NTF4_RAT
ID NTF4_RAT Reviewed; 209 AA.
AC P34131;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Neurotrophin-4;
DE Short=NT-4;
DE AltName: Full=Neurotrophin-5;
DE Short=NT-5;
DE AltName: Full=Neutrophic factor 4;
DE Flags: Precursor;
GN Name=Ntf4; Synonyms=Nt4, Ntf5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1742028; DOI=10.1016/0896-6273(91)90287-a;
RA Berkemeier L.R., Winslow J.W., Kaplan D.R., Nikolics K., Goeddel D.V.,
RA Rosenthal A.;
RT "Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB.";
RL Neuron 7:857-866(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1313578; DOI=10.1073/pnas.89.7.3060;
RA Ip N.Y., Ibanez C.F., Nye S.H., McClain J., Jones P.F., Gies D.R.,
RA Belluscio L., le Beau M.M., Espinosa R. III, Squinto S.P., Persson H.,
RA Yancopoulos G.D.;
RT "Mammalian neurotrophin-4: structure, chromosomal localization, tissue
RT distribution, and receptor specificity.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:3060-3064(1992).
CC -!- FUNCTION: Could serve as a target-derived trophic factor for sensory
CC and sympathetic neurons.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in thymus, muscle, ovary, brain, heart,
CC stomach and kidney. Expressed in both embryo and adult tissues.
CC -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR EMBL; S69323; AAB20548.1; -; mRNA.
DR EMBL; M86742; AAA41728.1; -; Genomic_DNA.
DR PIR; B42687; B42687.
DR RefSeq; NP_037316.2; NM_013184.3.
DR AlphaFoldDB; P34131; -.
DR SMR; P34131; -.
DR STRING; 10116.ENSRNOP00000028195; -.
DR GlyGen; P34131; 1 site.
DR PhosphoSitePlus; P34131; -.
DR PaxDb; P34131; -.
DR Ensembl; ENSRNOT00000028194; ENSRNOP00000028195; ENSRNOG00000020783.
DR Ensembl; ENSRNOT00000095694; ENSRNOP00000093109; ENSRNOG00000020783.
DR GeneID; 25730; -.
DR KEGG; rno:25730; -.
DR UCSC; RGD:3212; rat.
DR CTD; 4909; -.
DR RGD; 3212; Ntf4.
DR eggNOG; ENOG502R4FK; Eukaryota.
DR GeneTree; ENSGT00390000007725; -.
DR HOGENOM; CLU_059942_2_1_1; -.
DR InParanoid; P34131; -.
DR OMA; WISECKA; -.
DR OrthoDB; 1156054at2759; -.
DR PhylomeDB; P34131; -.
DR TreeFam; TF106463; -.
DR Reactome; R-RNO-9026527; Activated NTRK2 signals through PLCG1.
DR Reactome; R-RNO-9028731; Activated NTRK2 signals through FRS2 and FRS3.
DR PRO; PR:P34131; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000020783; Expressed in quadriceps femoris and 11 other tissues.
DR Genevisible; P34131; RN.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008344; P:adult locomotory behavior; ISS:UniProtKB.
DR GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
DR GO; GO:0007402; P:ganglion mother cell fate determination; ISS:UniProtKB.
DR GO; GO:0060384; P:innervation; ISO:RGD.
DR GO; GO:0007616; P:long-term memory; ISS:UniProtKB.
DR GO; GO:0042490; P:mechanoreceptor differentiation; ISO:RGD.
DR GO; GO:0007613; P:memory; IBA:GO_Central.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0060548; P:negative regulation of cell death; ISO:RGD.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR GO; GO:0021675; P:nerve development; IBA:GO_Central.
DR GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR GO; GO:0048167; P:regulation of synaptic plasticity; NAS:RGD.
DR GO; GO:0008052; P:sensory organ boundary specification; ISS:UniProtKB.
DR GO; GO:0061193; P:taste bud development; ISO:RGD.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR020432; Neurotrophin-4.
DR PANTHER; PTHR11589; PTHR11589; 1.
DR PANTHER; PTHR11589:SF8; PTHR11589:SF8; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01915; NEUROTROPHN4.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..79
FT /id="PRO_0000019673"
FT CHAIN 80..209
FT /note="Neurotrophin-4"
FT /id="PRO_0000019674"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..169
FT /evidence="ECO:0000250"
FT DISULFID 140..198
FT /evidence="ECO:0000250"
FT DISULFID 157..200
FT /evidence="ECO:0000250"
FT CONFLICT 177
FT /note="R -> P (in Ref. 2; AAB20548)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 209 AA; 22333 MW; DF5112C05C5D5B85 CRC64;
MLPRHSCSLL LFLLLLPSVP MEPQPPSSTL PPFLAPEWDL LSPRVALSRG TPAGPPLLFL
LEAGAYGEPA GAPANRSRRG VSETAPASRR GELAVCDAVS GWVTDRRTAV DLRGREVEVL
GEVPAAGGSP LRQYFFETRC KAESAGEGGP GVGGGGCRGV DRRHWLSECK AKQSYVRALT
ADSQGRVGWR WIRIDTACVC TLLSRTGRA
