NTCP5_MOUSE
ID NTCP5_MOUSE Reviewed; 434 AA.
AC Q5PT54; B9EJ85;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Sodium/bile acid cotransporter 5;
DE AltName: Full=Na(+)/bile acid cotransporter 5;
DE AltName: Full=Solute carrier family 10 member 5;
DE Flags: Precursor;
GN Name=Slc10a5; Synonyms=Gm405;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver;
RA Fernandes C., Geyer J., Petzinger E.;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000305}.
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DR EMBL; AY825925; AAV80708.1; -; mRNA.
DR EMBL; AK143900; BAE25589.1; -; mRNA.
DR EMBL; BC141377; AAI41378.1; -; mRNA.
DR CCDS; CCDS17241.1; -.
DR RefSeq; NP_001010834.1; NM_001010834.2.
DR AlphaFoldDB; Q5PT54; -.
DR SMR; Q5PT54; -.
DR STRING; 10090.ENSMUSP00000077808; -.
DR GlyGen; Q5PT54; 2 sites.
DR iPTMnet; Q5PT54; -.
DR PhosphoSitePlus; Q5PT54; -.
DR SwissPalm; Q5PT54; -.
DR MaxQB; Q5PT54; -.
DR PaxDb; Q5PT54; -.
DR PRIDE; Q5PT54; -.
DR ProteomicsDB; 253032; -.
DR Antibodypedia; 50193; 36 antibodies from 17 providers.
DR DNASU; 241877; -.
DR Ensembl; ENSMUST00000078748; ENSMUSP00000077808; ENSMUSG00000058921.
DR GeneID; 241877; -.
DR KEGG; mmu:241877; -.
DR UCSC; uc008opr.1; mouse.
DR CTD; 347051; -.
DR MGI; MGI:2685251; Slc10a5.
DR VEuPathDB; HostDB:ENSMUSG00000058921; -.
DR eggNOG; KOG2718; Eukaryota.
DR GeneTree; ENSGT00950000182808; -.
DR HOGENOM; CLU_034788_2_0_1; -.
DR InParanoid; Q5PT54; -.
DR OMA; TMPLWIF; -.
DR OrthoDB; 1148347at2759; -.
DR PhylomeDB; Q5PT54; -.
DR TreeFam; TF315811; -.
DR BioGRID-ORCS; 241877; 0 hits in 74 CRISPR screens.
DR PRO; PR:Q5PT54; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q5PT54; protein.
DR Bgee; ENSMUSG00000058921; Expressed in proximal tubule and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008508; F:bile acid:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR030209; SLC10A5.
DR PANTHER; PTHR10361; PTHR10361; 1.
DR PANTHER; PTHR10361:SF29; PTHR10361:SF29; 1.
DR Pfam; PF01758; SBF; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Signal; Sodium;
KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..434
FT /note="Sodium/bile acid cotransporter 5"
FT /id="PRO_0000263746"
FT TOPO_DOM 19..129
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..331
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 353..365
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 387..395
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 417..434
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 434 AA; 48123 MW; 9F920478E8BBB40F CRC64;
MSGNFFIFLL LLVTPGEAKK SFLSFLNIQN TEMLSFTRTE ENIVVRSSYK DKQPHSSYLL
VKLEDPKVLQ VVNVTKTSLA VTDFTVNLKT FPGETNVTLQ LWESEGRQTT LIDELKNVRV
RVFRQTDDSL LQAPIHVDSS IFLLVLSMIL LNKCAFGCKI EFQVLQTVWK RPLPILLGVV
IQFFLMPFCG FLLSQILGLP KAQAFGFVMT CTCPGGGGGY LFALLLEGDV TLAILMTCTS
TSLALIMMPV NSYFYSRLLG LAGAFHVPVL KIVSTLLFIL MPMSTGVIIK HKMPAKAICL
ERVVRPLSLT LMFVGIYLAF RMGLVFLRMA NLEVFLLGLL VPALGLLFGY SLAKVYLLPL
PVCKTVALET GMLNSFLALA IIQLSFSQPK AHEASVAPFT VAMCSSCEML LLLLVYKAKR
RPSLSTEYEK TPLV
