NTC1_CAEEL
ID NTC1_CAEEL Reviewed; 103 AA.
AC Q4R128;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Nematocin {ECO:0000303|PubMed:23112335, ECO:0000303|PubMed:23112336};
DE Flags: Precursor;
GN Name=ntc-1 {ECO:0000303|PubMed:23112335, ECO:0000303|PubMed:23112336};
GN ORFNames=F39C12.4 {ECO:0000312|WormBase:F39C12.4};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AFJ42491.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DISRUPTION
RP PHENOTYPE, AND MUTAGENESIS OF 28-ARG--TYR-30.
RX PubMed=23112336; DOI=10.1126/science.1226860;
RA Beets I., Janssen T., Meelkop E., Temmerman L., Suetens N., Rademakers S.,
RA Jansen G., Schoofs L.;
RT "Vasopressin/oxytocin-related signaling regulates gustatory associative
RT learning in C. elegans.";
RL Science 338:543-545(2012).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP PROTEIN SEQUENCE OF 20-30, FUNCTION, TISSUE SPECIFICITY, DISRUPTION
RP PHENOTYPE, MASS SPECTROMETRY, AMIDATION AT TYR-30, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=23112335; DOI=10.1126/science.1226201;
RA Garrison J.L., Macosko E.Z., Bernstein S., Pokala N., Albrecht D.R.,
RA Bargmann C.I.;
RT "Oxytocin/vasopressin-related peptides have an ancient role in reproductive
RT behavior.";
RL Science 338:540-543(2012).
CC -!- FUNCTION: Ligand for the G-protein coupled receptor ntr-1
CC (PubMed:23112336, PubMed:23112335). Plays a role in gustatory
CC associative learning (PubMed:23112336). Also plays a role in male
CC mating behavior (PubMed:23112335). {ECO:0000269|PubMed:23112335,
CC ECO:0000269|PubMed:23112336}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected in thermosensory AFD neurons,
CC neurosecretory NSM cells, AVK interneurons, pharyngeal neuron M5, and
CC the mechanosensory DVA neuron (PubMed:23112336, PubMed:23112335).
CC Detected in male-specific CP motor neurons (PubMed:23112335).
CC {ECO:0000269|PubMed:23112335, ECO:0000269|PubMed:23112336}.
CC -!- MASS SPECTROMETRY: Mass=1418.64; Method=Unknown;
CC Evidence={ECO:0000269|PubMed:23112335};
CC -!- DISRUPTION PHENOTYPE: Viable and fertile (PubMed:23112336). Gustatory
CC associative learning in response to salt cues is disrupted
CC (PubMed:23112336). Males have reduced reproductive success, due to a
CC range of aberrant mating behaviors (PubMed:23112335).
CC {ECO:0000269|PubMed:23112335, ECO:0000269|PubMed:23112336}.
CC -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR EMBL; JQ277480; AFJ42491.1; -; mRNA.
DR EMBL; BX284606; CCD70849.1; -; Genomic_DNA.
DR RefSeq; NP_001033548.1; NM_001038459.1.
DR AlphaFoldDB; Q4R128; -.
DR SMR; Q4R128; -.
DR STRING; 6239.F39C12.4; -.
DR PaxDb; Q4R128; -.
DR EnsemblMetazoa; F39C12.4.1; F39C12.4.1; WBGene00044568.
DR GeneID; 3896872; -.
DR KEGG; cel:CELE_F39C12.4; -.
DR UCSC; F39C12.4; c. elegans.
DR CTD; 3896872; -.
DR WormBase; F39C12.4; CE38818; WBGene00044568; ntc-1.
DR eggNOG; ENOG502SYRY; Eukaryota.
DR HOGENOM; CLU_2374605_0_0_1; -.
DR InParanoid; Q4R128; -.
DR OMA; CCTQGGC; -.
DR OrthoDB; 1533614at2759; -.
DR PhylomeDB; Q4R128; -.
DR PRO; PR:Q4R128; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00044568; Expressed in larva and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR000981; Neurhyp_horm.
DR Pfam; PF00184; Hormone_5; 1.
PE 1: Evidence at protein level;
KW Amidation; Behavior; Direct protein sequencing; Disulfide bond;
KW Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PEPTIDE 20..30
FT /note="Nematocin"
FT /evidence="ECO:0000269|PubMed:23112335"
FT /id="PRO_5007703221"
FT PROPEP 31..103
FT /evidence="ECO:0000305"
FT /id="PRO_0000438123"
FT MOD_RES 30
FT /note="Tyrosine amide"
FT /evidence="ECO:0000269|PubMed:23112335"
FT DISULFID 20..25
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT MUTAGEN 28..30
FT /note="Missing: Fails to activate ntr-1."
FT /evidence="ECO:0000269|PubMed:23112336"
SQ SEQUENCE 103 AA; 11083 MW; 9F0C9022DEF15AAC CRC64;
MGSSPILLVL AISIGLASAC FLNSCPYRRY GRTIRCSSCG IENEGVCISE GRCCTNEECF
MSTECSYSAV CPELFCKIGH HPGYCMKKGY CCTQGGCQTS AMC
