NTM2B_HUMAN
ID NTM2B_HUMAN Reviewed; 878 AA.
AC A6NNL0; A6NM73;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=NUT family member 2B;
GN Name=NUTM2B; Synonyms=FAM22B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6NNL0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NNL0-2; Sequence=VSP_034025, VSP_034026, VSP_034027;
CC -!- SIMILARITY: Belongs to the NUT family. {ECO:0000305}.
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DR EMBL; AL132656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS60574.1; -. [A6NNL0-1]
DR RefSeq; NP_001265424.1; NM_001278495.1. [A6NNL0-1]
DR AlphaFoldDB; A6NNL0; -.
DR BioGRID; 609665; 1.
DR IntAct; A6NNL0; 1.
DR STRING; 9606.ENSP00000394623; -.
DR iPTMnet; A6NNL0; -.
DR PhosphoSitePlus; A6NNL0; -.
DR BioMuta; NUTM2B; -.
DR MassIVE; A6NNL0; -.
DR PaxDb; A6NNL0; -.
DR PeptideAtlas; A6NNL0; -.
DR PRIDE; A6NNL0; -.
DR ProteomicsDB; 1615; -. [A6NNL0-1]
DR Antibodypedia; 70785; 9 antibodies from 5 providers.
DR DNASU; 729262; -.
DR Ensembl; ENST00000372321.6; ENSP00000361396.2; ENSG00000188199.11. [A6NNL0-2]
DR Ensembl; ENST00000429828.6; ENSP00000394623.1; ENSG00000188199.11. [A6NNL0-1]
DR GeneID; 729262; -.
DR KEGG; hsa:729262; -.
DR MANE-Select; ENST00000429828.7; ENSP00000394623.1; NM_001278495.2; NP_001265424.1.
DR UCSC; uc031wmo.1; human. [A6NNL0-1]
DR CTD; 729262; -.
DR DisGeNET; 729262; -.
DR GeneCards; NUTM2B; -.
DR HGNC; HGNC:23445; NUTM2B.
DR HPA; ENSG00000188199; Low tissue specificity.
DR MalaCards; NUTM2B; -.
DR neXtProt; NX_A6NNL0; -.
DR OpenTargets; ENSG00000188199; -.
DR Orphanet; 457246; Clear cell sarcoma of kidney.
DR Orphanet; 213711; Endometrial stromal sarcoma.
DR PharmGKB; PA134908712; -.
DR VEuPathDB; HostDB:ENSG00000188199; -.
DR eggNOG; ENOG502RU0F; Eukaryota.
DR GeneTree; ENSGT00410000025793; -.
DR InParanoid; A6NNL0; -.
DR OMA; QGTERDI; -.
DR OrthoDB; 425279at2759; -.
DR PhylomeDB; A6NNL0; -.
DR TreeFam; TF337728; -.
DR PathwayCommons; A6NNL0; -.
DR BioGRID-ORCS; 729262; 13 hits in 881 CRISPR screens.
DR ChiTaRS; NUTM2B; human.
DR GenomeRNAi; 729262; -.
DR Pharos; A6NNL0; Tdark.
DR PRO; PR:A6NNL0; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; A6NNL0; protein.
DR Bgee; ENSG00000188199; Expressed in cortical plate and 98 other tissues.
DR ExpressionAtlas; A6NNL0; baseline and differential.
DR Genevisible; A6NNL0; HS.
DR InterPro; IPR024310; NUT.
DR InterPro; IPR024309; NUT_N.
DR PANTHER; PTHR22879; PTHR22879; 1.
DR Pfam; PF12881; NUT; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..878
FT /note="NUT family member 2B"
FT /id="PRO_0000337992"
FT REGION 273..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..290
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..448
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..476
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..878
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 617..653
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_034025"
FT VAR_SEQ 657..672
FT /note="ERDVPDPQQGVGMETC -> PSDAPGTDRC (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_034026"
FT VAR_SEQ 673..878
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_034027"
SQ SEQUENCE 878 AA; 93984 MW; AE5AC5B8AA17750D CRC64;
MEVKGPSGRS FCCESEGQFK SCLKRHTPSL LLPSSWKGNS GSCLMAEALH RTSPTPNSCP
LPLPLCRMSG VLCSRNLFTF KFSLFQLDSG ASGEPGHSLG LTLGFSYCGN CQTAVVSAQP
EGMASNGAYP VLGPGVTANP GTSLSVFTAL PFTTPAPGPA HGPLLVTAGA PPGGPLVLST
FPSTPLVTEQ DGCGPSGAGA SNVFVQMRTE VGPVKAAQAQ TLVLTQAPLV WQAPGALCGG
VVCPPPLLLA AAPVVPVMAA QVVGGTQACE GGWSQGLPLP PPPPPAAQLP PIVSQGNAGP
WPQGAHGESS LASSQAKAPP DDSCNPRSVY ENFRLWQHYK PLARRHLPQS PDTEALSCFL
IPVLRSLARR KPTMTLEEGL WRAMREWQHT SNFDRMIFYE MAEKFLEFEA EEEMQIQKSQ
WMKGPQCLPP PATPRLEPRG PPAPEVVKQP VYLPSKAGPK APTACLPPPR PQRPVTKARR
PPPRPHRRAE TKARLPPPRP QRPAETKVPE EIPPEVVQEY VDIMEELLGP SLGATGEPEK
QREEGKVKQP QEEDWTPPDP GLLSYIDKLC SQKDFVTKVE AVIHPQFLEE LLSPDPQMDF
LALSQDLEQE EGLTLAQLVE KRLPPLKEKQ HARAAPSRGT ARLDSSSSKF AAGQGAERDV
PDPQQGVGME TCPPQMTARD SQGRGRAHTG MARSEDSVVL LGCQDSPGLR AAWPTSPPQD
HRPTCPGVGT KDALDLPGGS PVRESHGLAQ GSSEEEELPS LAFLLGSQHK LLPWWLPQSP
VPASGLLSPE KWGPQGTHQS PSAERRGLNL APSPANKAKK RPLFGSLSPA EKTPYPGPGL
RVSGEQSLTW GLGGPSQSQK RKGDPLVSRK EKKQHCSQ
