NTM2D_HUMAN
ID NTM2D_HUMAN Reviewed; 806 AA.
AC Q5VT03; A6NGV9;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=NUT family member 2D;
GN Name=NUTM2D; Synonyms=FAM22D;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
CC -!- SIMILARITY: Belongs to the NUT family. {ECO:0000305}.
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DR EMBL; AL645612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q5VT03; -.
DR IntAct; Q5VT03; 1.
DR BioMuta; NUTM2D; -.
DR DMDM; 190358884; -.
DR jPOST; Q5VT03; -.
DR MassIVE; Q5VT03; -.
DR PeptideAtlas; Q5VT03; -.
DR PRIDE; Q5VT03; -.
DR Ensembl; ENST00000381697.7; ENSP00000371116.1; ENSG00000214562.15.
DR MANE-Select; ENST00000381697.7; ENSP00000371116.1; NM_001382304.1; NP_001369233.1.
DR UCSC; uc001kes.4; human.
DR GeneCards; NUTM2D; -.
DR HGNC; HGNC:23447; NUTM2D.
DR HPA; ENSG00000214562; Low tissue specificity.
DR neXtProt; NX_Q5VT03; -.
DR OpenTargets; ENSG00000214562; -.
DR PharmGKB; PA134912178; -.
DR VEuPathDB; HostDB:ENSG00000214562; -.
DR eggNOG; ENOG502RU0F; Eukaryota.
DR GeneTree; ENSGT00410000025793; -.
DR InParanoid; Q5VT03; -.
DR OMA; YINIMDG; -.
DR PhylomeDB; Q5VT03; -.
DR TreeFam; TF337728; -.
DR PathwayCommons; Q5VT03; -.
DR Pharos; Q5VT03; Tdark.
DR PRO; PR:Q5VT03; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5VT03; protein.
DR Bgee; ENSG00000214562; Expressed in cortical plate and 100 other tissues.
DR ExpressionAtlas; Q5VT03; baseline and differential.
DR Genevisible; Q5VT03; HS.
DR InterPro; IPR024310; NUT.
DR InterPro; IPR024309; NUT_N.
DR PANTHER; PTHR22879; PTHR22879; 1.
DR Pfam; PF12881; NUT; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..806
FT /note="NUT family member 2D"
FT /id="PRO_0000266033"
FT REGION 201..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..218
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..376
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..404
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..806
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 86276 MW; CFC7E6B77349F1C1 CRC64;
MFQEPVYFQI FLFQLDSGAS GEPGHSLGLT LGFSHCGNCQ TAVVSAQPEG MASNGAYPAL
GPGVTANPGT SLSVFTALPF TTPAPGPAHG PLLVTAGAPP GGPLVLSNFP STPLVTEQDG
CGPSGAGASN VFVQMRTEVG PVKAAQAQTL VLTQTPLVWQ APGALCGGVV CPPPLLLAAA
PVVPVMAAQV VGGTQACEGG WSQGLPLPPP PPPAAQLPPI VSQGNAGPWP QGAHGEGSLA
SSQAKAPPDD SCNPRSVYEN FRLWQHYKPL ARRHLPQSPD TEALSCFLIP VLRSLARRKP
TMTLEEGLWR AMREWQHTSN FDRMIFYEMA EKFLEFEAEE EMQIQKSQWM KGPQCLPPPA
TPRLEPRGPP APEVVKQPVY LPSKAGPKAP TACLPPPRPQ RPVTKARRPP PRPHRRAETK
ARLPPPRPQR PAETKVPEEI PPEVVQEYVD IMEELLGPSL GATGEPEKQR EEGEVKQPQE
EDWTPPDPGL LSYTDKLCSQ KDFVTKVEAV IHPQFLEELL SPDPQMDFLA LSQELEQEEG
LTLAQLVEKR LLPLKEKQHA RAAPSRGTAR LDSSSSKFAA GQGAERDVPD PQQGVGMETC
PPQTTARDSQ GRGRAHTGMA RSKDSVVLLG CQDSPGLRAA RPTSPPQDHR PTCPGVGTKD
ALDLPGGSPV RESHGLAQGS SEEEELPSLA FLLGSQHKLL PWWLPQSPVP ASGLLSPEKW
GPQGTHQSPS AERRGLNLAP SPANKAKKRP LFGSLSPAEK TPHPGPGLRV SGEQSLTWGL
GGPSQSQKRK GDPLVSRKEK KQRCSQ
