ID   NTCP5_RAT               Reviewed;         434 AA.
AC   Q4JLT5;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Sodium/bile acid cotransporter 5;
DE   AltName: Full=Na(+)/bile acid cotransporter 5;
DE   AltName: Full=Solute carrier family 10 member 5;
DE   Flags: Precursor;
GN   Name=Slc10a5; Synonyms=P5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Small intestine;
RA   Fernandes C., Geyer J., Petzinger E.;
RT   "Cloning of P5 from rat small intestine.";
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC       2.A.28) family. {ECO:0000305}.
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DR   EMBL; DQ074435; AAY85181.1; -; mRNA.
DR   RefSeq; NP_001020451.1; NM_001025280.1.
DR   AlphaFoldDB; Q4JLT5; -.
DR   SMR; Q4JLT5; -.
DR   IntAct; Q4JLT5; 1.
DR   STRING; 10116.ENSRNOP00000051406; -.
DR   GlyGen; Q4JLT5; 2 sites.
DR   iPTMnet; Q4JLT5; -.
DR   PhosphoSitePlus; Q4JLT5; -.
DR   PaxDb; Q4JLT5; -.
DR   GeneID; 310230; -.
DR   KEGG; rno:310230; -.
DR   UCSC; RGD:1306036; rat.
DR   CTD; 347051; -.
DR   RGD; 1306036; Slc10a5.
DR   eggNOG; KOG2718; Eukaryota.
DR   InParanoid; Q4JLT5; -.
DR   OrthoDB; 1148347at2759; -.
DR   PhylomeDB; Q4JLT5; -.
DR   PRO; PR:Q4JLT5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008508; F:bile acid:sodium symporter activity; IBA:GO_Central.
DR   GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR   InterPro; IPR004710; Bilac:Na_transpt.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR030209; SLC10A5.
DR   PANTHER; PTHR10361; PTHR10361; 1.
DR   PANTHER; PTHR10361:SF29; PTHR10361:SF29; 1.
DR   Pfam; PF01758; SBF; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion transport; Membrane; Reference proteome; Signal; Sodium;
KW   Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..434
FT                   /note="Sodium/bile acid cotransporter 5"
FT                   /id="PRO_0000263747"
FT   TOPO_DOM        19..129
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        151..172
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        194..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..232
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..268
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..306
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        328..331
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        353..365
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        387..395
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        417..434
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        96
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   434 AA;  48076 MW;  AE4915A71E752796 CRC64;
     MSGKLFIILL LLVTPGEARK SFLRFLNIQN PEMLSFTKPE ETVIVRSSYE GKRPHSSYLL
     VKLEDPTVLQ VVNVTKTSLD FTDFTINLKT FPGETNLTMQ LWESEGRQTR LIEEITNIRV
     SVFRQTEDSL FQEPIHVNSS VFLLVLLMIL LNKCAFGCKI ELQVLQTVWK RPLPILLGAV
     TQFFLMPFCG FLLSQILGLS KAQAFGFVMT CTCPGGGGGY LFALLLEGDV TLAILMACTS
     TSLALIMMPV NSYLYSCLLG LAGVFHVPVL KIVSTLLFIL TPVSIGIVIK HRMPKKAVCL
     ERVVQPLSLT LMLVGVYLAF RMGLVFLRMA NLEVFLLGLL VPVLGFSFGY SFAKVYLLPL
     PVCKTVAIES GMLNSFLALA IIQLSFPQSK AYEASVAPFT VAMCSSCEML LLLLVYKAKK
     RPLLSTENEK APLV