ID   NTCB_SYNY3              Reviewed;         309 AA.
AC   P74422;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Probable nitrogen assimilation transcriptional activator;
GN   Name=ntcB; OrderedLocusNames=slr0395;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Seems to regulate utilization of fixed nitrogen by
CC       controlling the expression of a certain gene(s) involved in nitrogen
CC       metabolism. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; BA000022; BAA18522.1; -; Genomic_DNA.
DR   PIR; S76393; S76393.
DR   AlphaFoldDB; P74422; -.
DR   SMR; P74422; -.
DR   STRING; 1148.1653610; -.
DR   PaxDb; P74422; -.
DR   EnsemblBacteria; BAA18522; BAA18522; BAA18522.
DR   KEGG; syn:slr0395; -.
DR   eggNOG; COG0583; Bacteria.
DR   InParanoid; P74422; -.
DR   OMA; GKQPELC; -.
DR   PhylomeDB; P74422; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..309
FT                   /note="Probable nitrogen assimilation transcriptional
FT                   activator"
FT                   /id="PRO_0000105726"
FT   DOMAIN          1..57
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   309 AA;  34847 MW;  40278EB8A3224D22 CRC64;
     MRLEQLQAFL KVAELGSFQQ AALQSEVTQS TISRQIQGLE SALKCQLFHR GAQAKLTVAG
     ELFLRRARKI CQEWDVASEE ISSLFQGKQT ELCVAAIHSV CVSSLPSLLP KFCLGHPQIQ
     LRVTALGSDR ALKVLQDGLV DVAIIMSHRN LTNTKELAIK PLYEEQICIL MASDHPLTTK
     KFITWENLGP YPQVIFKDGY RMRRLVEDEF SRREIPLNVS LELNIPEAFY GVVQGSEMIA
     LMPQSLVTPV IDNPNFSVRY LFCPESGDRQ DFRRQVSVVT TVDRLQIPPV AEFFNLVVDH
     YRCGALTVK