ID   NTD_LACJO               Reviewed;         149 AA.
AC   Q74LQ9;
DT   13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Nucleoside deoxyribosyltransferase;
DE            Short=N-deoxyribosyltransferase;
DE            EC=2.4.2.6;
GN   Name=ntd; OrderedLocusNames=LJ_0124;
OS   Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=257314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNCM I-1225 / La1 / NCC 533;
RX   PubMed=14983040; DOI=10.1073/pnas.0307327101;
RA   Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C.,
RA   Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R.,
RA   Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
RT   "The genome sequence of the probiotic intestinal bacterium Lactobacillus
RT   johnsonii NCC 533.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
CC   -!- FUNCTION: Catalyzes the cleavage of the glycosidic bond of 2'-
CC       deoxyribonucleosides and the transfer of the deoxyribosyl moiety to an
CC       acceptor purine or pyrimidine base. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-deoxy-D-ribosyl-base(1) + base(2) = 2-deoxy-D-ribosyl-
CC         base(2) + base(1).; EC=2.4.2.6;
CC   -!- PATHWAY: Nucleotide metabolism; nucleotide salvage pathway.
CC   -!- SIMILARITY: Belongs to the nucleoside deoxyribosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AE017198; AAS08106.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q74LQ9; -.
DR   SMR; Q74LQ9; -.
DR   STRING; 257314.LJ_0124; -.
DR   EnsemblBacteria; AAS08106; AAS08106; LJ_0124.
DR   KEGG; ljo:LJ_0124; -.
DR   PATRIC; fig|257314.6.peg.133; -.
DR   eggNOG; COG3613; Bacteria.
DR   HOGENOM; CLU_117644_1_0_9; -.
DR   OMA; IYLAAGW; -.
DR   UniPathway; UPA00312; -.
DR   Proteomes; UP000000581; Chromosome.
DR   GO; GO:0050144; F:nucleoside deoxyribosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0043173; P:nucleotide salvage; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR007710; Nucleoside_deoxyribTrfase.
DR   Pfam; PF05014; Nuc_deoxyrib_tr; 1.
PE   3: Inferred from homology;
KW   Nucleotide metabolism; Reference proteome; Transferase.
FT   CHAIN           1..149
FT                   /note="Nucleoside deoxyribosyltransferase"
FT                   /id="PRO_0000220066"
FT   ACT_SITE        90
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   149 AA;  16941 MW;  6CE8A86B0553152A CRC64;
     MAGWFTETQN KAYKDAMSAL NANPTIDLEN SYVPLQNQYK DIRVDEHPEY LHDKEWAQAT
     YNGDLVGIKT SDVMLGVYVP KEEDVGLGME LGYAMSQGKY VLLVIPDELY GESINLMSWG
     VADNVIKMSE LATFDFNRPR YNFYDGAVY