NTM2G_HUMAN
ID NTM2G_HUMAN Reviewed; 741 AA.
AC Q5VZR2; A6NNI5; Q5VZR3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=NUT family member 2G;
GN Name=NUTM2G; Synonyms=FAM22G;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5VZR2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5VZR2-2; Sequence=VSP_034023, VSP_034024;
CC -!- SIMILARITY: Belongs to the NUT family. {ECO:0000305}.
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DR EMBL; AL158827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS43854.1; -. [Q5VZR2-2]
DR CCDS; CCDS55329.1; -. [Q5VZR2-1]
DR RefSeq; NP_001038942.1; NM_001045477.2. [Q5VZR2-2]
DR RefSeq; NP_001164212.1; NM_001170741.1. [Q5VZR2-1]
DR AlphaFoldDB; Q5VZR2; -.
DR BioGRID; 137488; 1.
DR STRING; 9606.ENSP00000361397; -.
DR iPTMnet; Q5VZR2; -.
DR PhosphoSitePlus; Q5VZR2; -.
DR BioMuta; NUTM2G; -.
DR DMDM; 190358885; -.
DR MassIVE; Q5VZR2; -.
DR PaxDb; Q5VZR2; -.
DR PeptideAtlas; Q5VZR2; -.
DR PRIDE; Q5VZR2; -.
DR DNASU; 441457; -.
DR Ensembl; ENST00000354649.7; ENSP00000346670.2; ENSG00000188152.13. [Q5VZR2-2]
DR Ensembl; ENST00000372322.4; ENSP00000361397.3; ENSG00000188152.13. [Q5VZR2-1]
DR GeneID; 441457; -.
DR KEGG; hsa:441457; -.
DR MANE-Select; ENST00000372322.4; ENSP00000361397.3; NM_001170741.3; NP_001164212.1.
DR UCSC; uc004awq.3; human. [Q5VZR2-1]
DR CTD; 441457; -.
DR GeneCards; NUTM2G; -.
DR HGNC; HGNC:23449; NUTM2G.
DR HPA; ENSG00000188152; Tissue enhanced (testis).
DR neXtProt; NX_Q5VZR2; -.
DR OpenTargets; ENSG00000188152; -.
DR PharmGKB; PA134899635; -.
DR VEuPathDB; HostDB:ENSG00000188152; -.
DR eggNOG; ENOG502RU0F; Eukaryota.
DR GeneTree; ENSGT00410000025793; -.
DR HOGENOM; CLU_035677_0_0_1; -.
DR InParanoid; Q5VZR2; -.
DR OMA; PTARINH; -.
DR OrthoDB; 425279at2759; -.
DR PhylomeDB; Q5VZR2; -.
DR TreeFam; TF337728; -.
DR PathwayCommons; Q5VZR2; -.
DR BioGRID-ORCS; 441457; 12 hits in 981 CRISPR screens.
DR GenomeRNAi; 441457; -.
DR Pharos; Q5VZR2; Tdark.
DR PRO; PR:Q5VZR2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5VZR2; protein.
DR Bgee; ENSG00000188152; Expressed in bone marrow cell and 99 other tissues.
DR Genevisible; Q5VZR2; HS.
DR InterPro; IPR024310; NUT.
DR InterPro; IPR024309; NUT_N.
DR PANTHER; PTHR22879; PTHR22879; 1.
DR Pfam; PF12881; NUT; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..741
FT /note="NUT family member 2G"
FT /id="PRO_0000266034"
FT REGION 172..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..325
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..366
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..416
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 481..492
FT /note="LVEKRLLSLKEK -> GAPSDALGTDRC (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_034023"
FT VAR_SEQ 493..741
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_034024"
SQ SEQUENCE 741 AA; 79011 MW; 58DEDDE717F390AE CRC64;
MASNGAYPVL GPGVTVNPGT SLSVFTALPF ATPSPGPTHR PPLVTAVVPP AGPLVLSAFP
STPLVAGQDG RGPSGAGASN VFVQMRTEVG PVKPPQAQTL ILTQAPLVWQ APGTLCGGVM
CPPPLLLAAA PGVPVTSAQV VGGTQACEGG WSHGLPLPPP PPAAQVAPIV SPGNAGPWPQ
GAHGEGSLAP SQAKARPDDS CKPKSVYENF RLWQHYKPLA RRHLPQSPDT EALSCFLIPV
LRSLARRKPT MTLEEGLWRA MREWQHTSNF DRMIFYEMAA KFLEFEAEEE MQIQKSQWMK
GPQSLPPPAP PRLEPRGPPA PEVVKQPVYL PSKDGPKAPT ACLPPPRPQR PAETKAHLPP
PRPPRPAETK VPEEIPPEVV QEYVDIMEEL LGSHPGDTGE PEGQREKGKV EQPQEEDGMT
SDPGLLSYID KLCSQEDFVT KVEAVIHPRF LEELLSPDPQ MDFLALSQEL EQEEGLTLAQ
LVEKRLLSLK EKGCGRAAPR HGTARLDSSP SEFAAGQEAA REVPDPQQRV SVETSPPQTA
AQDPQGQGRV RTGMARSEDP AVLLGCQDSP RLKAVRPTSP PQDHRPTCPG LGTKDALGLP
GESPVKESHG LAKGSSEETE LPGMVYVVGS HHRLRPWRLS QSPVPSSGLL SPGGRGPQGA
LQSPSAQKRG LSPSPSPASK SKKRPLFGSP SPAEKTPHPG PGLRVSGEQS LAWGLGGPSQ
SQKRKGDPLA SRRKKKRHCS Q
