NTM2F_HUMAN
ID NTM2F_HUMAN Reviewed; 756 AA.
AC A1L443; B6ZDF0; Q5SR58; Q5SR59; Q9UFB1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=NUT family member 2F;
GN Name=NUTM2F; Synonyms=FAM22F;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-176.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-755, AND VARIANT GLY-176.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- SIMILARITY: Belongs to the NUT family. {ECO:0000305}.
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DR EMBL; AL691447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC130390; AAI30391.1; -; mRNA.
DR EMBL; AL133071; CAB61394.1; -; mRNA.
DR CCDS; CCDS47994.1; -.
DR PIR; T42671; T42671.
DR RefSeq; NP_060031.1; NM_017561.1.
DR AlphaFoldDB; A1L443; -.
DR BioGRID; 120131; 20.
DR IntAct; A1L443; 25.
DR STRING; 9606.ENSP00000253262; -.
DR iPTMnet; A1L443; -.
DR PhosphoSitePlus; A1L443; -.
DR BioMuta; NUTM2F; -.
DR MassIVE; A1L443; -.
DR PaxDb; A1L443; -.
DR PeptideAtlas; A1L443; -.
DR PRIDE; A1L443; -.
DR Antibodypedia; 68451; 33 antibodies from 7 providers.
DR DNASU; 54754; -.
DR Ensembl; ENST00000253262.9; ENSP00000253262.4; ENSG00000130950.15.
DR GeneID; 54754; -.
DR KEGG; hsa:54754; -.
DR MANE-Select; ENST00000253262.9; ENSP00000253262.4; NM_017561.2; NP_060031.1.
DR UCSC; uc004aup.1; human.
DR CTD; 54754; -.
DR DisGeNET; 54754; -.
DR GeneCards; NUTM2F; -.
DR HGNC; HGNC:23450; NUTM2F.
DR HPA; ENSG00000130950; Tissue enriched (testis).
DR neXtProt; NX_A1L443; -.
DR OpenTargets; ENSG00000130950; -.
DR PharmGKB; PA134981634; -.
DR VEuPathDB; HostDB:ENSG00000130950; -.
DR eggNOG; ENOG502RU0F; Eukaryota.
DR GeneTree; ENSGT00410000025793; -.
DR HOGENOM; CLU_021726_0_0_1; -.
DR InParanoid; A1L443; -.
DR OMA; EPEGQWE; -.
DR OrthoDB; 425279at2759; -.
DR PhylomeDB; A1L443; -.
DR TreeFam; TF337728; -.
DR PathwayCommons; A1L443; -.
DR SignaLink; A1L443; -.
DR BioGRID-ORCS; 54754; 52 hits in 967 CRISPR screens.
DR GenomeRNAi; 54754; -.
DR Pharos; A1L443; Tdark.
DR PRO; PR:A1L443; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; A1L443; protein.
DR Bgee; ENSG00000130950; Expressed in left testis and 8 other tissues.
DR ExpressionAtlas; A1L443; baseline.
DR Genevisible; A1L443; HS.
DR InterPro; IPR024310; NUT.
DR InterPro; IPR024309; NUT_N.
DR PANTHER; PTHR22879; PTHR22879; 1.
DR Pfam; PF12881; NUT; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..756
FT /note="NUT family member 2F"
FT /id="PRO_0000337995"
FT REGION 173..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..325
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..381
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 137
FT /note="S -> C (in dbSNP:rs202099818)"
FT /id="VAR_068009"
FT VARIANT 176
FT /note="R -> G (in dbSNP:rs190275133)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_068010"
FT CONFLICT 126
FT /note="L -> F (in Ref. 2; AAI30391)"
FT /evidence="ECO:0000305"
FT CONFLICT 691
FT /note="Missing (in Ref. 2; AAI30391 and 3; CAB61394)"
FT /evidence="ECO:0000305"
FT CONFLICT 731
FT /note="G -> R (in Ref. 3; CAB61394)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 756 AA; 80770 MW; 51642CA607C736E0 CRC64;
MASNGAYPVL GPGVTVNPGT SLSVFTALPF ATPAPGPAHR PPLVTAVVPP AGPLVLSAFP
STPLVAGQDG RGPSGAGASN VFVQMRTEVG PVKPPQAQTL ILTQAPLVWQ APGTLCGGVM
CPPPLLLAAA PGVPVTSAQV VGGTQACEGG WSHGLPLPPP PPAAQVAPIV SPGNARPWPQ
GAHGEGSLAP SQAKARPDDS CKPKSVYENF RLWQHYKPLA RRHLPQSPDT EALSCFLIPV
LRSLARRKPT MTLEEGLWQA MREWQHTSNF DRMIFYEMAE KFLEFEAEEE MQIQKSQWMK
GPQSLPPPAP PRLEPRGPPA PEVVKQPVYL PSKDGPKAPT ACLPPPRPQR PAETKAHLPP
PRPQRPAETN AHLPPPRPQR PAETKVPEEI PPEVVQEYVD IMEELLGSHP GDTGEPEGQR
EKGKVEQPQE EDGITSDPGL LSYIDKLCSQ EDFVTKVEAV IHPRFLEELL SPDPQMDFLA
LSQELEQEEG LTLAQLVEKR LLSLKEKGCG RAAPRHGTAR LDSSPSEFAA GQEAAREVPD
PQQRVSVETS PPQTAAQDPQ GQGRVRTGMA RSEDPAVLLG CQDSPRLKAV RPTSPPQDHR
PTCPGLGTKD ALGLPGESPV KESHGLAKGS SEETELPGMV YVVGSHHRLR PWRLSQSPVP
SSGLLSPGGR GPQGALQSPS AQKRGLSPSP SPASKSKKRP LFGSPSPAEK TPHPGPGLRV
SGEQSLAWGL GGPSQSQKRK GDPLASRRKK KRHCSQ
