ID   NTF3_CEREL              Reviewed;         154 AA.
AC   Q95150;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Neurotrophin-3;
DE            Short=NT-3;
DE   Flags: Precursor; Fragment;
GN   Name=NTF3;
OS   Cervus elaphus (Red deer).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Cervidae;
OC   Cervinae; Cervus.
OX   NCBI_TaxID=9860;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Antler;
RX   PubMed=9343309; DOI=10.1677/jme.0.0190173;
RA   Garcia R.L., Sadighi M., Francis S.M., Suttie J.M., Fleming J.S.;
RT   "Expression of neurotrophin-3 in the growing velvet antler of the red deer
RT   Cervus elaphus.";
RL   J. Mol. Endocrinol. 19:173-182(1997).
CC   -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC       sensory neurons.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; U66715; AAB07024.1; -; mRNA.
DR   AlphaFoldDB; Q95150; -.
DR   SMR; Q95150; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR015578; Neurotrophin-3.
DR   InterPro; IPR045815; NTF3_N.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   PANTHER; PTHR11589:SF4; PTHR11589:SF4; 1.
DR   Pfam; PF19338; NTF3_N; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01914; NEUROTROPHN3.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Growth factor; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..134
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000019655"
FT   CHAIN           135..>154
FT                   /note="Neurotrophin-3"
FT                   /id="PRO_0000019656"
FT   NON_TER         154
SQ   SEQUENCE   154 AA;  17859 MW;  0EB36CC52E172CCD CRC64;
     MSILFYVMFL AYLRGVQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ
     STLPKAEDSA RESAKSEFQP VMVMGPELLW YQRRYNSSRF LLSDSIPLES PPLFLIEVHL
     ANPMVNSRSP RRKRYAEHKS HRGEYSVCDS ESLW