NTCP7_XENTR
ID NTCP7_XENTR Reviewed; 343 AA.
AC Q28HF8; Q6DIM4;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Sodium/bile acid cotransporter 7;
DE AltName: Full=Na(+)/bile acid cotransporter 7;
DE AltName: Full=Solute carrier family 10 member 7;
GN Name=slc10a7; ORFNames=TTpA006l10.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Tadpole;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in teeth and skeletal development. Has an essential
CC role in the biosynthesis and trafficking of glycosaminoglycans and
CC glycoproteins to produce a proper functioning extracellular matrix.
CC Required for extracellular matrix mineralization. Also involved in the
CC regulation of cellular calcium homeostasis. Does not show transport
CC activity towards bile acids or steroid sulfates.
CC {ECO:0000250|UniProtKB:Q0GE19}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q0GE19};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q0GE19}. Endoplasmic
CC reticulum membrane {ECO:0000250|UniProtKB:Q0GE19}; Multi-pass membrane
CC protein {ECO:0000250|UniProtKB:Q0GE19}. Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q0GE19}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q28HF8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q28HF8-2; Sequence=VSP_023227, VSP_023228;
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR760903; CAJ82934.1; -; mRNA.
DR EMBL; BC075513; AAH75513.1; -; mRNA.
DR RefSeq; NP_001004977.2; NM_001004977.2. [Q28HF8-1]
DR AlphaFoldDB; Q28HF8; -.
DR SMR; Q28HF8; -.
DR GeneID; 448418; -.
DR KEGG; xtr:448418; -.
DR CTD; 84068; -.
DR Xenbase; XB-GENE-489389; slc10a7.
DR InParanoid; Q28HF8; -.
DR OrthoDB; 949808at2759; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000007119; Expressed in egg cell and 13 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR016833; Put_Na-Bile_cotransptr.
DR PANTHER; PTHR18640; PTHR18640; 1.
DR Pfam; PF13593; SBF_like; 1.
DR PIRSF; PIRSF026166; UCP026166; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Endoplasmic reticulum;
KW Golgi apparatus; Ion transport; Membrane; Reference proteome; Sodium;
KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..343
FT /note="Sodium/bile acid cotransporter 7"
FT /id="PRO_0000278257"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..37
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..116
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..163
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..234
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..298
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q0GE19"
FT VAR_SEQ 109..136
FT /note="QTVSCMPPPVSSAVILTKAVGGNEAAAI -> PLFSTLHLEVSWQCSRDSDS
FT RNSSSSCC (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_023227"
FT VAR_SEQ 137..343
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_023228"
SQ SEQUENCE 343 AA; 37812 MW; EAF877E419449DE9 CRC64;
MGLLERLRKE WFIVGIILVI AAAKLEPTIG GKGGPLKPEI TITYIAVSAI FFNSGLSLKT
EELTNALMHV KLHLFVQLFT LVFFPTAIWV FLQVLSLTPI NEWLLKGLQT VSCMPPPVSS
AVILTKAVGG NEAAAIFNSA FGSFLGIVVT PLLLLLFLGS SSSVPFTSIF SQLFMTVVVP
LIIGQIVRRY IKDWLERKKP PFGAISSCVL LMIIYTTFCD TFSNPNIDLD TFSLVIIVFI
IFFIQLAFML LTFLFSTSKN TGFTPADTVA IVFCSTHKSL TLGIPMLKIV FAGYEHLSLI
SVPLLIYHPA QILLGSVLVP TIKSWMLSRQ KALKLTRQPK VPL
