ID   NTF3_FELCA              Reviewed;         257 AA.
AC   Q9TST2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Neurotrophin-3;
DE            Short=NT-3;
DE   AltName: Full=HDNF;
DE   AltName: Full=Nerve growth factor 2;
DE            Short=NGF-2;
DE   AltName: Full=Neurotrophic factor;
DE   Flags: Precursor;
GN   Name=NTF3;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10745216;
RX   DOI=10.1002/(sici)1096-9861(20000424)420:1<1::aid-cne1>3.0.co;2-h;
RA   Lein E.S., Hohn A., Shatz C.J.;
RT   "Dynamic regulation of BDNF and NT-3 expression during visual system
RT   development.";
RL   J. Comp. Neurol. 420:1-18(2000).
CC   -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC       sensory neurons. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; AF192538; AAF03424.1; -; Genomic_DNA.
DR   RefSeq; NP_001009367.1; NM_001009367.1.
DR   AlphaFoldDB; Q9TST2; -.
DR   SMR; Q9TST2; -.
DR   STRING; 9685.ENSFCAP00000006367; -.
DR   GeneID; 493963; -.
DR   KEGG; fca:493963; -.
DR   CTD; 4908; -.
DR   eggNOG; ENOG502R4FK; Eukaryota.
DR   InParanoid; Q9TST2; -.
DR   OrthoDB; 1156054at2759; -.
DR   TreeFam; TF106463; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0007613; P:memory; IBA:GO_Central.
DR   GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR   GO; GO:0021675; P:nerve development; IBA:GO_Central.
DR   GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR   GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR   GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
DR   GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   InterPro; IPR015578; Neurotrophin-3.
DR   InterPro; IPR045815; NTF3_N.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   PANTHER; PTHR11589:SF4; PTHR11589:SF4; 1.
DR   Pfam; PF00243; NGF; 1.
DR   Pfam; PF19338; NTF3_N; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01914; NEUROTROPHN3.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..138
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000019657"
FT   CHAIN           139..257
FT                   /note="Neurotrophin-3"
FT                   /id="PRO_0000019658"
FT   REGION          62..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        131
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        152..217
FT                   /evidence="ECO:0000250"
FT   DISULFID        195..246
FT                   /evidence="ECO:0000250"
FT   DISULFID        205..248
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   257 AA;  29403 MW;  EB53F7E59C5113E4 CRC64;
     MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDLKENYQ
     STLPKAEAPR EPEQGEPAKS EFQPVTAMDT ELLRQQRRYS SPRVLLSDST PLEPPPLYLM
     EDYVGSPVAA NRTSRRKRYA EHKSHRGEYS LCDSESLWVT DKSSAIDIRG HQVTVLGEIK
     SGNSPVKQYF YETRCKEARP VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI
     RIDTSCVCAL SRKIGRT