ID   AROK_PYRFU              Reviewed;         273 AA.
AC   Q8U0A5;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Shikimate kinase {ECO:0000255|HAMAP-Rule:MF_00370};
DE            Short=SK {ECO:0000255|HAMAP-Rule:MF_00370};
DE            EC=2.7.1.71 {ECO:0000255|HAMAP-Rule:MF_00370};
GN   Name=aroK {ECO:0000255|HAMAP-Rule:MF_00370}; OrderedLocusNames=PF1694;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + shikimate = 3-phosphoshikimate + ADP + H(+);
CC         Xref=Rhea:RHEA:13121, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:36208, ChEBI:CHEBI:145989, ChEBI:CHEBI:456216;
CC         EC=2.7.1.71; Evidence={ECO:0000255|HAMAP-Rule:MF_00370};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       5/7. {ECO:0000255|HAMAP-Rule:MF_00370}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00370}.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Archaeal shikimate
CC       kinase subfamily. {ECO:0000255|HAMAP-Rule:MF_00370}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE009950; AAL81818.1; -; Genomic_DNA.
DR   RefSeq; WP_011012840.1; NZ_CP023154.1.
DR   AlphaFoldDB; Q8U0A5; -.
DR   SMR; Q8U0A5; -.
DR   STRING; 186497.PF1694; -.
DR   EnsemblBacteria; AAL81818; AAL81818; PF1694.
DR   GeneID; 41713525; -.
DR   KEGG; pfu:PF1694; -.
DR   PATRIC; fig|186497.12.peg.1762; -.
DR   eggNOG; arCOG01025; Archaea.
DR   HOGENOM; CLU_073768_0_0_2; -.
DR   OMA; WDVLVWT; -.
DR   OrthoDB; 98200at2157; -.
DR   PhylomeDB; Q8U0A5; -.
DR   UniPathway; UPA00053; UER00088.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004765; F:shikimate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.230.10; -; 1.
DR   HAMAP; MF_00370; Shik_kinase_arch; 1.
DR   InterPro; IPR036554; GHMP_kinase_C_sf.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   InterPro; IPR010189; SK_arc.
DR   PANTHER; PTHR20861:SF3; PTHR20861:SF3; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF005758; Shikimt_kin_arch; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55060; SSF55060; 1.
DR   TIGRFAMs; TIGR01920; Shik_kin_archae; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; ATP-binding;
KW   Cytoplasm; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..273
FT                   /note="Shikimate kinase"
FT                   /id="PRO_0000141578"
FT   BINDING         85..95
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00370"
SQ   SEQUENCE   273 AA;  29318 MW;  7551661EB76E09A7 CRC64;
     MRGLGKGSSA ITVVNAFATG KGGAIGIDLW TEAKVKITDG EVKGKILVNG LEFNDFRVVN
     AVLDVMRRYS GIEFGIEFEI NSEIPVGKGL KSSSAVANAL VEAIARALRL NIPGIKVVKL
     GVEAAKKAGV TLTGAFDDAC ASYFGGLCLT DNLRVELLKR IEIDELPVVI LVPNETVLTE
     ELKGVDFLKI APYVEEAFKL AIKGEWKKAL VLNGLIYSTF LSYPPEPISK ALHLGAVVGL
     SGKGPSVFAI TDEPERIEEV WREFGDVIIT STR