ID   NTM2E_HUMAN             Reviewed;         878 AA.
AC   B1AL46; A6NHL0;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 3.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=NUT family member 2E;
GN   Name=NUTM2E; Synonyms=FAM22E;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
CC   -!- SIMILARITY: Belongs to the NUT family. {ECO:0000305}.
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DR   EMBL; AL135925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; B1AL46; -.
DR   IntAct; B1AL46; 1.
DR   STRING; 9606.ENSP00000407521; -.
DR   BioMuta; NUTM2E; -.
DR   MassIVE; B1AL46; -.
DR   PaxDb; B1AL46; -.
DR   PeptideAtlas; B1AL46; -.
DR   PRIDE; B1AL46; -.
DR   Ensembl; ENST00000429984.5; ENSP00000407521.2; ENSG00000228570.8.
DR   MANE-Select; ENST00000429984.5; ENSP00000407521.2; NM_001355263.2; NP_001342192.1.
DR   UCSC; uc057umg.1; human.
DR   GeneCards; NUTM2E; -.
DR   HGNC; HGNC:23448; NUTM2E.
DR   HPA; ENSG00000228570; Tissue enhanced (brain).
DR   MalaCards; NUTM2E; -.
DR   neXtProt; NX_B1AL46; -.
DR   OpenTargets; ENSG00000228570; -.
DR   Orphanet; 457246; Clear cell sarcoma of kidney.
DR   PharmGKB; PA134988973; -.
DR   VEuPathDB; HostDB:ENSG00000228570; -.
DR   eggNOG; ENOG502RU0F; Eukaryota.
DR   GeneTree; ENSGT00410000025793; -.
DR   HOGENOM; CLU_021726_0_0_1; -.
DR   InParanoid; B1AL46; -.
DR   OMA; GGTHACE; -.
DR   PhylomeDB; B1AL46; -.
DR   TreeFam; TF337728; -.
DR   PathwayCommons; B1AL46; -.
DR   ChiTaRS; NUTM2E; human.
DR   Pharos; B1AL46; Tdark.
DR   PRO; PR:B1AL46; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; B1AL46; protein.
DR   Bgee; ENSG00000228570; Expressed in stromal cell of endometrium and 95 other tissues.
DR   ExpressionAtlas; B1AL46; baseline and differential.
DR   Genevisible; B1AL46; HS.
DR   InterPro; IPR024310; NUT.
DR   InterPro; IPR024309; NUT_N.
DR   PANTHER; PTHR22879; PTHR22879; 1.
DR   Pfam; PF12881; NUT; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..878
FT                   /note="NUT family member 2E"
FT                   /id="PRO_0000337994"
FT   REGION          273..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          417..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          527..560
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          622..757
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          775..878
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..290
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..321
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        427..448
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..479
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        537..553
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        863..878
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   878 AA;  93979 MW;  C5AE853FD6E57202 CRC64;
     MEVKGPSGRS FCCESEGQFK SCLKRHTPSL LLPSSWKGNS GSCLMAEALH RTSPTPNSCP
     LPLPLCRMSG VLCSRNLFTF KFSLFQLDSG ASGEPGHSLG LTLGFSYCGN CQTAVVSAQP
     EGMASNGAYP VLGPGVTANP GTSLSVFTAL PFTTPAPGPA HGPLLVTAGA PPGGPLVLST
     FPSTPLVTEQ DGCSPSGAGA SNVFVQMRTE VGPVKAAQAQ TLVLTQAPLV WQAPGALCGG
     VVCPPPLLLA AAPVVPVMAA QVVGGTQACE GGWSQGLPLP PPPPPAAQLP PIVSQGNAGP
     WPQGAHGESS LASSQAKAPP DDSCNPRSVY ENFRLWQHYK PLARRHLPQS PDTEALSCFL
     IPVLRSLARR KPTMTLEEGL WRAMREWQHT SNFDRMIFYE MAEKFLEFEA EEEMQIQKSQ
     WMKGPQCLPP PATPRLEPRG PPAPEVVKQP VYLPSKAGPK AQTACLPPPR PQRPVTKARR
     PPPQPHRRAE TKARLPPPRP QRPAETKVPE EIPPEVVQEY VDIMEELLGP SLGATGEPEK
     QREEGKVKQP QEEDWTPPDP GLLSYIDKLC SQKDFVTKVE AVIHPQFLEE LLSPDPQMDF
     LALSQDLEQE EGLTLAQLVE KRLPPLKEKQ HSRAAPSRGT ARLDSSSSKF AAGQGAERDV
     PDPQEGVGME TCPPQTTARD SQGRGRAHTG MARSEDSVVL LGCQDSPGLR AARPTSPPQD
     HRPTCPGVGT KDALDLPGGS PVRESHGLAQ GSSEEEELPS LAFLLGSQHK LLPWWLPQSP
     VPASGLLSPE KWGPQGTHQS PSAERRGLNL APSPANKAKK QPLFGSLSPA EKTPHRGPGL
     RVSGEQSLTW GLGGPSQSQK RKGDPLVSRK EKKQHCSQ