NTCP2_RAT
ID NTCP2_RAT Reviewed; 348 AA.
AC Q62633;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Ileal sodium/bile acid cotransporter;
DE AltName: Full=Apical sodium-dependent bile acid transporter;
DE Short=ASBT;
DE AltName: Full=Ileal Na(+)/bile acid cotransporter;
DE AltName: Full=Ileal sodium-dependent bile acid transporter;
DE Short=IBAT;
DE Short=ISBT;
DE AltName: Full=Na(+)-dependent ileal bile acid transporter;
DE AltName: Full=Sodium/taurocholate-cotransporting polypeptide, ileal;
DE AltName: Full=Solute carrier family 10 member 2;
GN Name=Slc10a2; Synonyms=Ntcp2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Ileum;
RX PubMed=7860756; DOI=10.1172/jci117722;
RA Shneider B.L., Dawson P.A., Christie D.M., Hardikar W., Wong M.H.,
RA Suchy F.J.;
RT "Cloning and molecular characterization of the ontogeny of a rat ileal
RT sodium-dependent bile acid transporter.";
RL J. Clin. Invest. 95:745-754(1995).
CC -!- FUNCTION: Plays a critical role in the sodium-dependent reabsorption of
CC bile acids from the lumen of the small intestine. Plays a key role in
CC cholesterol metabolism (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- DEVELOPMENTAL STAGE: Transcriptionally regulated increases in mRNA and
CC protein levels at the time of weaning.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000305}.
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DR EMBL; U07183; AAC53101.1; -; mRNA.
DR RefSeq; NP_058918.1; NM_017222.2.
DR RefSeq; XP_017455542.1; XM_017600053.1.
DR AlphaFoldDB; Q62633; -.
DR SMR; Q62633; -.
DR STRING; 10116.ENSRNOP00000054127; -.
DR BindingDB; Q62633; -.
DR ChEMBL; CHEMBL2073686; -.
DR GlyGen; Q62633; 2 sites.
DR iPTMnet; Q62633; -.
DR PhosphoSitePlus; Q62633; -.
DR PaxDb; Q62633; -.
DR DNASU; 29500; -.
DR Ensembl; ENSRNOT00000100219; ENSRNOP00000095418; ENSRNOG00000037753.
DR Ensembl; ENSRNOT00000113335; ENSRNOP00000088268; ENSRNOG00000037753.
DR GeneID; 29500; -.
DR KEGG; rno:29500; -.
DR UCSC; RGD:3682; rat.
DR CTD; 6555; -.
DR RGD; 3682; Slc10a2.
DR eggNOG; KOG2718; Eukaryota.
DR GeneTree; ENSGT00950000182808; -.
DR InParanoid; Q62633; -.
DR OrthoDB; 1148347at2759; -.
DR PhylomeDB; Q62633; -.
DR TreeFam; TF315811; -.
DR Reactome; R-RNO-159418; Recycling of bile acids and salts.
DR PRO; PR:Q62633; -.
DR Proteomes; UP000002494; Chromosome 16.
DR GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005902; C:microvillus; ISO:RGD.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0000502; C:proteasome complex; IDA:RGD.
DR GO; GO:0008508; F:bile acid:sodium symporter activity; IDA:RGD.
DR GO; GO:0015721; P:bile acid and bile salt transport; IDA:RGD.
DR GO; GO:0008206; P:bile acid metabolic process; TAS:RGD.
DR GO; GO:0009617; P:response to bacterium; ISO:RGD.
DR GO; GO:0006814; P:sodium ion transport; TAS:RGD.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR030207; SLC10A2.
DR PANTHER; PTHR10361; PTHR10361; 1.
DR PANTHER; PTHR10361:SF19; PTHR10361:SF19; 1.
DR Pfam; PF01758; SBF; 1.
DR TIGRFAMs; TIGR00841; bass; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome;
KW Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..348
FT /note="Ileal sodium/bile acid cotransporter"
FT /id="PRO_0000052342"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..126
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..348
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 327..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 335
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70172"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 348 AA; 38024 MW; D4C38CF136D1143B CRC64;
MDNSSVCSPN ATFCEGDSCL VTESNFNAIL STVMSTVLTI LLAMVMFSMG CNVEINKFLG
HIKRPWGIFV GFLCQFGIMP LTGFILSVAS GILPVQAVVV LIMGCCPGGT GSNILAYWID
GDMDLSVSMT TCSTLLALGM MPLCLFIYTK MWVDSGTIVI PYDSIGISLV ALVIPVSIGM
FVNHKWPQKA KIILKIGSIA GAILIVLIAV VGGILYQSAW IIEPKLWIIG TIFPIAGYSL
GFFLARLAGQ PWYRCRTVAL ETGMQNTQLC STIVQLSFSP EDLNLVFTFP LIYTVFQLVF
AAIILGMYVT YKKCHGKNDA EFLEKTDNDM DPMPSFQETN KGFQPDEK
