000123947; -.
DR jPOST; E0CYR6; -.
DR MaxQB; E0CYR6; -.
DR PaxDb; E0CYR6; -.
DR PeptideAtlas; E0CYR6; -.
DR PRIDE; E0CYR6; -.
DR ProteomicsDB; 328936; -.
DR Ensembl; ENSMUST00000160534; ENSMUSP00000123947; ENSMUSG00000089694.
DR Ensembl; ENSMUST00000179613; ENSMUSP00000136338; ENSMUSG00000089694.
DR GeneID; 100043497; -.
DR KEGG; mmu:100043497; -.
DR UCSC; uc009cqa.2; mouse.
DR CTD; 100043497; -.
DR MGI; MGI:3782661; Nat8f7.
DR VEuPathDB; HostDB:ENSMUSG00000089694; -.
DR eggNOG; KOG3139; Eukaryota.
DR GeneTree; ENSGT00950000182932; -.
DR HOGENOM; CLU_013985_10_1_1; -.
DR InParanoid; E0CYR6; -.
DR OMA; NKCHRAD; -.
DR OrthoDB; 1341682at2759; -.
DR PhylomeDB; E0CYR6; -.
DR TreeFam; TF324687; -.
DR BioGRID-ORCS; 100043497; 2 hits in 26 CRISPR screens.
DR ChiTaRS; Nat8f7; mouse.
DR PRO; PR:E0CYR6; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; E0CYR6; protein.
DR Bgee; ENSMUSG00000089694; Expressed in adult mammalian kidney and 32 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:MGI.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISO:MGI.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR GO; GO:0031965; C:nuclear membrane; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0047198; F:cysteine-S-conjugate N-acetyltransferase activity; ISO:MGI.
DR GO; GO:0010485; F:H4 histone acetyltransferase activity; IDA:MGI.
DR GO; GO:0004468; F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; ISO:MGI.
DR GO; GO:0008080; F:N-acetyltransferase activity; IBA:GO_Central.
DR GO; GO:0050435; P:amyloid-beta metabolic process; ISO:MGI.
DR GO; GO:0006749; P:glutathione metabolic process; ISO:MGI.
DR GO; GO:0016573; P:histone acetylation; IDA:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR GO; GO:0018003; P:peptidyl-lysine N6-acetylation; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR000182; GNAT_dom.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
DR PROSITE; PS51186; GNAT; 1.
PE 1: Evidence at protein level;
KW Acyltransferase; Membrane; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..227
FT /note="N-acetyltransferase family 8 member 7"
FT /id="PRO_0000444045"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 61..220
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ SEQUENCE 227 AA; 26101 MW; F07E48034F8B97B4 CRC64;
MAPYHIRKYQ DSDHRSVVDL FRRGMEEHIP ATFRHMLLLP RTLLLLLGVP LTLFLASGSW
LLVLLSILTL FLSLWFLAKY TWEKHVMNCL HTDMADITRT YMSSHSSCFW VAESRGQTVG
MVAARPVKDP LLQKKQLQLL HLSVSLQHRR EGLGKAMVRT VLQFAQMQGF SEVVLSTSML
QYAALALYQG MGFQKTGETF YTYLSRLRKS PMINLKYSLT SPWEGDL
