NTDR_BACSU
ID NTDR_BACSU Reviewed; 329 AA.
AC O07567; Q796R9;
DT 02-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=NTD biosynthesis operon regulator NtdR;
GN Name=ntdR; Synonyms=yhjM; OrderedLocusNames=BSU10560;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA Venema G., Bron S.;
RT "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL Microbiology 144:859-875(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION.
RC STRAIN=168 / 61884;
RX PubMed=14612444; DOI=10.1074/jbc.m309925200;
RA Inaoka T., Takahashi K., Yada H., Yoshida M., Ochi K.;
RT "RNA polymerase mutation activates the production of a dormant antibiotic
RT 3,3'-neotrehalosadiamine via an autoinduction mechanism in Bacillus
RT subtilis.";
RL J. Biol. Chem. 279:3885-3892(2004).
CC -!- FUNCTION: Positively regulates the ntdABC operon and negatively
CC regulates its own transcription. Binds to NTD to induce ntdABC
CC transcription. {ECO:0000269|PubMed:14612444}.
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DR EMBL; Y14081; CAA74475.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12896.1; -; Genomic_DNA.
DR PIR; D69834; D69834.
DR RefSeq; NP_388937.1; NC_000964.3.
DR RefSeq; WP_009966948.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; O07567; -.
DR SMR; O07567; -.
DR STRING; 224308.BSU10560; -.
DR PaxDb; O07567; -.
DR PRIDE; O07567; -.
DR EnsemblBacteria; CAB12896; CAB12896; BSU_10560.
DR GeneID; 936344; -.
DR KEGG; bsu:BSU10560; -.
DR PATRIC; fig|224308.179.peg.1135; -.
DR eggNOG; COG1609; Bacteria.
DR InParanoid; O07567; -.
DR OMA; IVFQTFY; -.
DR PhylomeDB; O07567; -.
DR BioCyc; BSUB:BSU10560-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd01392; HTH_LacI; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..329
FT /note="NTD biosynthesis operon regulator NtdR"
FT /id="PRO_0000107973"
FT DOMAIN 2..56
FT /note="HTH lacI-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT DNA_BIND 4..23
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ SEQUENCE 329 AA; 37687 MW; A1D5252B6A2A20F3 CRC64;
MPTIDEIAKL CNVSKTTVSR VLNNHPYVSK EKRDMILKAI NELDYTPNYL ARNFRRNKTQ
TIALSVPSID HPFFAQLIKG VSHEVLFKNY KVIVFQTFYD KQTELELLEL LKHKEVDGII
LGTLENEWDQ ISPFLKYGPI LLCNEYHHSA DITIIGYDEF EAAYMGVVHL IERGHKKIGF
CFDTPYSEAQ CQRKEGYLKA LQDYNLHHRS EWIFGEMFNI EDGFRVFHKI KDLKDRPSAI
FTGNDQVAAG IIKQAMKNGF KVPEDLAVIG FDNQLICQVV TPTITTIDIP VIELGQQAVL
KIIESISGNA SLNRRIIKLP TKLIIREST
