NTF3_MOUSE
ID NTF3_MOUSE Reviewed; 258 AA.
AC P20181;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Neurotrophin-3;
DE Short=NT-3;
DE AltName: Full=HDNF;
DE AltName: Full=Nerve growth factor 2;
DE Short=NGF-2;
DE AltName: Full=Neurotrophic factor;
DE Flags: Precursor;
GN Name=Ntf3; Synonyms=Ntf-3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2314473; DOI=10.1038/344339a0;
RA Hohn A., Leibrock J., Bailey K., Barde Y.-A.;
RT "Identification and characterization of a novel member of the nerve growth
RT factor/brain-derived neurotrophic factor family.";
RL Nature 344:339-341(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 140-152.
RX PubMed=7957235; DOI=10.1111/j.1432-1033.1994.0995b.x;
RA Kolbeck R., Jungbluth S., Barde Y.-A.;
RT "Characterisation of neurotrophin dimers and monomers.";
RL Eur. J. Biochem. 225:995-1003(1994).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Brain and peripheral tissues.
CC -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR EMBL; X53257; CAA37348.1; -; Genomic_DNA.
DR EMBL; BC065785; AAH65785.1; -; mRNA.
DR CCDS; CCDS20553.1; -.
DR PIR; S09155; S09155.
DR RefSeq; NP_001157506.1; NM_001164034.1.
DR RefSeq; NP_001157507.1; NM_001164035.1.
DR RefSeq; NP_032768.1; NM_008742.3.
DR RefSeq; XP_006505779.1; XM_006505716.2.
DR AlphaFoldDB; P20181; -.
DR SMR; P20181; -.
DR DIP; DIP-5721N; -.
DR STRING; 10090.ENSMUSP00000107863; -.
DR GlyGen; P20181; 1 site.
DR iPTMnet; P20181; -.
DR PhosphoSitePlus; P20181; -.
DR PaxDb; P20181; -.
DR PRIDE; P20181; -.
DR Antibodypedia; 22321; 653 antibodies from 41 providers.
DR DNASU; 18205; -.
DR Ensembl; ENSMUST00000050484; ENSMUSP00000052302; ENSMUSG00000049107.
DR GeneID; 18205; -.
DR KEGG; mmu:18205; -.
DR UCSC; uc012esy.1; mouse.
DR CTD; 4908; -.
DR MGI; MGI:97380; Ntf3.
DR VEuPathDB; HostDB:ENSMUSG00000049107; -.
DR eggNOG; ENOG502R4FK; Eukaryota.
DR GeneTree; ENSGT00390000007725; -.
DR HOGENOM; CLU_059942_1_1_1; -.
DR InParanoid; P20181; -.
DR OMA; KQMVDIK; -.
DR OrthoDB; 1156054at2759; -.
DR PhylomeDB; P20181; -.
DR Reactome; R-MMU-9034013; NTF3 activates NTRK3 signaling.
DR Reactome; R-MMU-9034793; Activated NTRK3 signals through PLCG1.
DR Reactome; R-MMU-9603381; Activated NTRK3 signals through PI3K.
DR BioGRID-ORCS; 18205; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Nutf2; mouse.
DR PRO; PR:P20181; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P20181; protein.
DR Bgee; ENSMUSG00000049107; Expressed in external naris and 192 other tissues.
DR ExpressionAtlas; P20181; baseline and differential.
DR Genevisible; P20181; MM.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; ISO:MGI.
DR GO; GO:0008083; F:growth factor activity; ISO:MGI.
DR GO; GO:0048406; F:nerve growth factor binding; ISO:MGI.
DR GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0005166; F:neurotrophin p75 receptor binding; TAS:MGI.
DR GO; GO:0090630; P:activation of GTPase activity; ISO:MGI.
DR GO; GO:0032148; P:activation of protein kinase B activity; ISO:MGI.
DR GO; GO:0007411; P:axon guidance; IDA:MGI.
DR GO; GO:0007420; P:brain development; IMP:MGI.
DR GO; GO:0048484; P:enteric nervous system development; IMP:MGI.
DR GO; GO:0008544; P:epidermis development; IMP:MGI.
DR GO; GO:0048699; P:generation of neurons; IGI:MGI.
DR GO; GO:0007403; P:glial cell fate determination; IMP:MGI.
DR GO; GO:0050930; P:induction of positive chemotaxis; ISO:MGI.
DR GO; GO:0042490; P:mechanoreceptor differentiation; IGI:MGI.
DR GO; GO:0007613; P:memory; IBA:GO_Central.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; ISO:MGI.
DR GO; GO:0042552; P:myelination; ISO:MGI.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
DR GO; GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; ISO:MGI.
DR GO; GO:0021675; P:nerve development; IMP:MGI.
DR GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; ISO:MGI.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; IDA:MGI.
DR GO; GO:0051402; P:neuron apoptotic process; IMP:MGI.
DR GO; GO:0048666; P:neuron development; IMP:MGI.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR GO; GO:0007422; P:peripheral nervous system development; IMP:MGI.
DR GO; GO:2000251; P:positive regulation of actin cytoskeleton reorganization; ISO:MGI.
DR GO; GO:0030335; P:positive regulation of cell migration; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0045687; P:positive regulation of glial cell differentiation; ISO:MGI.
DR GO; GO:0043406; P:positive regulation of MAP kinase activity; ISO:MGI.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:MGI.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:MGI.
DR GO; GO:0002092; P:positive regulation of receptor internalization; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0042981; P:regulation of apoptotic process; ISO:MGI.
DR GO; GO:0043523; P:regulation of neuron apoptotic process; IDA:MGI.
DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR GO; GO:0051145; P:smooth muscle cell differentiation; IMP:MGI.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISO:MGI.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; PTHR11589; 1.
DR PANTHER; PTHR11589:SF4; PTHR11589:SF4; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Glycoprotein; Growth factor; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..139
FT /evidence="ECO:0000269|PubMed:7957235"
FT /id="PRO_0000019661"
FT CHAIN 140..258
FT /note="Neurotrophin-3"
FT /id="PRO_0000019662"
FT REGION 60..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 131
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 153..218
FT /evidence="ECO:0000250"
FT DISULFID 196..247
FT /evidence="ECO:0000250"
FT DISULFID 206..249
FT /evidence="ECO:0000250"
SQ SEQUENCE 258 AA; 29588 MW; 7180D064E8AE6042 CRC64;
MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ
STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM
EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI
KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW
IRIDTSCVCA LSRKIGRT
