ID   NTF3_CHICK              Reviewed;         257 AA.
AC   P25433; Q6LAC6;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 2.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Neurotrophin-3;
DE            Short=NT-3;
DE   AltName: Full=HDNF;
DE   AltName: Full=Nerve growth factor 2;
DE            Short=NGF-2;
DE   AltName: Full=Neurotrophic factor;
DE   Flags: Precursor;
GN   Name=NTF3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1457809; DOI=10.3109/10425179209039695;
RA   Maisonpierre P., Belluscio L., Conover J.C., Yancopoulos G.D.;
RT   "Gene sequences of chicken BDNF and NT-3.";
RL   DNA Seq. 3:49-54(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-257.
RX   PubMed=8074744; DOI=10.1111/j.1460-9568.1993.tb00199.x;
RA   Hallboeoek F., Ibanez C.F., Ebendal T., Persson H.;
RT   "Cellular localization of brain-derived neurotrophic factor and
RT   neurotrophin-3 mRNA expression in the early chicken embryo.";
RL   Eur. J. Neurosci. 5:1-14(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-236.
RX   PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8;
RA   Hallboeoek F., Ibanez C.F., Persson H.;
RT   "Evolutionary studies of the nerve growth factor family reveal a novel
RT   member abundantly expressed in Xenopus ovary.";
RL   Neuron 6:845-858(1991).
CC   -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC       sensory neurons.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: In the embryo, the expression peak at E4.5 and
CC       decreases at later stages of development.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; M83378; AAA68880.1; -; Genomic_DNA.
DR   EMBL; Z30092; CAA82908.1; -; Genomic_DNA.
DR   PIR; I50400; I50400.
DR   RefSeq; NP_001026659.1; NM_001031488.1.
DR   AlphaFoldDB; P25433; -.
DR   SMR; P25433; -.
DR   STRING; 9031.ENSGALP00000043385; -.
DR   PaxDb; P25433; -.
DR   GeneID; 428099; -.
DR   KEGG; gga:428099; -.
DR   CTD; 4908; -.
DR   VEuPathDB; HostDB:geneid_428099; -.
DR   eggNOG; ENOG502R4FK; Eukaryota.
DR   HOGENOM; CLU_059942_1_1_1; -.
DR   InParanoid; P25433; -.
DR   PhylomeDB; P25433; -.
DR   TreeFam; TF106463; -.
DR   PRO; PR:P25433; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0007613; P:memory; IBA:GO_Central.
DR   GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR   GO; GO:0021675; P:nerve development; IBA:GO_Central.
DR   GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR   GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR   GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
DR   GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   InterPro; IPR015578; Neurotrophin-3.
DR   InterPro; IPR045815; NTF3_N.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   PANTHER; PTHR11589:SF4; PTHR11589:SF4; 1.
DR   Pfam; PF00243; NGF; 1.
DR   Pfam; PF19338; NTF3_N; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01914; NEUROTROPHN3.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..138
FT                   /id="PRO_0000019665"
FT   CHAIN           139..257
FT                   /note="Neurotrophin-3"
FT                   /id="PRO_0000019666"
FT   CARBOHYD        131
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        152..217
FT                   /evidence="ECO:0000250"
FT   DISULFID        195..246
FT                   /evidence="ECO:0000250"
FT   DISULFID        205..248
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   257 AA;  29701 MW;  EE043BA2A005C1E7 CRC64;
     MSILFYVIFL AYLRGIQSTN MDQRSLPEDS MNSLIIKLIR ADILKNKLSK QVMDVKENYQ
     NIVQKVEDHQ EMDGDENVKS DFQPVISMDT DLLRQQRRYN SPRVLLSDNT PLEPPPLYLT
     EDYVGSSVVL NRTSRRKRYA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK
     TGNSPVKQYF YETRCKEAKP VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI
     RIDTSCVCAL SRKIGRT