ID   NTF2_PONAB              Reviewed;         127 AA.
AC   Q5R8G4; H2NR93;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2016, sequence version 2.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Nuclear transport factor 2 {ECO:0000305};
DE            Short=NTF-2;
GN   Name=NUTF2 {ECO:0000250|UniProtKB:P61970};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the import of GDP-bound RAN from the cytoplasm into
CC       the nucleus which is essential for the function of RAN in cargo
CC       receptor-mediated nucleocytoplasmic transport. Thereby, plays
CC       indirectly a more general role in cargo receptor-mediated
CC       nucleocytoplasmic transport. Interacts with GDP-bound RAN in the
CC       cytosol, recruits it to the nuclear pore complex via its interaction
CC       with nucleoporins and promotes its nuclear import.
CC       {ECO:0000250|UniProtKB:P61970}.
CC   -!- SUBUNIT: Homodimer. Interacts with RAN (GDP-bound form); the
CC       interaction is direct and regulates RAN nuclear import. Interacts with
CC       the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits
CC       NUTF2 to the nuclear pore complex a step required for NUTF2-mediated
CC       GDP-bound RAN nuclear import. Interacts with CAPG; mediates its nuclear
CC       import. {ECO:0000250|UniProtKB:P61970}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P61970}. Nucleus outer membrane
CC       {ECO:0000250|UniProtKB:P61972}. Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:P61972}. Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:P61972}. Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:P61970}. Note=At steady state it is essentially
CC       nucleoplasmic, enriched in nucleoplasmic foci.
CC       {ECO:0000250|UniProtKB:P61970}.
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DR   EMBL; CR859788; CAH91946.1; -; mRNA.
DR   EMBL; ABGA01340709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01340710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001126129.1; NM_001132657.1.
DR   AlphaFoldDB; Q5R8G4; -.
DR   BMRB; Q5R8G4; -.
DR   SMR; Q5R8G4; -.
DR   STRING; 9601.ENSPPYP00000008439; -.
DR   Ensembl; ENSPPYT00000008783; ENSPPYP00000008439; ENSPPYG00000007472.
DR   GeneID; 100173086; -.
DR   KEGG; pon:100173086; -.
DR   CTD; 10204; -.
DR   eggNOG; KOG2104; Eukaryota.
DR   GeneTree; ENSGT00510000047030; -.
DR   InParanoid; Q5R8G4; -.
DR   OMA; FTEFYYN; -.
DR   OrthoDB; 1437819at2759; -.
DR   TreeFam; TF314422; -.
DR   Proteomes; UP000001595; Chromosome 16.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR   GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; ISS:UniProtKB.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006611; P:protein export from nucleus; IEA:Ensembl.
DR   GO; GO:0006606; P:protein import into nucleus; ISS:UniProtKB.
DR   GO; GO:0090204; P:protein localization to nuclear pore; ISS:UniProtKB.
DR   CDD; cd00780; NTF2; 1.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR045875; NTF2/Mtr2.
DR   InterPro; IPR002075; NTF2_dom.
DR   InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR   PANTHER; PTHR12612; PTHR12612; 1.
DR   Pfam; PF02136; NTF2; 1.
DR   SUPFAM; SSF54427; SSF54427; 1.
DR   PROSITE; PS50177; NTF2_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Membrane; mRNA transport; Nuclear pore complex;
KW   Nucleus; Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..127
FT                   /note="Nuclear transport factor 2"
FT                   /id="PRO_0000250701"
FT   DOMAIN          10..121
FT                   /note="NTF2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00137"
FT   MOD_RES         4
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P61970"
FT   CONFLICT        125
FT                   /note="N -> D (in Ref. 1; CAH91946)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   127 AA;  14478 MW;  817752F20E262FD3 CRC64;
     MGDKPIWEQI GSSFIQHYYQ LFDNDRTQLG AIYIDASCLT WEGQQFQGKA AIVEKLSSLP
     FQKIQHSITA QDHQPTPDSC IISMVVGQLK ADEDPIMGFH QMFLLKNIND AWVCTNDMFR
     LALHNFG