NTAQ1_HUMAN
ID NTAQ1_HUMAN Reviewed; 205 AA.
AC Q96HA8; B4DE68; Q9NW95;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Protein N-terminal glutamine amidohydrolase {ECO:0000305};
DE EC=3.5.1.122 {ECO:0000250|UniProtKB:Q80WB5};
DE AltName: Full=Protein NH2-terminal glutamine deamidase;
DE Short=N-terminal Gln amidase;
DE Short=Nt(Q)-amidase;
DE AltName: Full=WDYHV motif-containing protein 1;
GN Name=NTAQ1 {ECO:0000312|HGNC:HGNC:25490}; Synonyms=C8orf32, WDYHV1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Cerebellum, and Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS VAL-32;
RP SER-93; ILE-116 AND CYS-134.
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 2-205 IN COMPLEX WITH SER-THR-ALA
RP TRIPEPTIDE, AND SUBUNIT.
RX PubMed=25356641; DOI=10.1371/journal.pone.0111142;
RA Park M.S., Bitto E., Kim K.R., Bingman C.A., Miller M.D., Kim H.J.,
RA Han B.W., Phillips G.N. Jr.;
RT "Crystal structure of human protein N-terminal glutamine amidohydrolase, an
RT initial component of the N-end rule pathway.";
RL PLoS ONE 9:e111142-e111142(2014).
CC -!- FUNCTION: Mediates the side-chain deamidation of N-terminal glutamine
CC residues to glutamate, an important step in N-end rule pathway of
CC protein degradation. Conversion of the resulting N-terminal glutamine
CC to glutamate renders the protein susceptible to arginylation,
CC polyubiquitination and degradation as specified by the N-end rule. Does
CC not act on substrates with internal or C-terminal glutamine and does
CC not act on non-glutamine residues in any position. Does not deaminate
CC acetylated N-terminal glutamine. With the exception of proline, all
CC tested second-position residues on substrate peptides do not greatly
CC influence the activity. In contrast, a proline at position 2, virtually
CC abolishes deamidation of N-terminal glutamine.
CC {ECO:0000250|UniProtKB:Q80WB5}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-terminal L-glutaminyl-[protein] = N-terminal L-
CC glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:50680, Rhea:RHEA-
CC COMP:12668, Rhea:RHEA-COMP:12777, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:28938, ChEBI:CHEBI:64721, ChEBI:CHEBI:64722;
CC EC=3.5.1.122; Evidence={ECO:0000250|UniProtKB:Q80WB5};
CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:25356641}.
CC -!- INTERACTION:
CC Q96HA8; Q4LEZ3: AARD; NbExp=3; IntAct=EBI-741158, EBI-5463075;
CC Q96HA8; A0A590TQL1: ACD; NbExp=3; IntAct=EBI-741158, EBI-23197871;
CC Q96HA8; Q9NPJ3: ACOT13; NbExp=3; IntAct=EBI-741158, EBI-1045357;
CC Q96HA8; P60709: ACTB; NbExp=6; IntAct=EBI-741158, EBI-353944;
CC Q96HA8; P63261: ACTG1; NbExp=7; IntAct=EBI-741158, EBI-351292;
CC Q96HA8; P35609: ACTN2; NbExp=3; IntAct=EBI-741158, EBI-77797;
CC Q96HA8; Q03154: ACY1; NbExp=3; IntAct=EBI-741158, EBI-742064;
CC Q96HA8; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-741158, EBI-10173507;
CC Q96HA8; O95994: AGR2; NbExp=3; IntAct=EBI-741158, EBI-712648;
CC Q96HA8; Q8TD06: AGR3; NbExp=3; IntAct=EBI-741158, EBI-3925742;
CC Q96HA8; Q13155: AIMP2; NbExp=3; IntAct=EBI-741158, EBI-745226;
CC Q96HA8; Q53H80: AKIRIN2; NbExp=3; IntAct=EBI-741158, EBI-742928;
CC Q96HA8; A2BDD9: AMOT; NbExp=3; IntAct=EBI-741158, EBI-17286414;
CC Q96HA8; Q4VCS5-2: AMOT; NbExp=3; IntAct=EBI-741158, EBI-3891843;
CC Q96HA8; Q9Y2J4-4: AMOTL2; NbExp=3; IntAct=EBI-741158, EBI-10187270;
CC Q96HA8; Q01433-2: AMPD2; NbExp=3; IntAct=EBI-741158, EBI-11957578;
CC Q96HA8; X5D778: ANKRD11; NbExp=3; IntAct=EBI-741158, EBI-17183751;
CC Q96HA8; Q8N2N9-4: ANKRD36B; NbExp=3; IntAct=EBI-741158, EBI-12170453;
CC Q96HA8; P19801: AOC1; NbExp=3; IntAct=EBI-741158, EBI-12826295;
CC Q96HA8; Q96GX9: APIP; NbExp=5; IntAct=EBI-741158, EBI-359248;
CC Q96HA8; Q4LE39-3: ARID4B; NbExp=3; IntAct=EBI-741158, EBI-11957452;
CC Q96HA8; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-741158, EBI-714543;
CC Q96HA8; P04424: ASL; NbExp=7; IntAct=EBI-741158, EBI-750131;
CC Q96HA8; O75348: ATP6V1G1; NbExp=3; IntAct=EBI-741158, EBI-711802;
CC Q96HA8; Q9H503-2: BANF2; NbExp=3; IntAct=EBI-741158, EBI-11977289;
CC Q96HA8; Q7L4P6: BEND5; NbExp=3; IntAct=EBI-741158, EBI-724373;
CC Q96HA8; Q13490: BIRC2; NbExp=6; IntAct=EBI-741158, EBI-514538;
CC Q96HA8; Q96CA5: BIRC7; NbExp=3; IntAct=EBI-741158, EBI-517623;
CC Q96HA8; Q13867: BLMH; NbExp=4; IntAct=EBI-741158, EBI-718504;
CC Q96HA8; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-741158, EBI-2548012;
CC Q96HA8; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-741158, EBI-12006120;
CC Q96HA8; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-741158, EBI-10193358;
CC Q96HA8; P59826: BPIFB3; NbExp=3; IntAct=EBI-741158, EBI-1055244;
CC Q96HA8; Q9H0C5: BTBD1; NbExp=3; IntAct=EBI-741158, EBI-935503;
CC Q96HA8; Q9BX70: BTBD2; NbExp=3; IntAct=EBI-741158, EBI-710091;
CC Q96HA8; Q96KE9-2: BTBD6; NbExp=3; IntAct=EBI-741158, EBI-12012762;
CC Q96HA8; Q9BV19: C1orf50; NbExp=6; IntAct=EBI-741158, EBI-2874661;
CC Q96HA8; Q9UQM7: CAMK2A; NbExp=3; IntAct=EBI-741158, EBI-1383687;
CC Q96HA8; P20807: CAPN3; NbExp=3; IntAct=EBI-741158, EBI-5655000;
CC Q96HA8; P20807-4: CAPN3; NbExp=3; IntAct=EBI-741158, EBI-11532021;
CC Q96HA8; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-741158, EBI-11530605;
CC Q96HA8; P55212: CASP6; NbExp=3; IntAct=EBI-741158, EBI-718729;
CC Q96HA8; Q5BKX8: CAVIN4; NbExp=3; IntAct=EBI-741158, EBI-12836558;
CC Q96HA8; Q8NA61-2: CBY2; NbExp=5; IntAct=EBI-741158, EBI-11524851;
CC Q96HA8; Q68D86: CCDC102B; NbExp=4; IntAct=EBI-741158, EBI-10171570;
CC Q96HA8; Q96NT0: CCDC115; NbExp=3; IntAct=EBI-741158, EBI-2810325;
CC Q96HA8; Q4G0S7: CCDC152; NbExp=3; IntAct=EBI-741158, EBI-18398007;
CC Q96HA8; Q52MB2: CCDC184; NbExp=3; IntAct=EBI-741158, EBI-10179526;
CC Q96HA8; Q8NCU1: CCDC197; NbExp=3; IntAct=EBI-741158, EBI-750686;
CC Q96HA8; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-741158, EBI-10175300;
CC Q96HA8; Q9NPC3: CCNB1IP1; NbExp=3; IntAct=EBI-741158, EBI-745269;
CC Q96HA8; P20273-5: CD22; NbExp=3; IntAct=EBI-741158, EBI-13320645;
CC Q96HA8; P32320: CDA; NbExp=9; IntAct=EBI-741158, EBI-9250559;
CC Q96HA8; Q53HL2: CDCA8; NbExp=3; IntAct=EBI-741158, EBI-979174;
CC Q96HA8; O14519: CDK2AP1; NbExp=3; IntAct=EBI-741158, EBI-1052532;
CC Q96HA8; Q96HQ2: CDKN2AIPNL; NbExp=3; IntAct=EBI-741158, EBI-10038935;
CC Q96HA8; Q01850: CDR2; NbExp=4; IntAct=EBI-741158, EBI-1181367;
CC Q96HA8; Q6IPU0: CENPP; NbExp=3; IntAct=EBI-741158, EBI-10250303;
CC Q96HA8; Q9Y4F5-3: CEP170B; NbExp=3; IntAct=EBI-741158, EBI-12950757;
CC Q96HA8; Q53EZ4: CEP55; NbExp=5; IntAct=EBI-741158, EBI-747776;
CC Q96HA8; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-741158, EBI-739624;
CC Q96HA8; Q6P2H3-3: CEP85; NbExp=3; IntAct=EBI-741158, EBI-12368239;
CC Q96HA8; Q9UFW8: CGGBP1; NbExp=3; IntAct=EBI-741158, EBI-723153;
CC Q96HA8; Q9NX63: CHCHD3; NbExp=3; IntAct=EBI-741158, EBI-743375;
CC Q96HA8; Q9BY43-2: CHMP4A; NbExp=3; IntAct=EBI-741158, EBI-12178895;
CC Q96HA8; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-741158, EBI-11522780;
CC Q96HA8; Q9Y2V7: COG6; NbExp=5; IntAct=EBI-741158, EBI-3866319;
CC Q96HA8; P38432: COIL; NbExp=3; IntAct=EBI-741158, EBI-945751;
CC Q96HA8; P02489: CRYAA; NbExp=7; IntAct=EBI-741158, EBI-6875961;
CC Q96HA8; P67870: CSNK2B; NbExp=3; IntAct=EBI-741158, EBI-348169;
CC Q96HA8; Q5HYN5: CT45A1; NbExp=3; IntAct=EBI-741158, EBI-12051833;
CC Q96HA8; P78358: CTAG1B; NbExp=3; IntAct=EBI-741158, EBI-1188472;
CC Q96HA8; P32929: CTH; NbExp=3; IntAct=EBI-741158, EBI-749763;
CC Q96HA8; Q9NWM3: CUEDC1; NbExp=3; IntAct=EBI-741158, EBI-5838167;
CC Q96HA8; Q9NTM9: CUTC; NbExp=3; IntAct=EBI-741158, EBI-714918;
CC Q96HA8; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-741158, EBI-3867333;
CC Q96HA8; O75553: DAB1; NbExp=3; IntAct=EBI-741158, EBI-7875264;
CC Q96HA8; Q9H773: DCTPP1; NbExp=5; IntAct=EBI-741158, EBI-723569;
CC Q96HA8; Q05D60: DEUP1; NbExp=3; IntAct=EBI-741158, EBI-748597;
CC Q96HA8; P49366: DHPS; NbExp=3; IntAct=EBI-741158, EBI-741925;
CC Q96HA8; O96015: DNAL4; NbExp=3; IntAct=EBI-741158, EBI-742362;
CC Q96HA8; P63172: DYNLT1; NbExp=3; IntAct=EBI-741158, EBI-1176455;
CC Q96HA8; Q8WWZ3: EDARADD; NbExp=4; IntAct=EBI-741158, EBI-2949647;
CC Q96HA8; Q9H6Z9: EGLN3; NbExp=3; IntAct=EBI-741158, EBI-1175354;
CC Q96HA8; Q14232: EIF2B1; NbExp=7; IntAct=EBI-741158, EBI-491065;
CC Q96HA8; Q04637-9: EIF4G1; NbExp=3; IntAct=EBI-741158, EBI-12012124;
CC Q96HA8; Q9NT22: EMILIN3; NbExp=3; IntAct=EBI-741158, EBI-3197883;
CC Q96HA8; A0A0A0MR80: EP400; NbExp=3; IntAct=EBI-741158, EBI-12089140;
CC Q96HA8; I6L9I8: EPN3; NbExp=3; IntAct=EBI-741158, EBI-12866582;
CC Q96HA8; P41212: ETV6; NbExp=3; IntAct=EBI-741158, EBI-1372759;
CC Q96HA8; Q96B26: EXOSC8; NbExp=3; IntAct=EBI-741158, EBI-371922;
CC Q96HA8; Q96C01: FAM136A; NbExp=3; IntAct=EBI-741158, EBI-373319;
CC Q96HA8; Q5TYM5: FAM72A; NbExp=3; IntAct=EBI-741158, EBI-10237116;
CC Q96HA8; Q6L9T8: FAM72D; NbExp=3; IntAct=EBI-741158, EBI-18397873;
CC Q96HA8; O75344: FKBP6; NbExp=3; IntAct=EBI-741158, EBI-744771;
CC Q96HA8; Q6NZ44: FTH1; NbExp=3; IntAct=EBI-741158, EBI-10180219;
CC Q96HA8; P02792: FTL; NbExp=3; IntAct=EBI-741158, EBI-713279;
CC Q96HA8; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-741158, EBI-372506;
CC Q96HA8; O60861: GAS7; NbExp=4; IntAct=EBI-741158, EBI-2683717;
CC Q96HA8; O60861-1: GAS7; NbExp=5; IntAct=EBI-741158, EBI-11745923;
CC Q96HA8; Q5JQS6: GCSAML; NbExp=3; IntAct=EBI-741158, EBI-17857617;
CC Q96HA8; P14136: GFAP; NbExp=3; IntAct=EBI-741158, EBI-744302;
CC Q96HA8; O60547: GMDS; NbExp=6; IntAct=EBI-741158, EBI-746373;
CC Q96HA8; P63215: GNG3; NbExp=3; IntAct=EBI-741158, EBI-1046668;
CC Q96HA8; Q14749: GNMT; NbExp=5; IntAct=EBI-741158, EBI-744239;
CC Q96HA8; Q8TDQ7-2: GNPDA2; NbExp=3; IntAct=EBI-741158, EBI-12197555;
CC Q96HA8; Q08379: GOLGA2; NbExp=8; IntAct=EBI-741158, EBI-618309;
CC Q96HA8; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-741158, EBI-5916454;
CC Q96HA8; Q96SL4: GPX7; NbExp=3; IntAct=EBI-741158, EBI-749411;
CC Q96HA8; Q6IC98: GRAMD4; NbExp=3; IntAct=EBI-741158, EBI-10962409;
CC Q96HA8; O15217: GSTA4; NbExp=3; IntAct=EBI-741158, EBI-752440;
CC Q96HA8; Q9H4Y5: GSTO2; NbExp=3; IntAct=EBI-741158, EBI-10194609;
CC Q96HA8; Q6P1K8: GTF2H2C_2; NbExp=3; IntAct=EBI-741158, EBI-8469755;
CC Q96HA8; O75409: H2AP; NbExp=3; IntAct=EBI-741158, EBI-6447217;
CC Q96HA8; Q9BT25: HAUS8; NbExp=3; IntAct=EBI-741158, EBI-2558143;
CC Q96HA8; P09105: HBQ1; NbExp=3; IntAct=EBI-741158, EBI-10193656;
CC Q96HA8; P02008: HBZ; NbExp=3; IntAct=EBI-741158, EBI-719843;
CC Q96HA8; Q86XA9-3: HEATR5A; NbExp=3; IntAct=EBI-741158, EBI-17981660;
CC Q96HA8; V9HW60: HEL-S-182mP; NbExp=3; IntAct=EBI-741158, EBI-10180762;
CC Q96HA8; V9HW80: HEL-S-70; NbExp=3; IntAct=EBI-741158, EBI-10175326;
CC Q96HA8; Q93099: HGD; NbExp=3; IntAct=EBI-741158, EBI-3907760;
CC Q96HA8; A8MV81: HIGD1C; NbExp=3; IntAct=EBI-741158, EBI-12809676;
CC Q96HA8; Q9NP66: HMG20A; NbExp=5; IntAct=EBI-741158, EBI-740641;
CC Q96HA8; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-741158, EBI-748420;
CC Q96HA8; P17509: HOXB6; NbExp=3; IntAct=EBI-741158, EBI-741308;
CC Q96HA8; P00492: HPRT1; NbExp=10; IntAct=EBI-741158, EBI-748210;
CC Q96HA8; Q9BPX1: HSD17B14; NbExp=13; IntAct=EBI-741158, EBI-742664;
CC Q96HA8; O75031: HSF2BP; NbExp=3; IntAct=EBI-741158, EBI-7116203;
CC Q96HA8; P61604: HSPE1; NbExp=3; IntAct=EBI-741158, EBI-711483;
CC Q96HA8; O60921: HUS1; NbExp=3; IntAct=EBI-741158, EBI-1056174;
CC Q96HA8; Q14005-2: IL16; NbExp=3; IntAct=EBI-741158, EBI-17178971;
CC Q96HA8; Q6EBC2: IL31; NbExp=3; IntAct=EBI-741158, EBI-18286692;
CC Q96HA8; Q0VD86: INCA1; NbExp=5; IntAct=EBI-741158, EBI-6509505;
CC Q96HA8; Q86U28: ISCA2; NbExp=3; IntAct=EBI-741158, EBI-10258659;
CC Q96HA8; Q13352: ITGB3BP; NbExp=3; IntAct=EBI-741158, EBI-712105;
CC Q96HA8; P14923: JUP; NbExp=3; IntAct=EBI-741158, EBI-702484;
CC Q96HA8; Q9H079: KATNBL1; NbExp=3; IntAct=EBI-741158, EBI-715394;
CC Q96HA8; O95259: KCNH1; NbExp=3; IntAct=EBI-741158, EBI-2909270;
CC Q96HA8; Q719H9: KCTD1; NbExp=4; IntAct=EBI-741158, EBI-9027502;
CC Q96HA8; Q9H3F6: KCTD10; NbExp=3; IntAct=EBI-741158, EBI-2505886;
CC Q96HA8; Q8WZ19: KCTD13; NbExp=3; IntAct=EBI-741158, EBI-742916;
CC Q96HA8; Q96SI1-2: KCTD15; NbExp=3; IntAct=EBI-741158, EBI-12382297;
CC Q96HA8; Q4G0X4: KCTD21; NbExp=3; IntAct=EBI-741158, EBI-11976683;
CC Q96HA8; Q8WVF5: KCTD4; NbExp=3; IntAct=EBI-741158, EBI-741463;
CC Q96HA8; Q8NC69: KCTD6; NbExp=3; IntAct=EBI-741158, EBI-2511344;
CC Q96HA8; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-741158, EBI-11954971;
CC Q96HA8; Q7L273: KCTD9; NbExp=3; IntAct=EBI-741158, EBI-4397613;
CC Q96HA8; Q14145: KEAP1; NbExp=3; IntAct=EBI-741158, EBI-751001;
CC Q96HA8; O75037-4: KIF21B; NbExp=3; IntAct=EBI-741158, EBI-12897871;
CC Q96HA8; Q53G59: KLHL12; NbExp=8; IntAct=EBI-741158, EBI-740929;
CC Q96HA8; O95198: KLHL2; NbExp=3; IntAct=EBI-741158, EBI-746999;
CC Q96HA8; Q9BS75: KLHL20; NbExp=5; IntAct=EBI-741158, EBI-10693436;
CC Q96HA8; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-741158, EBI-3044087;
CC Q96HA8; Q15323: KRT31; NbExp=3; IntAct=EBI-741158, EBI-948001;
CC Q96HA8; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-741158, EBI-10172150;
CC Q96HA8; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-741158, EBI-10172290;
CC Q96HA8; Q3LHN2: KRTAP19-2; NbExp=5; IntAct=EBI-741158, EBI-12196745;
CC Q96HA8; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-741158, EBI-12805508;
CC Q96HA8; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-741158, EBI-9996449;
CC Q96HA8; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-741158, EBI-3957694;
CC Q96HA8; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-741158, EBI-10172511;
CC Q96HA8; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-741158, EBI-3958099;
CC Q96HA8; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-741158, EBI-12111050;
CC Q96HA8; Q9BYQ4: KRTAP9-2; NbExp=6; IntAct=EBI-741158, EBI-1044640;
CC Q96HA8; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-741158, EBI-10185730;
CC Q96HA8; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-741158, EBI-11958364;
CC Q96HA8; Q96JM7-2: L3MBTL3; NbExp=3; IntAct=EBI-741158, EBI-11985629;
CC Q96HA8; Q5T751: LCE1C; NbExp=3; IntAct=EBI-741158, EBI-12224199;
CC Q96HA8; Q5T752: LCE1D; NbExp=3; IntAct=EBI-741158, EBI-11741311;
CC Q96HA8; Q5T753: LCE1E; NbExp=3; IntAct=EBI-741158, EBI-11955335;
CC Q96HA8; Q5T754: LCE1F; NbExp=3; IntAct=EBI-741158, EBI-11958008;
CC Q96HA8; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-741158, EBI-11973993;
CC Q96HA8; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-741158, EBI-11955689;
CC Q96HA8; O43679: LDB2; NbExp=3; IntAct=EBI-741158, EBI-2865580;
CC Q96HA8; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-741158, EBI-726510;
CC Q96HA8; P05162: LGALS2; NbExp=3; IntAct=EBI-741158, EBI-7181544;
CC Q96HA8; Q3B8N2: LGALS9B; NbExp=3; IntAct=EBI-741158, EBI-10240775;
CC Q96HA8; Q9HAP6: LIN7B; NbExp=3; IntAct=EBI-741158, EBI-821335;
CC Q96HA8; P25800: LMO1; NbExp=3; IntAct=EBI-741158, EBI-8639312;
CC Q96HA8; P25791-3: LMO2; NbExp=3; IntAct=EBI-741158, EBI-11959475;
CC Q96HA8; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-741158, EBI-11742507;
CC Q96HA8; Q17RB8: LONRF1; NbExp=4; IntAct=EBI-741158, EBI-2341787;
CC Q96HA8; Q5T3J3: LRIF1; NbExp=3; IntAct=EBI-741158, EBI-473196;
CC Q96HA8; Q5JTD7: LRRC73; NbExp=3; IntAct=EBI-741158, EBI-12003882;
CC Q96HA8; Q3MHD2: LSM12; NbExp=3; IntAct=EBI-741158, EBI-725133;
CC Q96HA8; Q9BX40-2: LSM14B; NbExp=3; IntAct=EBI-741158, EBI-19133880;
CC Q96HA8; Q9NQ48: LZTFL1; NbExp=4; IntAct=EBI-741158, EBI-2824799;
CC Q96HA8; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-741158, EBI-1216080;
CC Q96HA8; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-741158, EBI-741037;
CC Q96HA8; Q8N8X9: MAB21L3; NbExp=3; IntAct=EBI-741158, EBI-10268010;
CC Q96HA8; Q9Y6D9: MAD1L1; NbExp=3; IntAct=EBI-741158, EBI-742610;
CC Q96HA8; P43364: MAGEA11; NbExp=3; IntAct=EBI-741158, EBI-739552;
CC Q96HA8; P43364-2: MAGEA11; NbExp=3; IntAct=EBI-741158, EBI-10178634;
CC Q96HA8; P43365: MAGEA12; NbExp=3; IntAct=EBI-741158, EBI-749530;
CC Q96HA8; P43356: MAGEA2B; NbExp=5; IntAct=EBI-741158, EBI-5650739;
CC Q96HA8; Q96EH3: MALSU1; NbExp=3; IntAct=EBI-741158, EBI-2339737;
CC Q96HA8; Q8NA82: MARCHF10; NbExp=3; IntAct=EBI-741158, EBI-2341554;
CC Q96HA8; O95460-2: MATN4; NbExp=3; IntAct=EBI-741158, EBI-12072296;
CC Q96HA8; Q15528-2: MED22; NbExp=3; IntAct=EBI-741158, EBI-12954271;
CC Q96HA8; P14174: MIF; NbExp=4; IntAct=EBI-741158, EBI-372712;
CC Q96HA8; A9UHW6-2: MIF4GD; NbExp=3; IntAct=EBI-741158, EBI-9118295;
CC Q96HA8; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-741158, EBI-2548751;
CC Q96HA8; Q9NYP9: MIS18A; NbExp=3; IntAct=EBI-741158, EBI-1104552;
CC Q96HA8; Q8WV92: MITD1; NbExp=3; IntAct=EBI-741158, EBI-2691489;
CC Q96HA8; Q70IA6: MOB2; NbExp=3; IntAct=EBI-741158, EBI-2558739;
CC Q96HA8; Q6PF18: MORN3; NbExp=3; IntAct=EBI-741158, EBI-9675802;
CC Q96HA8; Q8TAP9: MPLKIP; NbExp=3; IntAct=EBI-741158, EBI-11603426;
CC Q96HA8; Q96HT8: MRFAP1L1; NbExp=3; IntAct=EBI-741158, EBI-748896;
CC Q96HA8; P52815: MRPL12; NbExp=3; IntAct=EBI-741158, EBI-358272;
CC Q96HA8; Q9H903-3: MTHFD2L; NbExp=3; IntAct=EBI-741158, EBI-14202147;
CC Q96HA8; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-741158, EBI-742948;
CC Q96HA8; Q5JR59-3: MTUS2; NbExp=5; IntAct=EBI-741158, EBI-11522433;
CC Q96HA8; Q14764: MVP; NbExp=3; IntAct=EBI-741158, EBI-2816254;
CC Q96HA8; Q9BRK3: MXRA8; NbExp=3; IntAct=EBI-741158, EBI-11721798;
CC Q96HA8; Q99836: MYD88; NbExp=3; IntAct=EBI-741158, EBI-447677;
CC Q96HA8; O15049: N4BP3; NbExp=3; IntAct=EBI-741158, EBI-2512055;
CC Q96HA8; Q15742: NAB2; NbExp=3; IntAct=EBI-741158, EBI-8641936;
CC Q96HA8; Q6IA69: NADSYN1; NbExp=3; IntAct=EBI-741158, EBI-748610;
CC Q96HA8; Q9UJ70-2: NAGK; NbExp=5; IntAct=EBI-741158, EBI-11526455;
CC Q96HA8; O14561: NDUFAB1; NbExp=3; IntAct=EBI-741158, EBI-1246261;
CC Q96HA8; Q7Z6G3-2: NECAB2; NbExp=8; IntAct=EBI-741158, EBI-10172876;
CC Q96HA8; P15531: NME1; NbExp=8; IntAct=EBI-741158, EBI-741141;
CC Q96HA8; Q9BXD5: NPL; NbExp=3; IntAct=EBI-741158, EBI-10287915;
CC Q96HA8; Q13285: NR5A1; NbExp=3; IntAct=EBI-741158, EBI-874629;
CC Q96HA8; Q9BXI3: NT5C1A; NbExp=6; IntAct=EBI-741158, EBI-10441581;
CC Q96HA8; O95848: NUDT14; NbExp=4; IntAct=EBI-741158, EBI-536866;
CC Q96HA8; Q9BRJ7: NUDT16L1; NbExp=3; IntAct=EBI-741158, EBI-2949792;
CC Q96HA8; O43809: NUDT21; NbExp=5; IntAct=EBI-741158, EBI-355720;
CC Q96HA8; A6NGQ2: OOEP; NbExp=3; IntAct=EBI-741158, EBI-18583589;
CC Q96HA8; Q9P286: PAK5; NbExp=3; IntAct=EBI-741158, EBI-741896;
CC Q96HA8; P61457: PCBD1; NbExp=4; IntAct=EBI-741158, EBI-740475;
CC Q96HA8; Q99471: PFDN5; NbExp=3; IntAct=EBI-741158, EBI-357275;
CC Q96HA8; Q9NXJ5-2: PGPEP1; NbExp=3; IntAct=EBI-741158, EBI-12813581;
CC Q96HA8; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-741158, EBI-10232538;
CC Q96HA8; O15496: PLA2G10; NbExp=4; IntAct=EBI-741158, EBI-726466;
CC Q96HA8; P51178: PLCD1; NbExp=3; IntAct=EBI-741158, EBI-4405387;
CC Q96HA8; Q96CS7: PLEKHB2; NbExp=5; IntAct=EBI-741158, EBI-373552;
CC Q96HA8; Q9NW61: PLEKHJ1; NbExp=3; IntAct=EBI-741158, EBI-1057560;
CC Q96HA8; Q8ND90: PNMA1; NbExp=6; IntAct=EBI-741158, EBI-302345;
CC Q96HA8; Q9UL42: PNMA2; NbExp=3; IntAct=EBI-741158, EBI-302355;
CC Q96HA8; Q96PV4: PNMA5; NbExp=7; IntAct=EBI-741158, EBI-10171633;
CC Q96HA8; P52435: POLR2J; NbExp=3; IntAct=EBI-741158, EBI-394753;
CC Q96HA8; P01189: POMC; NbExp=3; IntAct=EBI-741158, EBI-12219503;
CC Q96HA8; Q96CD2: PPCDC; NbExp=6; IntAct=EBI-741158, EBI-724333;
CC Q96HA8; Q8N3J5: PPM1K; NbExp=3; IntAct=EBI-741158, EBI-3923368;
CC Q96HA8; Q86WC6: PPP1R27; NbExp=3; IntAct=EBI-741158, EBI-5235602;
CC Q96HA8; P31321: PRKAR1B; NbExp=3; IntAct=EBI-741158, EBI-2805516;
CC Q96HA8; Q99873: PRMT1; NbExp=3; IntAct=EBI-741158, EBI-78738;
CC Q96HA8; O14744: PRMT5; NbExp=3; IntAct=EBI-741158, EBI-351098;
CC Q96HA8; P11908: PRPS2; NbExp=4; IntAct=EBI-741158, EBI-4290895;
CC Q96HA8; P86480: PRR20D; NbExp=3; IntAct=EBI-741158, EBI-12754095;
CC Q96HA8; Q6ZRT6: PRR23B; NbExp=3; IntAct=EBI-741158, EBI-12845180;
CC Q96HA8; Q9NRG1: PRTFDC1; NbExp=3; IntAct=EBI-741158, EBI-739759;
CC Q96HA8; Q1KLZ0: PS1TP5BP1; NbExp=3; IntAct=EBI-741158, EBI-9978131;
CC Q96HA8; P28074: PSMB5; NbExp=3; IntAct=EBI-741158, EBI-357828;
CC Q96HA8; P61289: PSME3; NbExp=5; IntAct=EBI-741158, EBI-355546;
CC Q96HA8; Q03393: PTS; NbExp=3; IntAct=EBI-741158, EBI-712344;
CC Q96HA8; Q53H96: PYCR3; NbExp=3; IntAct=EBI-741158, EBI-2959680;
CC Q96HA8; P11217: PYGM; NbExp=4; IntAct=EBI-741158, EBI-357469;
CC Q96HA8; Q8N4Z0-1: RAB42; NbExp=3; IntAct=EBI-741158, EBI-17857145;
CC Q96HA8; Q9UI14: RABAC1; NbExp=9; IntAct=EBI-741158, EBI-712367;
CC Q96HA8; Q92698: RAD54L; NbExp=4; IntAct=EBI-741158, EBI-5333483;
CC Q96HA8; Q86YV0: RASAL3; NbExp=3; IntAct=EBI-741158, EBI-3437896;
CC Q96HA8; Q5T481: RBM20; NbExp=3; IntAct=EBI-741158, EBI-11352885;
CC Q96HA8; Q8IUH3-3: RBM45; NbExp=3; IntAct=EBI-741158, EBI-10964453;
CC Q96HA8; Q5RL73: RBM48; NbExp=3; IntAct=EBI-741158, EBI-473821;
CC Q96HA8; Q93062: RBPMS; NbExp=3; IntAct=EBI-741158, EBI-740322;
CC Q96HA8; Q7Z3Z2: RD3; NbExp=3; IntAct=EBI-741158, EBI-10257497;
CC Q96HA8; Q96HR9-2: REEP6; NbExp=3; IntAct=EBI-741158, EBI-14065960;
CC Q96HA8; P17081: RHOQ; NbExp=3; IntAct=EBI-741158, EBI-689202;
CC Q96HA8; Q5EBL4-3: RILPL1; NbExp=3; IntAct=EBI-741158, EBI-12072024;
CC Q96HA8; Q8WVD3: RNF138; NbExp=3; IntAct=EBI-741158, EBI-749039;
CC Q96HA8; P78317: RNF4; NbExp=3; IntAct=EBI-741158, EBI-2340927;
CC Q96HA8; Q9HAT0: ROPN1; NbExp=5; IntAct=EBI-741158, EBI-1378139;
CC Q96HA8; P49247: RPIA; NbExp=8; IntAct=EBI-741158, EBI-744831;
CC Q96HA8; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-741158, EBI-6257312;
CC Q96HA8; P31949: S100A11; NbExp=3; IntAct=EBI-741158, EBI-701862;
CC Q96HA8; O00422: SAP18; NbExp=3; IntAct=EBI-741158, EBI-1044156;
CC Q96HA8; Q9NP81: SARS2; NbExp=3; IntAct=EBI-741158, EBI-1049768;
CC Q96HA8; P21673: SAT1; NbExp=3; IntAct=EBI-741158, EBI-711613;
CC Q96HA8; Q6ZMJ2-2: SCARA5; NbExp=3; IntAct=EBI-741158, EBI-12823227;
CC Q96HA8; P59797: SELENOV; NbExp=3; IntAct=EBI-741158, EBI-10216195;
CC Q96HA8; Q6ZU15: SEPTIN14; NbExp=3; IntAct=EBI-741158, EBI-2009297;
CC Q96HA8; Q9UH03: SEPTIN3; NbExp=3; IntAct=EBI-741158, EBI-727037;
CC Q96HA8; P31947: SFN; NbExp=4; IntAct=EBI-741158, EBI-476295;
CC Q96HA8; Q9NR46: SH3GLB2; NbExp=3; IntAct=EBI-741158, EBI-749607;
CC Q96HA8; Q8IUQ4: SIAH1; NbExp=3; IntAct=EBI-741158, EBI-747107;
CC Q96HA8; Q9BRV8: SIKE1; NbExp=3; IntAct=EBI-741158, EBI-1773646;
CC Q96HA8; O15304-2: SIVA1; NbExp=3; IntAct=EBI-741158, EBI-12372219;
CC Q96HA8; Q8ND83: SLAIN1; NbExp=3; IntAct=EBI-741158, EBI-10269374;
CC Q96HA8; Q16348: SLC15A2; NbExp=3; IntAct=EBI-741158, EBI-12806032;
CC Q96HA8; P03973: SLPI; NbExp=3; IntAct=EBI-741158, EBI-355293;
CC Q96HA8; Q8IYB5-2: SMAP1; NbExp=3; IntAct=EBI-741158, EBI-12061577;
CC Q96HA8; O95721: SNAP29; NbExp=3; IntAct=EBI-741158, EBI-490676;
CC Q96HA8; P62318: SNRPD3; NbExp=3; IntAct=EBI-741158, EBI-372789;
CC Q96HA8; Q9NS25: SPANXB1; NbExp=3; IntAct=EBI-741158, EBI-17197485;
CC Q96HA8; Q96LK8: SPATA32; NbExp=3; IntAct=EBI-741158, EBI-12849978;
CC Q96HA8; A6NLX3: SPDYE4; NbExp=3; IntAct=EBI-741158, EBI-12047907;
CC Q96HA8; Q9BUA3: SPINDOC; NbExp=3; IntAct=EBI-741158, EBI-1773488;
CC Q96HA8; Q5W111-2: SPRYD7; NbExp=3; IntAct=EBI-741158, EBI-12408727;
CC Q96HA8; O43805: SSNA1; NbExp=3; IntAct=EBI-741158, EBI-2515299;
CC Q96HA8; Q8IWL8: STH; NbExp=3; IntAct=EBI-741158, EBI-12843506;
CC Q96HA8; Q93045: STMN2; NbExp=3; IntAct=EBI-741158, EBI-714194;
CC Q96HA8; Q9H668: STN1; NbExp=3; IntAct=EBI-741158, EBI-746930;
CC Q96HA8; O75558: STX11; NbExp=3; IntAct=EBI-741158, EBI-714135;
CC Q96HA8; Q96PV0: SYNGAP1; NbExp=3; IntAct=EBI-741158, EBI-2682386;
CC Q96HA8; Q86VP1: TAX1BP1; NbExp=3; IntAct=EBI-741158, EBI-529518;
CC Q96HA8; Q96SF7: TBX15; NbExp=3; IntAct=EBI-741158, EBI-10191361;
CC Q96HA8; P56279: TCL1A; NbExp=5; IntAct=EBI-741158, EBI-749995;
CC Q96HA8; Q8TDR4: TCP10L; NbExp=3; IntAct=EBI-741158, EBI-3923210;
CC Q96HA8; Q969V4: TEKT1; NbExp=3; IntAct=EBI-741158, EBI-10180409;
CC Q96HA8; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-741158, EBI-11139477;
CC Q96HA8; Q9NVV9: THAP1; NbExp=8; IntAct=EBI-741158, EBI-741515;
CC Q96HA8; Q8TBB0: THAP6; NbExp=3; IntAct=EBI-741158, EBI-3925505;
CC Q96HA8; Q9BT49: THAP7; NbExp=3; IntAct=EBI-741158, EBI-741350;
CC Q96HA8; Q9NWX6: THG1L; NbExp=3; IntAct=EBI-741158, EBI-746510;
CC Q96HA8; Q86XR7: TICAM2; NbExp=3; IntAct=EBI-741158, EBI-525927;
CC Q96HA8; Q96CG3: TIFA; NbExp=3; IntAct=EBI-741158, EBI-740711;
CC Q96HA8; Q08117-2: TLE5; NbExp=5; IntAct=EBI-741158, EBI-11741437;
CC Q96HA8; Q8WW34: TMEM239; NbExp=3; IntAct=EBI-741158, EBI-9675724;
CC Q96HA8; Q13829: TNFAIP1; NbExp=3; IntAct=EBI-741158, EBI-2505861;
CC Q96HA8; Q96KP6: TNIP3; NbExp=3; IntAct=EBI-741158, EBI-2509913;
CC Q96HA8; A1L306: TNR; NbExp=3; IntAct=EBI-741158, EBI-10182881;
CC Q96HA8; Q9H0E2: TOLLIP; NbExp=4; IntAct=EBI-741158, EBI-74615;
CC Q96HA8; Q13114: TRAF3; NbExp=3; IntAct=EBI-741158, EBI-357631;
CC Q96HA8; O00463: TRAF5; NbExp=3; IntAct=EBI-741158, EBI-523498;
CC Q96HA8; P36406: TRIM23; NbExp=3; IntAct=EBI-741158, EBI-740098;
CC Q96HA8; P14373: TRIM27; NbExp=6; IntAct=EBI-741158, EBI-719493;
CC Q96HA8; Q13049: TRIM32; NbExp=3; IntAct=EBI-741158, EBI-742790;
CC Q96HA8; Q9C035-3: TRIM5; NbExp=3; IntAct=EBI-741158, EBI-12840050;
CC Q96HA8; Q9BYV2: TRIM54; NbExp=6; IntAct=EBI-741158, EBI-2130429;
CC Q96HA8; Q86WT6-2: TRIM69; NbExp=3; IntAct=EBI-741158, EBI-11525489;
CC Q96HA8; Q86UV6-2: TRIM74; NbExp=3; IntAct=EBI-741158, EBI-10259086;
CC Q96HA8; Q9C026: TRIM9; NbExp=3; IntAct=EBI-741158, EBI-720828;
CC Q96HA8; Q15645: TRIP13; NbExp=3; IntAct=EBI-741158, EBI-358993;
CC Q96HA8; Q15714: TSC22D1; NbExp=4; IntAct=EBI-741158, EBI-712609;
CC Q96HA8; Q15714-2: TSC22D1; NbExp=3; IntAct=EBI-741158, EBI-12034704;
CC Q96HA8; Q15631: TSN; NbExp=3; IntAct=EBI-741158, EBI-1044160;
CC Q96HA8; Q99598: TSNAX; NbExp=3; IntAct=EBI-741158, EBI-742638;
CC Q96HA8; Q9Y3C8: UFC1; NbExp=3; IntAct=EBI-741158, EBI-1045733;
CC Q96HA8; Q9H9P5-5: UNKL; NbExp=3; IntAct=EBI-741158, EBI-12817837;
CC Q96HA8; Q08AM6: VAC14; NbExp=5; IntAct=EBI-741158, EBI-2107455;
CC Q96HA8; P55072: VCP; NbExp=3; IntAct=EBI-741158, EBI-355164;
CC Q96HA8; P11473-2: VDR; NbExp=3; IntAct=EBI-741158, EBI-12874016;
CC Q96HA8; A5D8V6: VPS37C; NbExp=6; IntAct=EBI-741158, EBI-2559305;
CC Q96HA8; Q8TAG6: VXN; NbExp=3; IntAct=EBI-741158, EBI-12071548;
CC Q96HA8; P98170: XIAP; NbExp=4; IntAct=EBI-741158, EBI-517127;
CC Q96HA8; O96006: ZBED1; NbExp=3; IntAct=EBI-741158, EBI-740037;
CC Q96HA8; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-741158, EBI-742740;
CC Q96HA8; Q8NAP8: ZBTB8B; NbExp=3; IntAct=EBI-741158, EBI-17494306;
CC Q96HA8; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-741158, EBI-14104088;
CC Q96HA8; Q9NP64: ZCCHC17; NbExp=3; IntAct=EBI-741158, EBI-746345;
CC Q96HA8; P49910: ZNF165; NbExp=3; IntAct=EBI-741158, EBI-741694;
CC Q96HA8; Q9BYN7: ZNF341; NbExp=3; IntAct=EBI-741158, EBI-9089622;
CC Q96HA8; Q9C0F3: ZNF436; NbExp=3; IntAct=EBI-741158, EBI-8489702;
CC Q96HA8; Q8NB15: ZNF511; NbExp=3; IntAct=EBI-741158, EBI-10269136;
CC Q96HA8; Q5T7W0: ZNF618; NbExp=3; IntAct=EBI-741158, EBI-6255994;
CC Q96HA8; Q9H4T2: ZSCAN16; NbExp=3; IntAct=EBI-741158, EBI-723596;
CC Q96HA8; P0DTC9: N; Xeno; NbExp=3; IntAct=EBI-741158, EBI-25475856;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q80WB5}. Nucleus {ECO:0000250|UniProtKB:Q80WB5}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96HA8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96HA8-2; Sequence=VSP_055268;
CC -!- SIMILARITY: Belongs to the NTAQ1 family. {ECO:0000305}.
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DR EMBL; AK001066; BAA91488.1; -; mRNA.
DR EMBL; AK293492; BAG56979.1; -; mRNA.
DR EMBL; AC021305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471060; EAW92038.1; -; Genomic_DNA.
DR EMBL; BC008781; AAH08781.1; -; mRNA.
DR CCDS; CCDS6344.1; -. [Q96HA8-1]
DR CCDS; CCDS64965.1; -. [Q96HA8-2]
DR RefSeq; NP_001269953.1; NM_001283024.1. [Q96HA8-2]
DR RefSeq; NP_060494.1; NM_018024.2. [Q96HA8-1]
DR PDB; 3C9Q; X-ray; 1.50 A; A=2-205.
DR PDB; 4W79; X-ray; 1.50 A; A=2-202.
DR PDB; 6KGJ; X-ray; 1.80 A; A/B=2-202.
DR PDBsum; 3C9Q; -.
DR PDBsum; 4W79; -.
DR PDBsum; 6KGJ; -.
DR AlphaFoldDB; Q96HA8; -.
DR SMR; Q96HA8; -.
DR BioGRID; 120405; 434.
DR IntAct; Q96HA8; 424.
DR MINT; Q96HA8; -.
DR STRING; 9606.ENSP00000287387; -.
DR MoonDB; Q96HA8; Predicted.
DR iPTMnet; Q96HA8; -.
DR PhosphoSitePlus; Q96HA8; -.
DR BioMuta; WDYHV1; -.
DR DMDM; 152112225; -.
DR EPD; Q96HA8; -.
DR jPOST; Q96HA8; -.
DR MassIVE; Q96HA8; -.
DR MaxQB; Q96HA8; -.
DR PaxDb; Q96HA8; -.
DR PeptideAtlas; Q96HA8; -.
DR PRIDE; Q96HA8; -.
DR ProteomicsDB; 3924; -.
DR ProteomicsDB; 76725; -. [Q96HA8-1]
DR Antibodypedia; 13855; 68 antibodies from 18 providers.
DR DNASU; 55093; -.
DR Ensembl; ENST00000287387.7; ENSP00000287387.2; ENSG00000156795.8. [Q96HA8-1]
DR Ensembl; ENST00000523984.5; ENSP00000430427.1; ENSG00000156795.8. [Q96HA8-2]
DR Ensembl; ENST00000524254.5; ENSP00000497832.1; ENSG00000156795.8. [Q96HA8-2]
DR GeneID; 55093; -.
DR KEGG; hsa:55093; -.
DR MANE-Select; ENST00000287387.7; ENSP00000287387.2; NM_018024.3; NP_060494.1.
DR UCSC; uc003yqn.3; human. [Q96HA8-1]
DR CTD; 55093; -.
DR GeneCards; NTAQ1; -.
DR HGNC; HGNC:25490; NTAQ1.
DR HPA; ENSG00000156795; Low tissue specificity.
DR neXtProt; NX_Q96HA8; -.
DR OpenTargets; ENSG00000156795; -.
DR VEuPathDB; HostDB:ENSG00000156795; -.
DR eggNOG; KOG3261; Eukaryota.
DR GeneTree; ENSGT00390000014398; -.
DR HOGENOM; CLU_091083_1_0_1; -.
DR InParanoid; Q96HA8; -.
DR OMA; GWGTVYS; -.
DR OrthoDB; 1337506at2759; -.
DR PhylomeDB; Q96HA8; -.
DR TreeFam; TF105807; -.
DR BioCyc; MetaCyc:ENSG00000156795-MON; -.
DR BRENDA; 3.5.1.122; 2681.
DR PathwayCommons; Q96HA8; -.
DR SignaLink; Q96HA8; -.
DR BioGRID-ORCS; 55093; 13 hits in 1082 CRISPR screens.
DR ChiTaRS; WDYHV1; human.
DR EvolutionaryTrace; Q96HA8; -.
DR GeneWiki; C8orf32; -.
DR GenomeRNAi; 55093; -.
DR Pharos; Q96HA8; Tbio.
DR PRO; PR:Q96HA8; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q96HA8; protein.
DR Bgee; ENSG00000156795; Expressed in cortical plate and 188 other tissues.
DR ExpressionAtlas; Q96HA8; baseline and differential.
DR Genevisible; Q96HA8; HS.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0008418; F:protein-N-terminal asparagine amidohydrolase activity; IEA:InterPro.
DR GO; GO:0070773; F:protein-N-terminal glutamine amidohydrolase activity; ISS:UniProtKB.
DR GO; GO:0036211; P:protein modification process; ISS:UniProtKB.
DR Gene3D; 3.10.620.10; -; 1.
DR InterPro; IPR037132; N_Gln_amidohydro_ab_roll_sf.
DR InterPro; IPR039733; NTAQ1.
DR InterPro; IPR023128; Prot_N_Gln_amidohydro_ab_roll.
DR PANTHER; PTHR13035; PTHR13035; 1.
DR Pfam; PF09764; Nt_Gln_amidase; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cytoplasm; Hydrolase; Nucleus;
KW Reference proteome.
FT CHAIN 1..205
FT /note="Protein N-terminal glutamine amidohydrolase"
FT /id="PRO_0000279409"
FT ACT_SITE 28
FT /evidence="ECO:0000250"
FT ACT_SITE 81
FT /evidence="ECO:0000250"
FT ACT_SITE 97
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..60
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055268"
FT VARIANT 32
FT /note="I -> V (in dbSNP:rs6999234)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030882"
FT VARIANT 93
FT /note="N -> S (in dbSNP:rs7014678)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030883"
FT VARIANT 116
FT /note="F -> I (in dbSNP:rs6470147)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030884"
FT VARIANT 134
FT /note="R -> C (in dbSNP:rs3824250)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030885"
FT HELIX 6..8
FT /evidence="ECO:0007829|PDB:6KGJ"
FT HELIX 18..20
FT /evidence="ECO:0007829|PDB:3C9Q"
FT HELIX 28..41
FT /evidence="ECO:0007829|PDB:3C9Q"
FT STRAND 42..45
FT /evidence="ECO:0007829|PDB:3C9Q"
FT HELIX 47..49
FT /evidence="ECO:0007829|PDB:3C9Q"
FT STRAND 50..56
FT /evidence="ECO:0007829|PDB:3C9Q"
FT STRAND 62..67
FT /evidence="ECO:0007829|PDB:3C9Q"
FT STRAND 70..74
FT /evidence="ECO:0007829|PDB:6KGJ"
FT STRAND 76..79
FT /evidence="ECO:0007829|PDB:3C9Q"
FT STRAND 81..88
FT /evidence="ECO:0007829|PDB:3C9Q"
FT TURN 89..91
FT /evidence="ECO:0007829|PDB:3C9Q"
FT STRAND 92..96
FT /evidence="ECO:0007829|PDB:3C9Q"
FT STRAND 100..102
FT /evidence="ECO:0007829|PDB:3C9Q"
FT STRAND 104..107
FT /evidence="ECO:0007829|PDB:3C9Q"
FT HELIX 108..114
FT /evidence="ECO:0007829|PDB:3C9Q"
FT HELIX 124..126
FT /evidence="ECO:0007829|PDB:3C9Q"
FT STRAND 129..134
FT /evidence="ECO:0007829|PDB:3C9Q"
FT HELIX 135..141
FT /evidence="ECO:0007829|PDB:3C9Q"
FT HELIX 147..149
FT /evidence="ECO:0007829|PDB:3C9Q"
FT STRAND 152..154
FT /evidence="ECO:0007829|PDB:3C9Q"
FT STRAND 156..158
FT /evidence="ECO:0007829|PDB:3C9Q"
FT HELIX 176..179
FT /evidence="ECO:0007829|PDB:3C9Q"
FT STRAND 185..192
FT /evidence="ECO:0007829|PDB:3C9Q"
FT HELIX 193..200
FT /evidence="ECO:0007829|PDB:3C9Q"
SQ SEQUENCE 205 AA; 23680 MW; F858AB0C73928CA9 CRC64;
MEGNGPAAVH YQPASPPRDA CVYSSCYCEE NIWKLCEYIK NHDQYPLEEC YAVFISNERK
MIPIWKQQAR PGDGPVIWDY HVVLLHVSSG GQNFIYDLDT VLPFPCLFDT YVEDAFKSDD
DIHPQFRRKF RVIRADSYLK NFASDRSHMK DSSGNWREPP PPYPCIETGD SKMNLNDFIS
MDPKVGWGAV YTLSEFTHRF GSKNC
