NTCP4_RAT
ID NTCP4_RAT Reviewed; 437 AA.
AC Q5PT56;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Sodium/bile acid cotransporter 4;
DE AltName: Full=Na(+)/bile acid cotransporter 4;
DE AltName: Full=Solute carrier family 10 member 4;
GN Name=Slc10a4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Mikkaichi T., Abe T., Hishinuma T., Goto J.;
RT "Identification of a novel bile acid transporter in rat, Slc10a4.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TOPOLOGY, AND TISSUE SPECIFICITY.
RC STRAIN=Wistar; TISSUE=Adrenal gland;
RX PubMed=18355966; DOI=10.1016/j.neuroscience.2008.01.049;
RA Geyer J., Fernandes C.F., Doring B., Burger S., Godoy J.R., Rafalzik S.,
RA Hubschle T., Gerstberger R., Petzinger E.;
RT "Cloning and molecular characterization of the orphan carrier protein
RT Slc10a4: expression in cholinergic neurons of the rat central nervous
RT system.";
RL Neuroscience 152:990-1005(2008).
CC -!- FUNCTION: Transporter for bile acids. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Mainly expressed in the central nervous system
CC cholinergic neurons. Expressed (at protein level) in motor regions of
CC the spinal cord and rhombencephalon, in mesopontine cholinergic
CC neurons, the medial habenula, cholinergic areas of the forebrain, and
CC the gut myenteric plexus. {ECO:0000269|PubMed:18355966}.
CC -!- PTM: Activated following N-terminal proteolytic cleavage by thrombin
CC and/or proteases. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000305}.
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DR EMBL; AY704415; AAW30131.1; -; mRNA.
DR EMBL; AY825923; AAV80706.1; -; mRNA.
DR RefSeq; NP_001008555.1; NM_001008555.1.
DR AlphaFoldDB; Q5PT56; -.
DR SMR; Q5PT56; -.
DR STRING; 10116.ENSRNOP00000037495; -.
DR GlyGen; Q5PT56; 5 sites.
DR PaxDb; Q5PT56; -.
DR GeneID; 305309; -.
DR KEGG; rno:305309; -.
DR UCSC; RGD:1309536; rat.
DR CTD; 201780; -.
DR RGD; 1309536; Slc10a4.
DR eggNOG; KOG2718; Eukaryota.
DR InParanoid; Q5PT56; -.
DR OrthoDB; 1148347at2759; -.
DR PhylomeDB; Q5PT56; -.
DR PRO; PR:Q5PT56; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0098981; C:cholinergic synapse; ISO:RGD.
DR GO; GO:0098691; C:dopaminergic synapse; ISO:RGD.
DR GO; GO:0030285; C:integral component of synaptic vesicle membrane; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0099154; C:serotonergic synapse; ISO:RGD.
DR GO; GO:0008508; F:bile acid:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0030534; P:adult behavior; ISO:RGD.
DR GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR GO; GO:0099162; P:regulation of neurotransmitter loading into synaptic vesicle; ISO:RGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; ISO:RGD.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR030204; SLC10A4.
DR PANTHER; PTHR10361; PTHR10361; 1.
DR PANTHER; PTHR10361:SF41; PTHR10361:SF41; 1.
DR Pfam; PF01758; SBF; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..437
FT /note="Sodium/bile acid cotransporter 4"
FT /id="PRO_0000263744"
FT TOPO_DOM 1..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..291
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..360
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..437
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 16..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 87..88
FT /note="Cleavage; by thrombin"
FT /evidence="ECO:0000250"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 181
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 437 AA; 46614 MW; 5D5CB8ECC311D563 CRC64;
MDGLDNTTRL LAPSSLLPDN LTLSPNASST SASTLSPLPV TSSPSPGLSL APTPSIGFSP
DLTPTPEPTS SSLAGGVAGQ DSSTFPRPWI PHEPPFWDTP LNHGLNVFVG AALCITMLGL
GCTVDVNHFG AHVRRPVGAL LAALCQFGFL PLLAFLLALA FKLDEVAAVA VLLCGCCPGG
NLSNLMSLLV DGDMNLSIIM TISSTLLALV LMPLCLWIYS RAWINTPLVQ LLPLGAVTLT
LCSTLIPIGL GVFIRYKYNR VADYIVKVSL CSLLVTLVVL FIMTGTMLGP ELLASIPAAV
YVVAIFMPLA GYASGYGLAT LFHLPPNCKR TVCLETGSQN VQLCTAILKL AFPPRFIGSM
YMFPLLYALF QSAEAGVFVL IYKMYGSEIL HKREALDEDD DTDISYKKLK EEELADTSYG
TVGTDDLVLM ETTQTSL
