ID   NTCP2_CRIGR             Reviewed;         348 AA.
AC   Q60414;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Ileal sodium/bile acid cotransporter;
DE   AltName: Full=Apical sodium-dependent bile acid transporter;
DE            Short=ASBT;
DE   AltName: Full=Ileal Na(+)/bile acid cotransporter;
DE   AltName: Full=Ileal sodium-dependent bile acid transporter;
DE            Short=IBAT;
DE            Short=ISBT;
DE   AltName: Full=Na(+)-dependent ileal bile acid transporter;
DE   AltName: Full=Sodium/taurocholate cotransporting polypeptide, ileal;
DE   AltName: Full=Solute carrier family 10 member 2;
GN   Name=SLC10A2; Synonyms=NTCP2;
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ileum;
RX   PubMed=8288599; DOI=10.1016/s0021-9258(17)42263-0;
RA   Wong M.H., Oelkers P.M., Craddock A.L., Dawson P.A.;
RT   "Expression cloning and characterization of the hamster ileal sodium-
RT   dependent bile acid transporter.";
RL   J. Biol. Chem. 269:1340-1347(1994).
CC   -!- FUNCTION: Plays a critical role in the sodium-dependent reabsorption of
CC       bile acids from the lumen of the small intestine. Plays a key role in
CC       cholesterol metabolism (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer and homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC       2.A.28) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U02028; AAA18640.1; -; mRNA.
DR   RefSeq; NP_001233749.1; NM_001246820.1.
DR   AlphaFoldDB; Q60414; -.
DR   SMR; Q60414; -.
DR   STRING; 10029.XP_007634001.1; -.
DR   GeneID; 100689396; -.
DR   KEGG; cge:100689396; -.
DR   CTD; 6555; -.
DR   eggNOG; KOG2718; Eukaryota.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008508; F:bile acid:sodium symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR   InterPro; IPR004710; Bilac:Na_transpt.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR030207; SLC10A2.
DR   PANTHER; PTHR10361; PTHR10361; 1.
DR   PANTHER; PTHR10361:SF19; PTHR10361:SF19; 1.
DR   Pfam; PF01758; SBF; 1.
DR   TIGRFAMs; TIGR00841; bass; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion transport; Membrane; Phosphoprotein; Sodium;
KW   Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..348
FT                   /note="Ileal sodium/bile acid cotransporter"
FT                   /id="PRO_0000052338"
FT   TOPO_DOM        1..28
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..81
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..126
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        148..157
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        179..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..224
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        246..284
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        306..348
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          322..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         335
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P70172"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        10
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   348 AA;  37920 MW;  1F3A1CFC9C8DFB8C CRC64;
     MDNSSICNPN ATICEGDSCI APESNFNAIL SVVMSTVLTI LLALVMFSMG CNVELHKFLG
     HLRRPWGIVV GFLCQFGIMP LTGFVLSVAF GILPVQAVVV LIQGCCPGGT ASNILAYWVD
     GDMDLSVSMT TCSTLLALGM MPLCLFIYTK MWVDSGTIVI PYDSIGTSLV ALVIPVSIGM
     YVNHKWPQKA KIILKIGSIA GAILIVLIAV VGGILYQSAW TIEPKLWIIG TIYPIAGYGL
     GFFLARIAGQ PWYRCRTVAL ETGLQNTQLC STIVQLSFSP EDLNLVFTFP LIYSIFQIAF
     AAILLGAYVA YKKCHGKNNT ELQEKTDNEM EPRSSFQETN KGFQPDEK