ID   NTF7_CYPCA              Reviewed;         140 AA.
AC   O93474;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Neurotrophin-7;
DE            Short=NT-7;
DE   Flags: Precursor; Fragment;
GN   Name=ntf7; Synonyms=nnt, nt7;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12546061; DOI=10.1006/mcne.1998.0666;
RA   Lai K.-O., Fu W.-Y., Ip F.C.F., Ip N.Y.;
RT   "Cloning and expression of a novel neurotrophin, NT-7, from carp.";
RL   Mol. Cell. Neurosci. 11:64-76(1998).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; U94949; AAC25632.1; -; Genomic_DNA.
DR   AlphaFoldDB; O93474; -.
DR   SMR; O93474; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Growth factor;
KW   Reference proteome; Secreted.
FT   PROPEP          <1..7
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000019679"
FT   CHAIN           8..140
FT                   /note="Neurotrophin-7"
FT                   /id="PRO_0000019680"
FT   DISULFID        21..101
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..129
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..131
FT                   /evidence="ECO:0000250"
FT   VARIANT         70
FT                   /note="I -> V"
FT   VARIANT         95
FT                   /note="E -> K"
FT   NON_TER         1
SQ   SEQUENCE   140 AA;  15855 MW;  3F5E0BCE2601B0FC CRC64;
     PGPRVRRKAN DFLHRGEYSV CDSEEHWVGN LTQATDLRGN EVTVLPHVRI NNVVKKQMFY
     ETTCRVSKPI GAPKPGQGVS GVKAGTSSCR GIDNEHWNSY CTNVHTFVRA LTSYKNQIAW
     RFIRINAACV CVLSRNSWRH