ID   NTCA_SYNY3              Reviewed;         225 AA.
AC   P33779;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Global nitrogen regulator;
GN   Name=ntcA; OrderedLocusNames=sll1423;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8366058; DOI=10.1128/jb.175.17.5710-5713.1993;
RA   Frias J.E., Merida A., Herrero A., Martin-Nieto J.M., Flores E.;
RT   "General distribution of the nitrogen control gene ntcA in cyanobacteria.";
RL   J. Bacteriol. 175:5710-5713(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Required for full expression of proteins subject to ammonium
CC       repression. Transcriptional activator of genes subject to nitrogen
CC       control.
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DR   EMBL; X71607; CAA50607.1; -; Genomic_DNA.
DR   EMBL; BA000022; BAA18011.1; -; Genomic_DNA.
DR   PIR; A48640; A48640.
DR   AlphaFoldDB; P33779; -.
DR   SMR; P33779; -.
DR   IntAct; P33779; 1.
DR   STRING; 1148.1653095; -.
DR   PaxDb; P33779; -.
DR   EnsemblBacteria; BAA18011; BAA18011; BAA18011.
DR   KEGG; syn:sll1423; -.
DR   eggNOG; COG0664; Bacteria.
DR   InParanoid; P33779; -.
DR   OMA; VLCRDFG; -.
DR   PhylomeDB; P33779; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR018335; Tscrpt_reg_HTH_Crp-type_CS.
DR   InterPro; IPR022299; Tscrpt_reg_NtcA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   PRINTS; PR00034; HTHCRP.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00419; HTH_CRP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   TIGRFAMs; TIGR03697; NtcA_cyano; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS00042; HTH_CRP_1; 1.
DR   PROSITE; PS51063; HTH_CRP_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..225
FT                   /note="Global nitrogen regulator"
FT                   /id="PRO_0000100187"
FT   DOMAIN          145..218
FT                   /note="HTH crp-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   DNA_BIND        177..196
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   BINDING         9..131
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
SQ   SEQUENCE   225 AA;  25046 MW;  F1EE6555757E7379 CRC64;
     MDQSLTQDRP LAAVFRRLGS ELMPPVVETF DRSKTIFFPG DPAERVYFLL KGAVKLSRVY
     EAGEEITVAL LRENSVFGVL SLVTGQRSDR FYHAVAFTPV ELLSAPIEQV EQALKEHPDL
     SLLMLQGLSS RILQTEMMIE TLAHRDMGSR LVSFLLILCR DFGVPAPDGI RIDLKLSHQA
     IAEAIGSTRV TVTRLLGDLR EGNMISITKK KITVHNPVAL SQQFT