ID   NTF4_XENLA              Reviewed;         236 AA.
AC   P24727;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Neurotrophin-4;
DE            Short=NT-4;
DE   Flags: Precursor;
GN   Name=ntf4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Ovary;
RX   PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8;
RA   Hallboeoek F., Ibanez C.F., Persson H.;
RT   "Evolutionary studies of the nerve growth factor family reveal a novel
RT   member abundantly expressed in Xenopus ovary.";
RL   Neuron 6:845-858(1991).
CC   -!- FUNCTION: NT-4 could play a role in oogenesis and/or early
CC       embryogenesis. NT-4 interacts with the low affinity NGF receptor and
CC       elicits neurite outgrowth from explanted dorsal root ganglia with no
CC       and lower activity in sympathetic and nodose ganglia, respectively.
CC   -!- TISSUE SPECIFICITY: Ovary.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; Z30090; CAA82906.1; -; Genomic_DNA.
DR   PIR; JH0400; JH0400.
DR   AlphaFoldDB; P24727; -.
DR   SMR; P24727; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   InterPro; IPR020432; Neurotrophin-4.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   PANTHER; PTHR11589:SF8; PTHR11589:SF8; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01915; NEUROTROPHN4.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Developmental protein; Differentiation;
KW   Disulfide bond; Glycoprotein; Growth factor; Oogenesis; Reference proteome;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..113
FT                   /id="PRO_0000019675"
FT   CHAIN           114..236
FT                   /note="Neurotrophin-4"
FT                   /id="PRO_0000019676"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        106
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        131..196
FT                   /evidence="ECO:0000250"
FT   DISULFID        174..225
FT                   /evidence="ECO:0000250"
FT   DISULFID        184..227
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   236 AA;  26214 MW;  A210F97F2016357D CRC64;
     MILRLYAMVI SYCCAICAAP FQSRTTDLDY GPDKTSEASD RQSVPNNFSH VLQNGFFPDL
     SSTYSSMAGK DWNLYSPRVT LSSEEPSGPP LLFLSEETVV HPEPANKTSR LKRASGSDSV
     SLSRRGELSV CDSVNVWVTD KRTAVDDRGK IVTVMSEIQT LTGPLKQYFF ETKCNPSGST
     TRGCRGVDKK QWISECKAKQ SYVRALTIDA NKLVGWRWIR IDTACVCTLL SRTGRT