ID   NTF2_KLULA              Reviewed;         125 AA.
AC   Q6CQX4;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Nuclear transport factor 2;
DE            Short=NTF-2;
GN   Name=NTF2; OrderedLocusNames=KLLA0D13508g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Facilitates protein transport into the nucleus. Could be part
CC       of a multicomponent system of cytosolic factors that assemble at the
CC       pore complex during nuclear import (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; CR382124; CAH00761.1; -; Genomic_DNA.
DR   RefSeq; XP_453665.1; XM_453665.1.
DR   AlphaFoldDB; Q6CQX4; -.
DR   SMR; Q6CQX4; -.
DR   STRING; 28985.XP_453665.1; -.
DR   EnsemblFungi; CAH00761; CAH00761; KLLA0_D13508g.
DR   GeneID; 2893416; -.
DR   KEGG; kla:KLLA0_D13508g; -.
DR   eggNOG; KOG2104; Eukaryota.
DR   HOGENOM; CLU_131642_0_0_1; -.
DR   InParanoid; Q6CQX4; -.
DR   OMA; FTEFYYN; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005635; C:nuclear envelope; IEA:EnsemblFungi.
DR   GO; GO:0031267; F:small GTPase binding; IEA:EnsemblFungi.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:EnsemblFungi.
DR   CDD; cd00780; NTF2; 1.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR045875; NTF2/Mtr2.
DR   InterPro; IPR002075; NTF2_dom.
DR   InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR   PANTHER; PTHR12612; PTHR12612; 1.
DR   Pfam; PF02136; NTF2; 1.
DR   SUPFAM; SSF54427; SSF54427; 1.
DR   PROSITE; PS50177; NTF2_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..125
FT                   /note="Nuclear transport factor 2"
FT                   /id="PRO_0000194788"
FT   DOMAIN          8..121
FT                   /note="NTF2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00137"
SQ   SEQUENCE   125 AA;  14405 MW;  9633DDC346D3EE90 CRC64;
     MSVDFSSLAQ QFTEFYYNQF DSDRTQLGNL YREQSMLTFE TTQLQGAKDI VEKLVSLPFQ
     KVAHRITTLD AQPASPNGDV LVMITGDLLI DEEQNPQRFS QVFHLMPEGS SYYVYNDIFR
     LNYSA