NTF3_CEREL
ID NTF3_CEREL Reviewed; 154 AA.
AC Q95150;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Neurotrophin-3;
DE Short=NT-3;
DE Flags: Precursor; Fragment;
GN Name=NTF3;
OS Cervus elaphus (Red deer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Cervidae;
OC Cervinae; Cervus.
OX NCBI_TaxID=9860;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Antler;
RX PubMed=9343309; DOI=10.1677/jme.0.0190173;
RA Garcia R.L., Sadighi M., Francis S.M., Suttie J.M., Fleming J.S.;
RT "Expression of neurotrophin-3 in the growing velvet antler of the red deer
RT Cervus elaphus.";
RL J. Mol. Endocrinol. 19:173-182(1997).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR EMBL; U66715; AAB07024.1; -; mRNA.
DR AlphaFoldDB; Q95150; -.
DR SMR; Q95150; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; PTHR11589; 1.
DR PANTHER; PTHR11589:SF4; PTHR11589:SF4; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Growth factor; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..134
FT /evidence="ECO:0000250"
FT /id="PRO_0000019655"
FT CHAIN 135..>154
FT /note="Neurotrophin-3"
FT /id="PRO_0000019656"
FT NON_TER 154
SQ SEQUENCE 154 AA; 17859 MW; 0EB36CC52E172CCD CRC64;
MSILFYVMFL AYLRGVQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ
STLPKAEDSA RESAKSEFQP VMVMGPELLW YQRRYNSSRF LLSDSIPLES PPLFLIEVHL
ANPMVNSRSP RRKRYAEHKS HRGEYSVCDS ESLW