NTCP7_RAT
ID NTCP7_RAT Reviewed; 340 AA.
AC Q5PT50;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Sodium/bile acid cotransporter 7;
DE AltName: Full=Na(+)/bile acid cotransporter 7;
DE AltName: Full=Solute carrier family 10 member 7;
GN Name=Slc10a7; Synonyms=P7;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP TOPOLOGY.
RC STRAIN=Wistar; TISSUE=Colon;
RX PubMed=17628207; DOI=10.1016/j.ejcb.2007.06.001;
RA Godoy J.R., Fernandes C., Doering B., Beuerlein K., Petzinger E., Geyer J.;
RT "Molecular and phylogenetic characterization of a novel putative membrane
RT transporter (SLC10A7), conserved in vertebrates and bacteria.";
RL Eur. J. Cell Biol. 86:445-460(2007).
CC -!- FUNCTION: Involved in teeth and skeletal development. Has an essential
CC role in the biosynthesis and trafficking of glycosaminoglycans and
CC glycoproteins to produce a proper functioning extracellular matrix.
CC Required for extracellular matrix mineralization. Also involved in the
CC regulation of cellular calcium homeostasis. Does not show transport
CC activity towards bile acids or steroid sulfates (including
CC taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate,
CC dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate).
CC {ECO:0000250|UniProtKB:Q0GE19}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17628207};
CC Multi-pass membrane protein {ECO:0000305|PubMed:17628207}. Endoplasmic
CC reticulum membrane {ECO:0000269|PubMed:17628207}; Multi-pass membrane
CC protein {ECO:0000305|PubMed:17628207}. Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q0GE19}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in liver, adrenal gland, small
CC intestine and colon. Moderately expressed in heart, lung, kidney and
CC spleen. Weakly expressed in brain. {ECO:0000269|PubMed:17628207}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000305}.
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DR EMBL; AY825929; AAV80712.1; -; mRNA.
DR RefSeq; NP_001010948.1; NM_001010948.1.
DR AlphaFoldDB; Q5PT50; -.
DR SMR; Q5PT50; -.
DR STRING; 10116.ENSRNOP00000015985; -.
DR PaxDb; Q5PT50; -.
DR Ensembl; ENSRNOT00000097147; ENSRNOP00000077134; ENSRNOG00000011991.
DR GeneID; 291942; -.
DR KEGG; rno:291942; -.
DR UCSC; RGD:1564388; rat.
DR CTD; 84068; -.
DR RGD; 1564388; Slc10a7.
DR eggNOG; KOG4821; Eukaryota.
DR GeneTree; ENSGT00390000011932; -.
DR HOGENOM; CLU_039013_0_0_1; -.
DR InParanoid; Q5PT50; -.
DR OMA; FFFYGLK; -.
DR OrthoDB; 949808at2759; -.
DR PhylomeDB; Q5PT50; -.
DR PRO; PR:Q5PT50; -.
DR Proteomes; UP000002494; Chromosome 19.
DR Bgee; ENSRNOG00000011991; Expressed in stomach and 19 other tissues.
DR Genevisible; Q5PT50; RN.
DR GO; GO:0005801; C:cis-Golgi network; ISS:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR GO; GO:0005797; C:Golgi medial cisterna; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR GO; GO:0015125; F:bile acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0060348; P:bone development; ISO:RGD.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; ISO:RGD.
DR GO; GO:0034436; P:glycoprotein transport; ISS:UniProtKB.
DR GO; GO:0048193; P:Golgi vesicle transport; ISS:UniProtKB.
DR GO; GO:0030210; P:heparin biosynthetic process; ISO:RGD.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR016833; Put_Na-Bile_cotransptr.
DR PANTHER; PTHR18640; PTHR18640; 1.
DR Pfam; PF13593; SBF_like; 1.
DR PIRSF; PIRSF026166; UCP026166; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Endoplasmic reticulum; Golgi apparatus; Ion transport;
KW Membrane; Reference proteome; Sodium; Sodium transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..340
FT /note="Sodium/bile acid cotransporter 7"
FT /id="PRO_0000278252"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:17628207"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..37
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:17628207"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:17628207"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..116
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:17628207"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:17628207"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..163
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:17628207"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:17628207"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..234
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:17628207"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:17628207"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..298
FT /note="Extracellular"
FT /evidence="ECO:0000269|PubMed:17628207"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..340
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:17628207"
SQ SEQUENCE 340 AA; 37316 MW; 9AB2E1DCD9C980D7 CRC64;
MRLLERVRKE WFMVGIVVAI GAAKLEPSVG VNGGPLKPEI TVSYIAVATI FFNSGLSLKT
EELTSALVHL KLHLFIQVFT LAFFPTTIWL FLQLLSVTSI NEWLLKGLQT VGCMPPPVSS
AVILTKAVGG NEAAAIFNSA FGSFLGIVVT PVLLLLFLGS SSSVPFTSIF SQLFMTVVVP
LVIGQIVRRY IKDWLERKKP PFGVVSSSVL LMIIYTTFCD TFSNPNIDLD KFSLILILFI
IVSIQLSFML LTFVFSTRNN SGFTPADTVA IIFCSTHKSL TLGIPMLKIV FAGHEHLSLI
SLPLLIYHPA QILLGSVLVP TIKSWMVSRQ KGVKLTRPTV
