ID   NTF2_XENLA              Reviewed;         127 AA.
AC   O42242;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Nuclear transport factor 2;
DE            Short=NTF-2;
DE   AltName: Full=p10;
GN   Name=ntf2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Pu R.T., Shelsta H.N., Dasso M.;
RT   "Identification of a p10(NTF2) homologue in Xenopus.";
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Facilitates protein transport into the nucleus. Interacts
CC       with the nucleoporin p62 and with Ran. Acts at a relatively late stage
CC       of nuclear protein import, subsequent to the initial docking of nuclear
CC       import ligand at the nuclear envelope. Could be part of a
CC       multicomponent system of cytosolic factors that assemble at the pore
CC       complex during nuclear import (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AF023911; AAB81276.1; -; mRNA.
DR   RefSeq; NP_001081710.1; NM_001088241.1.
DR   AlphaFoldDB; O42242; -.
DR   SMR; O42242; -.
DR   DNASU; 398010; -.
DR   GeneID; 398010; -.
DR   KEGG; xla:398010; -.
DR   CTD; 100305281; -.
DR   OrthoDB; 1437819at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 398010; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd00780; NTF2; 1.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR045875; NTF2/Mtr2.
DR   InterPro; IPR002075; NTF2_dom.
DR   InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR   PANTHER; PTHR12612; PTHR12612; 1.
DR   Pfam; PF02136; NTF2; 1.
DR   SUPFAM; SSF54427; SSF54427; 1.
DR   PROSITE; PS50177; NTF2_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..127
FT                   /note="Nuclear transport factor 2"
FT                   /id="PRO_0000194778"
FT   DOMAIN          10..121
FT                   /note="NTF2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00137"
SQ   SEQUENCE   127 AA;  14477 MW;  97110D6828268259 CRC64;
     MAENPIWEQI GASFIQQYYQ TFDADRTQLA VIYTDASCLT WEGQQYHGKA AIVEKLSLLP
     FQKIQHSITS QDHQPTPDSC IISMVVGQLK ADDDPIMGFH QVFLLKNIQD AWVCTNDMFR
     LALHNFG