NTCP7_DANRE
ID NTCP7_DANRE Reviewed; 336 AA.
AC Q6DHK8;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Sodium/bile acid cotransporter 7;
DE AltName: Full=Na(+)/bile acid cotransporter 7;
DE AltName: Full=Solute carrier family 10 member 7;
GN Name=slc10a7; ORFNames=zgc:92251;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=29878199; DOI=10.1093/hmg/ddy213;
RG CDG group;
RA Ashikov A., Abu Bakar N., Wen X.Y., Niemeijer M.,
RA Rodrigues Pinto Osorio G., Brand-Arzamendi K., Hasadsri L., Hansikova H.,
RA Raymond K., Vicogne D., Ondruskova N., Simon M.E.H., Pfundt R., Timal S.,
RA Beumers R., Biot C., Smeets R., Kersten M., Huijben K., Linders P.T.A.,
RA van den Bogaart G., van Hijum S.A.F.T., Rodenburg R., van den Heuvel L.P.,
RA van Spronsen F., Honzik T., Foulquier F., van Scherpenzeel M.,
RA Lefeber D.J., Mirjam W., Han B., Helen M., Helen M., Peter V.H.,
RA Jiddeke V.K., Diego M., Lars M., Katja B.H., Jozef H., Majid A., Kevin C.,
RA Johann T.W.N.;
RT "Integrating glycomics and genomics uncovers SLC10A7 as essential factor
RT for bone mineralization by regulating post-Golgi protein transport and
RT glycosylation.";
RL Hum. Mol. Genet. 27:3029-3045(2018).
CC -!- FUNCTION: Involved in teeth and skeletal development (PubMed:29878199).
CC Has an essential role in the biosynthesis and trafficking of
CC glycosaminoglycans and glycoproteins to produce a proper functioning
CC extracellular matrix (By similarity). Required for extracellular matrix
CC mineralization (PubMed:29878199). Also involved in the regulation of
CC cellular calcium homeostasis (By similarity). Does not show transport
CC activity towards bile acids or steroid sulfates.
CC {ECO:0000250|UniProtKB:Q0GE19, ECO:0000269|PubMed:29878199}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q0GE19};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q0GE19}. Endoplasmic
CC reticulum membrane {ECO:0000250|UniProtKB:Q0GE19}; Multi-pass membrane
CC protein {ECO:0000250|UniProtKB:Q0GE19}. Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q0GE19}.
CC -!- DISRUPTION PHENOTYPE: Morphants have reduced head and eyes, a curled
CC body, tooth cartilage that is bent downwards, reduced Meckel cartilage,
CC absence of the fourth ceratobranchial cartilage, shortened or absent
CC palate cartilage, widened palatal skeleton, reduced cleithrum,
CC notochord, and lack of bone mineralization.
CC {ECO:0000269|PubMed:29878199}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000305}.
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DR EMBL; BC075962; AAH75962.1; -; mRNA.
DR RefSeq; NP_001003420.1; NM_001003420.1.
DR AlphaFoldDB; Q6DHK8; -.
DR SMR; Q6DHK8; -.
DR STRING; 7955.ENSDARP00000012513; -.
DR PaxDb; Q6DHK8; -.
DR Ensembl; ENSDART00000168646; ENSDARP00000131861; ENSDARG00000104508.
DR GeneID; 445025; -.
DR KEGG; dre:445025; -.
DR CTD; 84068; -.
DR ZFIN; ZDB-GENE-040801-5; slc10a7.
DR eggNOG; KOG4821; Eukaryota.
DR GeneTree; ENSGT00390000011932; -.
DR HOGENOM; CLU_039013_0_0_1; -.
DR InParanoid; Q6DHK8; -.
DR OMA; FFFYGLK; -.
DR OrthoDB; 949808at2759; -.
DR PhylomeDB; Q6DHK8; -.
DR TreeFam; TF329411; -.
DR PRO; PR:Q6DHK8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 23.
DR Bgee; ENSDARG00000104508; Expressed in blastula and 28 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0030282; P:bone mineralization; IMP:ZFIN.
DR GO; GO:0051216; P:cartilage development; IMP:ZFIN.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR016833; Put_Na-Bile_cotransptr.
DR PANTHER; PTHR18640; PTHR18640; 1.
DR Pfam; PF13593; SBF_like; 1.
DR PIRSF; PIRSF026166; UCP026166; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Endoplasmic reticulum; Golgi apparatus; Ion transport;
KW Membrane; Reference proteome; Sodium; Sodium transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..336
FT /note="Sodium/bile acid cotransporter 7"
FT /id="PRO_0000278254"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..37
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..116
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..163
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..233
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..298
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..336
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
SQ SEQUENCE 336 AA; 36838 MW; CED01EE5CE583B08 CRC64;
MGLIARVRKE WFIIGIVLVI TFAKLQPSVG VKGGPLHPEI TITYVAVSVI FFNSGLSLKT
EELASALMHV KLHFFVQTFT LVFFPIAIWL LLKVLALTAI NEWLLRGLQT VACMPPPVSS
AVILTKAVGG NEAAAIFNSA FGSFLGIVVT PLLLLVFLGS SSSVPFTSIF SQLFMTVVVP
LIVGQVCRRF LRECLDRRKP PFGAVSSVVL LMIIYSTFCD TFNNPNIELD HLSLLTVVFI
IFSIQLSFMA LIFFLSTRKS SGFSAADSVA IMFCATHKSL TLGIPMLKIV FEGYEHLSLI
SVPLLIYHPA QILLGSVLLP SIKTWMSGRQ KTLTPI
