ID   NTF3_CALRI              Reviewed;         165 AA.
AC   Q1X6Y0;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Neurotrophin-3;
DE            Short=NT-3;
DE   Flags: Precursor; Fragment;
GN   Name=NTF3;
OS   Calabaria reinhardtii (Calabar boa) (Calabar ground python).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Henophidia; Boidae; Erycinae; Calabaria.
OX   NCBI_TaxID=39283;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16624591; DOI=10.1016/j.ympev.2006.03.010;
RA   Noonan B.P., Chippindale P.T.;
RT   "Dispersal and vicariance: the complex evolutionary history of boid
RT   snakes.";
RL   Mol. Phylogenet. Evol. 40:347-358(2006).
CC   -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC       sensory neurons. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; AY988058; AAY44265.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1X6Y0; -.
DR   SMR; Q1X6Y0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR015578; Neurotrophin-3.
DR   InterPro; IPR045815; NTF3_N.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   PANTHER; PTHR11589:SF4; PTHR11589:SF4; 1.
DR   Pfam; PF00243; NGF; 1.
DR   Pfam; PF19338; NTF3_N; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Glycoprotein; Growth factor; Secreted;
KW   Signal.
FT   SIGNAL          <1..3
FT                   /evidence="ECO:0000255"
FT   PROPEP          4..119
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000346713"
FT   CHAIN           120..>165
FT                   /note="Neurotrophin-3"
FT                   /id="PRO_0000346714"
FT   CARBOHYD        112
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         165
SQ   SEQUENCE   165 AA;  18490 MW;  3CAB0ADA0795BC5B CRC64;
     IQSTSMDQGS LTEDSMNSFI RTLIQAGIWK NKVPKQTART KDGMQTTVKR TKAEAEAVAS
     EGTRLGFQPV VLVDAELLRQ QRRFSSPRVL LSENTPLEPP PLYLMEEPAV LNRTSRRKRY
     AEGKSHRGEY SVCDSESRWV TDKSSAVDIR GHQVTVLGEI RMGPS