NTF3_BOVIN
ID NTF3_BOVIN Reviewed; 253 AA.
AC Q08DT3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Neurotrophin-3;
DE Short=NT-3;
DE Flags: Precursor;
GN Name=NTF3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal spinal cord;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR EMBL; BC123576; AAI23577.1; -; mRNA.
DR RefSeq; NP_001071456.1; NM_001077988.2.
DR RefSeq; XP_015326804.1; XM_015471318.1.
DR RefSeq; XP_015326805.1; XM_015471319.1.
DR AlphaFoldDB; Q08DT3; -.
DR SMR; Q08DT3; -.
DR STRING; 9913.ENSBTAP00000040469; -.
DR PaxDb; Q08DT3; -.
DR Ensembl; ENSBTAT00000013493; ENSBTAP00000040469; ENSBTAG00000010223.
DR GeneID; 532393; -.
DR KEGG; bta:532393; -.
DR CTD; 4908; -.
DR VEuPathDB; HostDB:ENSBTAG00000010223; -.
DR VGNC; VGNC:32299; NTF3.
DR eggNOG; ENOG502R4FK; Eukaryota.
DR GeneTree; ENSGT00390000007725; -.
DR HOGENOM; CLU_059942_1_1_1; -.
DR InParanoid; Q08DT3; -.
DR OMA; KQMVDIK; -.
DR OrthoDB; 1156054at2759; -.
DR TreeFam; TF106463; -.
DR Reactome; R-BTA-9034013; NTF3 activates NTRK3 signaling.
DR Reactome; R-BTA-9034793; Activated NTRK3 signals through PLCG1.
DR Reactome; R-BTA-9603381; Activated NTRK3 signals through PI3K.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000010223; Expressed in trachea and 77 other tissues.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0090630; P:activation of GTPase activity; IEA:Ensembl.
DR GO; GO:0032148; P:activation of protein kinase B activity; IEA:Ensembl.
DR GO; GO:0050930; P:induction of positive chemotaxis; IEA:Ensembl.
DR GO; GO:0007613; P:memory; IBA:GO_Central.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR GO; GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0021675; P:nerve development; IBA:GO_Central.
DR GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central.
DR GO; GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0002092; P:positive regulation of receptor internalization; IEA:Ensembl.
DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; PTHR11589; 1.
DR PANTHER; PTHR11589:SF4; PTHR11589:SF4; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..134
FT /evidence="ECO:0000250"
FT /id="PRO_0000321573"
FT CHAIN 135..253
FT /note="Neurotrophin-3"
FT /id="PRO_0000321574"
FT REGION 62..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 148..213
FT /evidence="ECO:0000250"
FT DISULFID 191..242
FT /evidence="ECO:0000250"
FT DISULFID 201..244
FT /evidence="ECO:0000250"
SQ SEQUENCE 253 AA; 28861 MW; D245B08A07ABD78F CRC64;
MSILFYVMFL AYLRGVQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ
STLPKAEAPP REPAKSEFQP VTAMGPELLR QQRRYSSPRV LLSDSTPLEP PPLYLMEDYV
GSPVAANRTS RRKRYAEHKS HRGEYSVCDS ESLWVTDKSS AIDIRGHQVT VLGEIKTGNS
PVKQYFYETR CKEARPVKNG CRGIDDKHWN SQCKTSQTYV RALTSENNKL VGWRWIRIDT
SCVCALSRKI GRT
