ID   NTF3_XENLA              Reviewed;         260 AA.
AC   P25435;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Neurotrophin-3;
DE            Short=NT-3;
DE   AltName: Full=HDNF;
DE   AltName: Full=Nerve growth factor 2;
DE            Short=NGF-2;
DE   AltName: Full=Neurotrophic factor;
DE   Flags: Precursor;
GN   Name=ntf3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=9096131; DOI=10.1523/jneurosci.17-09-02947.1997;
RA   Xie K., Wang T., Olafsson P., Mizuno K., Lu B.;
RT   "Activity-dependent expression of NT-3 in muscle cells in culture:
RT   implications in the development of neuromuscular junctions.";
RL   J. Neurosci. 17:2947-2958(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 197-217.
RC   TISSUE=Liver;
RX   PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8;
RA   Hallboeoek F., Ibanez C.F., Persson H.;
RT   "Evolutionary studies of the nerve growth factor family reveal a novel
RT   member abundantly expressed in Xenopus ovary.";
RL   Neuron 6:845-858(1991).
CC   -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC       sensory neurons.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U27576; AAB17723.1; -; mRNA.
DR   RefSeq; NP_001084090.1; NM_001090621.1.
DR   AlphaFoldDB; P25435; -.
DR   SMR; P25435; -.
DR   GeneID; 399298; -.
DR   KEGG; xla:399298; -.
DR   CTD; 399298; -.
DR   Xenbase; XB-GENE-17331373; ntf3.L.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 399298; Expressed in camera-type eye and 14 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   InterPro; IPR015578; Neurotrophin-3.
DR   InterPro; IPR045815; NTF3_N.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   PANTHER; PTHR11589:SF4; PTHR11589:SF4; 1.
DR   Pfam; PF00243; NGF; 1.
DR   Pfam; PF19338; NTF3_N; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01914; NEUROTROPHN3.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..141
FT                   /id="PRO_0000019667"
FT   CHAIN           142..260
FT                   /note="Neurotrophin-3"
FT                   /id="PRO_0000019668"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        155..220
FT                   /evidence="ECO:0000250"
FT   DISULFID        198..249
FT                   /evidence="ECO:0000250"
FT   DISULFID        208..251
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   260 AA;  30022 MW;  FFB8507A5EA93CC5 CRC64;
     MSILFYVMFL PYLCGIHATN MDKRNLPENS MNSLFIKLIQ ADLLKNKISK QTVDTKENHQ
     STIPKPQILL DLDGDDNMKQ DFQPVISLEA ELVKQQKQRR YKSPRVLLSD SLPLEPPPLY
     LMDDYIGHST VVNNRTSRRK RFAEHKGHRG EYSVCDSESL WVTDKMNAID IRGHQVTVLG
     EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKMVGW
     RWIRIDTSCV CALSRKIGRS