NTF7_DANRE
ID NTF7_DANRE Reviewed; 233 AA.
AC O73797;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Neurotrophin-7;
DE Short=NT-7;
DE Short=zNT-7;
DE Flags: Precursor;
GN Name=ntf7; Synonyms=nt7;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9580190; DOI=10.1016/s0014-5793(98)00192-6;
RA Nilsson A.-S., Fainzilber M., Falck P., Ibanez C.F.;
RT "Neurotrophin-7: a novel member of the neurotrophin family from the
RT zebrafish.";
RL FEBS Lett. 424:285-290(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14572460; DOI=10.1016/s1044-7431(03)00195-7;
RA Dethleffsen K., Heinrich G., Lauth M., Knapik E.W., Meyer M.;
RT "Insert-containing neurotrophins in teleost fish and their relationship to
RT nerve growth factor.";
RL Mol. Cell. Neurosci. 24:380-394(2003).
CC -!- FUNCTION: Recombinant ZNT-7 was able to bind to the human p75
CC neurotrophin receptor/NGFR and to induce tyrosine phosphorylation of
CC the rat NTRK1/TRKA receptor tyrosine kinase, albeit less efficiently
CC than rat NGF. ZNT-7 did not interact with rat NTRK2/TRKB or NTRK3/TRKC,
CC indicating a similar receptor specificity as NGF.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR EMBL; AF055906; AAC41272.1; -; Genomic_DNA.
DR EMBL; AY162426; AAO31816.1; -; mRNA.
DR EMBL; AY162427; AAO31817.1; -; mRNA.
DR EMBL; AY162428; AAO31818.1; -; mRNA.
DR EMBL; AY162429; AAO31819.1; -; mRNA.
DR EMBL; AY162430; AAO31820.1; -; mRNA.
DR EMBL; AY162431; AAO31821.1; -; mRNA.
DR RefSeq; NP_571139.1; NM_131064.3.
DR RefSeq; XP_005161976.1; XM_005161919.3.
DR AlphaFoldDB; O73797; -.
DR SMR; O73797; -.
DR DIP; DIP-6042N; -.
DR STRING; 7955.ENSDARP00000096012; -.
DR PaxDb; O73797; -.
DR Ensembl; ENSDART00000105241; ENSDARP00000096012; ENSDARG00000058961.
DR Ensembl; ENSDART00000137578; ENSDARP00000118931; ENSDARG00000058961.
DR Ensembl; ENSDART00000141196; ENSDARP00000116298; ENSDARG00000058961.
DR Ensembl; ENSDART00000145760; ENSDARP00000120587; ENSDARG00000058961.
DR Ensembl; ENSDART00000147122; ENSDARP00000118680; ENSDARG00000058961.
DR Ensembl; ENSDART00000169978; ENSDARP00000136047; ENSDARG00000058961.
DR Ensembl; ENSDART00000189456; ENSDARP00000156961; ENSDARG00000058961.
DR GeneID; 30270; -.
DR KEGG; dre:30270; -.
DR CTD; 30270; -.
DR ZFIN; ZDB-GENE-990415-176; ngfa.
DR eggNOG; ENOG502RYPU; Eukaryota.
DR GeneTree; ENSGT00390000007725; -.
DR HOGENOM; CLU_059942_1_1_1; -.
DR InParanoid; O73797; -.
DR OMA; SINTWVG; -.
DR OrthoDB; 1156054at2759; -.
DR PhylomeDB; O73797; -.
DR TreeFam; TF106463; -.
DR PRO; PR:O73797; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 23.
DR Bgee; ENSDARG00000058961; Expressed in early embryo and 10 other tissues.
DR ExpressionAtlas; O73797; baseline.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0007613; P:memory; IBA:GO_Central.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR GO; GO:0021675; P:nerve development; IBA:GO_Central.
DR GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central.
DR GO; GO:0048672; P:positive regulation of collateral sprouting; IBA:GO_Central.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589; PTHR11589; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Growth factor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..97
FT /evidence="ECO:0000250"
FT /id="PRO_0000019677"
FT CHAIN 98..233
FT /note="Neurotrophin-7"
FT /id="PRO_0000019678"
FT DISULFID 110..190
FT /evidence="ECO:0000250"
FT DISULFID 153..218
FT /evidence="ECO:0000250"
FT DISULFID 178..220
FT /evidence="ECO:0000250"
SQ SEQUENCE 233 AA; 26423 MW; AD0FCE96DF52C454 CRC64;
MRSLTLVLLI LISIQAALIM GGHTQAQASA NQHAATQNSP RLYSQSKEDL HYDELIPTVD
PKLFNKRRYR SPRVVFSDVI TAEKEMGTPR RPRIRRKAND FLHRGEYSVC DSEEHWVGNL
THATDLGGNE VMVLPHFRIN NVVKKQLFYE TTCRVKKPIG APKPGQGASG VKAGTSSCRG
IDSKHWNSYC TNTHTYVRAL TSYKNQIAWR FIRINAACVC VLSRNSWRHG LKY
