ID   NTCA_TRIV2              Reviewed;         223 AA.
AC   P0A4U7; Q05061; Q3M7Z5;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Global nitrogen regulator;
DE   AltName: Full=DNA-binding protein VF1;
DE   AltName: Full=Nitrogen-responsive regulatory protein;
GN   Name=ntcA; Synonyms=bifA; OrderedLocusNames=Ava_3283;
OS   Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Trichormus.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11114927; DOI=10.1128/jb.183.1.280-286.2001;
RA   Thiel T., Pratte B.;
RT   "Effect on heterocyst differentiation of nitrogen fixation in vegetative
RT   cells of the cyanobacterium Anabaena variabilis ATCC 29413.";
RL   J. Bacteriol. 183:280-286(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29413 / PCC 7937;
RX   PubMed=25197444; DOI=10.4056/sigs.3899418;
RA   Thiel T., Pratte B.S., Zhong J., Goodwin L., Copeland A., Lucas S., Han C.,
RA   Pitluck S., Land M.L., Kyrpides N.C., Woyke T.;
RT   "Complete genome sequence of Anabaena variabilis ATCC 29413.";
RL   Stand. Genomic Sci. 9:562-573(2014).
CC   -!- FUNCTION: Required for full expression of proteins subject to ammonium
CC       repression. Transcriptional activator of genes subject to nitrogen
CC       control.
CC   -!- FUNCTION: Has affinity for the xisA upstream region. Binds to a 66 bp
CC       region containing three repeats of the consensus recognition sequence
CC       5'-ACATT-3'.
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DR   EMBL; U89516; AAB49763.1; -; Genomic_DNA.
DR   EMBL; CP000117; ABA22891.1; -; Genomic_DNA.
DR   RefSeq; WP_010998529.1; NC_007413.1.
DR   AlphaFoldDB; P0A4U7; -.
DR   SMR; P0A4U7; -.
DR   STRING; 240292.Ava_3283; -.
DR   EnsemblBacteria; ABA22891; ABA22891; Ava_3283.
DR   GeneID; 58726067; -.
DR   KEGG; ava:Ava_3283; -.
DR   eggNOG; COG0664; Bacteria.
DR   HOGENOM; CLU_075053_3_2_3; -.
DR   OMA; VLCRDFG; -.
DR   Proteomes; UP000002533; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR018335; Tscrpt_reg_HTH_Crp-type_CS.
DR   InterPro; IPR022299; Tscrpt_reg_NtcA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   PRINTS; PR00034; HTHCRP.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00419; HTH_CRP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   TIGRFAMs; TIGR03697; NtcA_cyano; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS00042; HTH_CRP_1; 1.
DR   PROSITE; PS51063; HTH_CRP_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..223
FT                   /note="Global nitrogen regulator"
FT                   /id="PRO_0000100185"
FT   DOMAIN          143..216
FT                   /note="HTH crp-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   DNA_BIND        176..195
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
SQ   SEQUENCE   223 AA;  24918 MW;  07FCE891766E7021 CRC64;
     MIVTQDKALA NVFRQMATGA FPPVVETFER NKTIFFPGDP AERVYFLLKG AVKLSRVYEA
     GEEITVALLR ENSVFGVLSL LTGNKSDRFY HAVAFTPVEL LSAPIEQVEQ ALKENPELSM
     LMLRGLSSRI LQTEMMIETL AHRDMGSRLV SFLLILCRDF GVPCADGITI DLKLSHQAIA
     EAIGSTRVTV TRLLGDLREK KMISIHKKKI TVHKPVTLSR QFT