NTF2_DICDI
ID NTF2_DICDI Reviewed; 127 AA.
AC Q86HW7; Q551K9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Nuclear transport factor 2 {ECO:0000305};
DE Short=NTF-2;
GN Name=nutf2 {ECO:0000250|UniProtKB:P61970}; ORFNames=DDB_G0276425;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16512674; DOI=10.1021/pr050350q;
RA Reinders Y., Schulz I., Graef R., Sickmann A.;
RT "Identification of novel centrosomal proteins in Dictyostelium discoideum
RT by comparative proteomic approaches.";
RL J. Proteome Res. 5:589-598(2006).
CC -!- FUNCTION: Mediates the import of GDP-bound RAN from the cytoplasm into
CC the nucleus which is essential for the function of RAN in cargo
CC receptor-mediated nucleocytoplasmic transport. Thereby, plays
CC indirectly a more general role in cargo receptor-mediated
CC nucleocytoplasmic transport. Interacts with GDP-bound RAN in the
CC cytosol, recruits it to the nuclear pore complex via its interaction
CC with nucleoporins and promotes its nuclear import.
CC {ECO:0000250|UniProtKB:P61970}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P61970}. Nucleus outer membrane
CC {ECO:0000250|UniProtKB:P61972}. Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:P61972}. Nucleus inner membrane
CC {ECO:0000250|UniProtKB:P61972}. Nucleus, nucleoplasm
CC {ECO:0000250|UniProtKB:P61970}. Note=At steady state it is essentially
CC nucleoplasmic, enriched in nucleoplasmic foci.
CC {ECO:0000250|UniProtKB:P61970}.
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DR EMBL; AAFI02000015; EAL69166.1; -; Genomic_DNA.
DR RefSeq; XP_643125.1; XM_638033.1.
DR AlphaFoldDB; Q86HW7; -.
DR SMR; Q86HW7; -.
DR IntAct; Q86HW7; 1.
DR STRING; 44689.DDB0233957; -.
DR PaxDb; Q86HW7; -.
DR EnsemblProtists; EAL69166; EAL69166; DDB_G0276425.
DR GeneID; 8620530; -.
DR KEGG; ddi:DDB_G0276425; -.
DR dictyBase; DDB_G0276425; nutf2.
DR eggNOG; KOG2104; Eukaryota.
DR HOGENOM; CLU_131642_0_0_1; -.
DR InParanoid; Q86HW7; -.
DR OMA; FTEFYYN; -.
DR PhylomeDB; Q86HW7; -.
DR PRO; PR:Q86HW7; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005635; C:nuclear envelope; ISS:dictyBase.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044613; C:nuclear pore central transport channel; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0031267; F:small GTPase binding; ISS:dictyBase.
DR GO; GO:0017056; F:structural constituent of nuclear pore; ISS:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; ISS:dictyBase.
DR CDD; cd00780; NTF2; 1.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR045875; NTF2/Mtr2.
DR InterPro; IPR002075; NTF2_dom.
DR InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR PANTHER; PTHR12612; PTHR12612; 1.
DR Pfam; PF02136; NTF2; 1.
DR SUPFAM; SSF54427; SSF54427; 1.
DR PROSITE; PS50177; NTF2_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Membrane; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Translocation; Transport.
FT CHAIN 1..127
FT /note="Nuclear transport factor 2"
FT /id="PRO_0000327780"
FT DOMAIN 11..124
FT /note="NTF2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00137"
SQ SEQUENCE 127 AA; 14317 MW; 2D45B1B20021B298 CRC64;
MQSVDPQVVG VGKQFVEHYY GIFDSNRAGL TQIYQQQTTL TWEGKFLSGA DAIVKHIVEL
PFQQTNRKIN SIDCQQTYQP GIMITVTGTL IIDGEAKNQL KFVQVFNLAS NNGSFLLIND
FFRLVLD
