NTCP7_CHICK
ID NTCP7_CHICK Reviewed; 333 AA.
AC Q5ZJH8;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Sodium/bile acid cotransporter 7;
DE AltName: Full=Na(+)/bile acid cotransporter 7;
DE AltName: Full=Solute carrier family 10 member 7;
GN Name=SLC10A7; ORFNames=RCJMB04_18a5;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Involved in teeth and skeletal development. Has an essential
CC role in the biosynthesis and trafficking of glycosaminoglycans and
CC glycoproteins to produce a proper functioning extracellular matrix.
CC Required for extracellular matrix mineralization. Also involved in the
CC regulation of cellular calcium homeostasis. Does not show transport
CC activity towards bile acids or steroid sulfates.
CC {ECO:0000250|UniProtKB:Q0GE19}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q0GE19};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q0GE19}. Endoplasmic
CC reticulum membrane {ECO:0000250|UniProtKB:Q0GE19}; Multi-pass membrane
CC protein {ECO:0000250|UniProtKB:Q0GE19}. Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q0GE19}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000305}.
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DR EMBL; AJ720456; CAG32115.1; -; mRNA.
DR RefSeq; NP_001026302.1; NM_001031131.1.
DR AlphaFoldDB; Q5ZJH8; -.
DR SMR; Q5ZJH8; -.
DR STRING; 9031.ENSGALP00000037778; -.
DR PaxDb; Q5ZJH8; -.
DR Ensembl; ENSGALT00000038572; ENSGALP00000037779; ENSGALG00000010006.
DR GeneID; 422467; -.
DR KEGG; gga:422467; -.
DR CTD; 84068; -.
DR VEuPathDB; HostDB:geneid_422467; -.
DR eggNOG; KOG4821; Eukaryota.
DR GeneTree; ENSGT00390000011932; -.
DR InParanoid; Q5ZJH8; -.
DR PhylomeDB; Q5ZJH8; -.
DR PRO; PR:Q5ZJH8; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000010006; Expressed in colon and 12 other tissues.
DR ExpressionAtlas; Q5ZJH8; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR016833; Put_Na-Bile_cotransptr.
DR PANTHER; PTHR18640; PTHR18640; 1.
DR Pfam; PF13593; SBF_like; 1.
DR PIRSF; PIRSF026166; UCP026166; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Endoplasmic reticulum; Golgi apparatus; Ion transport;
KW Membrane; Reference proteome; Sodium; Sodium transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..333
FT /note="Sodium/bile acid cotransporter 7"
FT /id="PRO_0000278253"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..37
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..103
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..151
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..189
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..222
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..258
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..286
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
SQ SEQUENCE 333 AA; 36777 MW; 17C4B6376A4FE039 CRC64;
MGLLERLRKE WFIAGIALVI AAARLEPAVG VKGGPLKPEI TITYIAVSAI FFNSGLSLKT
EELTSALMHV KLHLFVQIFT LVFFPTAIWL FLQLLSITPI NEWLLKGLQT VGCMPPPVSS
AVILTKAVGG NEAAAIFNSA FGSFLLGSSS SVPFTSIFSQ LFMTVVVPLI IGQIVRRYIK
DWLERRKPPF GTISSCVLLM IIYTTFCDTF ANPNIDLDKF SLIIIVFIIF SVQMSFMFLT
FLFSTRSNSG FTPADTVAII FCSTHKSLTL GIPMLKIVFA GYEHLSLISV PLLIYHPAQI
LLGSLLVPTI KSWMVSRQKA LKLTRQPKVP VKV
