NTCP2_RABIT
ID NTCP2_RABIT Reviewed; 347 AA.
AC Q28727;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Ileal sodium/bile acid cotransporter;
DE AltName: Full=Apical sodium-dependent bile acid transporter;
DE Short=ASBT;
DE AltName: Full=Ileal Na(+)/bile acid cotransporter;
DE AltName: Full=Ileal sodium-dependent bile acid transporter;
DE Short=IBAT;
DE Short=ISBT;
DE AltName: Full=Na(+)-dependent ileal bile acid transporter;
DE AltName: Full=Sodium/taurocholate cotransporting polypeptide, ileal;
DE AltName: Full=Solute carrier family 10 member 2;
GN Name=SLC10A2; Synonyms=NTCP2;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=New Zealand white; TISSUE=Ileum;
RA Stengelin S., Apel S., Becker W., Maier M., Rosenberger J., Wess G.,
RA Kramer W.;
RT "Cloning of the rabbit ileal sodium-dependent bile acid transporter.";
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a critical role in the sodium-dependent reabsorption of
CC bile acids from the lumen of the small intestine. Plays a key role in
CC cholesterol metabolism (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000305}.
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DR EMBL; Z54357; CAA91184.1; -; mRNA.
DR EMBL; AJ002005; CAA05135.1; -; Genomic_DNA.
DR RefSeq; NP_001076233.1; NM_001082764.1.
DR AlphaFoldDB; Q28727; -.
DR SMR; Q28727; -.
DR STRING; 9986.ENSOCUP00000004722; -.
DR Ensembl; ENSOCUT00000005444; ENSOCUP00000004722; ENSOCUG00000005443.
DR GeneID; 100009550; -.
DR KEGG; ocu:100009550; -.
DR CTD; 6555; -.
DR eggNOG; KOG2718; Eukaryota.
DR GeneTree; ENSGT00950000182808; -.
DR HOGENOM; CLU_034788_7_5_1; -.
DR InParanoid; Q28727; -.
DR OMA; QFTIMPL; -.
DR OrthoDB; 1148347at2759; -.
DR Proteomes; UP000001811; Chromosome 8.
DR Bgee; ENSOCUG00000005443; Expressed in kidney and 4 other tissues.
DR ExpressionAtlas; Q28727; baseline.
DR GO; GO:0016324; C:apical plasma membrane; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008508; F:bile acid:sodium symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR030207; SLC10A2.
DR PANTHER; PTHR10361; PTHR10361; 1.
DR PANTHER; PTHR10361:SF19; PTHR10361:SF19; 1.
DR Pfam; PF01758; SBF; 1.
DR TIGRFAMs; TIGR00841; bass; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome;
KW Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..347
FT /note="Ileal sodium/bile acid cotransporter"
FT /id="PRO_0000052341"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..127
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..225
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..289
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 323..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 336
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70172"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 347 AA; 37729 MW; 1315BB6BADDEE66C CRC64;
MSNLTVGCLA NATVCEGASC VAPESNFNAI LSVVLSTVLT ILLALVMFSM GCNVEIKKFL
GHIRRPWGIF IGFLCQFGIM PLTGFVLAVA FGIMPIQAVV VLIMGCCPGG TASNILAYWV
DGDMDLSVSM TTCSTLLALG MMPLCLYVYT KMWVDSGTIV IPYDNIGTSL VALVVPVSIG
MFVNHKWPQK AKIILKVGSI AGAVLIVLIA VVGGILYQSA WIIEPKLWII GTIFPMAGYS
LGFFLARIAG QPWYRCRTVA LETGMQNTQL CSTIVQLSFS PEDLTYVFTF PLIYSIFQIA
FAAIFLGIYV AYRKCHGKND AEFPDIKDTK TEPESSFHQM NGGFQPE
