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NTF4_MOUSE
ID   NTF4_MOUSE              Reviewed;         209 AA.
AC   Q80VU4;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Neurotrophin-4;
DE            Short=NT-4;
DE   AltName: Full=Neurotrophin-5;
DE            Short=NT-5;
DE   AltName: Full=Neutrophic factor 4;
DE   Flags: Precursor;
GN   Name=Ntf4; Synonyms=Ntf5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Limb;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Could serve as a target-derived trophic factor for sensory
CC       and sympathetic neurons. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; BC052191; AAH52191.1; -; mRNA.
DR   CCDS; CCDS21241.1; -.
DR   RefSeq; NP_937833.1; NM_198190.1.
DR   RefSeq; XP_006541375.1; XM_006541312.3.
DR   RefSeq; XP_006541376.1; XM_006541313.2.
DR   RefSeq; XP_011249221.1; XM_011250919.2.
DR   AlphaFoldDB; Q80VU4; -.
DR   SMR; Q80VU4; -.
DR   STRING; 10090.ENSMUSP00000057916; -.
DR   GlyGen; Q80VU4; 1 site.
DR   PhosphoSitePlus; Q80VU4; -.
DR   PaxDb; Q80VU4; -.
DR   PRIDE; Q80VU4; -.
DR   Antibodypedia; 65111; 635 antibodies from 43 providers.
DR   DNASU; 78405; -.
DR   Ensembl; ENSMUST00000058879; ENSMUSP00000057916; ENSMUSG00000074121.
DR   GeneID; 78405; -.
DR   KEGG; mmu:78405; -.
DR   UCSC; uc009gva.1; mouse.
DR   CTD; 78405; -.
DR   MGI; MGI:97381; Ntf5.
DR   VEuPathDB; HostDB:ENSMUSG00000074121; -.
DR   eggNOG; ENOG502R4FK; Eukaryota.
DR   GeneTree; ENSGT00390000007725; -.
DR   HOGENOM; CLU_059942_2_1_1; -.
DR   InParanoid; Q80VU4; -.
DR   OMA; WISECKA; -.
DR   OrthoDB; 1156054at2759; -.
DR   PhylomeDB; Q80VU4; -.
DR   TreeFam; TF106463; -.
DR   Reactome; R-MMU-9026527; Activated NTRK2 signals through PLCG1.
DR   Reactome; R-MMU-9028731; Activated NTRK2 signals through FRS2 and FRS3.
DR   BioGRID-ORCS; 78405; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Ntf5; mouse.
DR   PRO; PR:Q80VU4; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q80VU4; protein.
DR   Bgee; ENSMUSG00000074121; Expressed in manus and 109 other tissues.
DR   ExpressionAtlas; Q80VU4; baseline and differential.
DR   Genevisible; Q80VU4; MM.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0005166; F:neurotrophin p75 receptor binding; TAS:MGI.
DR   GO; GO:0008344; P:adult locomotory behavior; IMP:MGI.
DR   GO; GO:0008544; P:epidermis development; IMP:MGI.
DR   GO; GO:0007402; P:ganglion mother cell fate determination; IMP:MGI.
DR   GO; GO:0060384; P:innervation; IDA:MGI.
DR   GO; GO:0007616; P:long-term memory; IMP:MGI.
DR   GO; GO:0042490; P:mechanoreceptor differentiation; IGI:MGI.
DR   GO; GO:0007613; P:memory; IBA:GO_Central.
DR   GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0060548; P:negative regulation of cell death; IDA:MGI.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR   GO; GO:0021675; P:nerve development; IBA:GO_Central.
DR   GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR   GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR   GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
DR   GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR   GO; GO:0008052; P:sensory organ boundary specification; IMP:MGI.
DR   GO; GO:0061193; P:taste bud development; IDA:MGI.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   InterPro; IPR020432; Neurotrophin-4.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   PANTHER; PTHR11589:SF8; PTHR11589:SF8; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01915; NEUROTROPHN4.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..79
FT                   /id="PRO_0000019671"
FT   CHAIN           80..209
FT                   /note="Neurotrophin-4"
FT                   /id="PRO_0000019672"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        96..169
FT                   /evidence="ECO:0000250"
FT   DISULFID        140..198
FT                   /evidence="ECO:0000250"
FT   DISULFID        157..200
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   209 AA;  22346 MW;  797AE81A2A33EAB6 CRC64;
     MLPRHSCSLL LFLFLLPSVP MEPHPPSSTL PPFLAPEWDL LSPRVALSRG APAGPPLLFL
     LEAGAYGEPA GAPANRSRRG VSETAPASRR GELAVCDAVS GWVTDRRTAV DLRGREVEVL
     GEVPAAGGSP LRQYFFETRC KAESAGEGGP GVGGGGCRGV DRRHWLSECK AKQSYVRALT
     ADSQGRVGWR WIRIDTACVC TLLSRTGRA
 
 
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