NTPB_ENTHA
ID NTPB_ENTHA Reviewed; 458 AA.
AC Q08637; I6S1L8;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=V-type sodium ATPase subunit B;
DE AltName: Full=Na(+)-translocating ATPase subunit B;
DE AltName: Full=V-type sodium pump subunit B;
GN Name=ntpB; OrderedLocusNames=EHR_08265;
OS Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 /
OS NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=768486;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-25.
RC STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX PubMed=8505293; DOI=10.1016/s0021-9258(19)50245-9;
RA Takase K., Yamato I., Kakinuma Y.;
RT "Cloning and sequencing of the genes coding for the A and B subunits of
RT vacuolar-type Na(+)-ATPase from Enterococcus hirae. Coexistence of
RT vacuolar- and F0F1-type ATPases in one bacterial cell.";
RL J. Biol. Chem. 268:11610-11616(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX PubMed=22933757; DOI=10.1128/jb.01075-12;
RA Gaechter T., Wunderlin C., Schmidheini T., Solioz M.;
RT "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790,
RT a model organism for the study of ion transport, bioenergetics, and copper
RT homeostasis.";
RL J. Bacteriol. 194:5126-5127(2012).
CC -!- FUNCTION: Involved in ATP-driven sodium extrusion.
CC -!- INTERACTION:
CC Q08637; Q08636: ntpA; NbExp=3; IntAct=EBI-16032937, EBI-16032906;
CC -!- INDUCTION: By increasing intracellular Na(+) concentration.
CC -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D13816; BAA02970.1; -; Genomic_DNA.
DR EMBL; D17462; BAA04276.1; -; Genomic_DNA.
DR EMBL; CP003504; AFM70580.1; -; Genomic_DNA.
DR PIR; B46733; B46733.
DR RefSeq; WP_010718636.1; NZ_KB946231.1.
DR PDB; 3VR2; X-ray; 2.80 A; D/E/F=1-458.
DR PDB; 3VR3; X-ray; 3.40 A; D/E/F=1-458.
DR PDB; 3VR4; X-ray; 2.17 A; D/E/F=1-458.
DR PDB; 3VR5; X-ray; 3.90 A; D/E/F=1-458.
DR PDB; 3VR6; X-ray; 2.68 A; D/E/F=1-458.
DR PDB; 5KNB; X-ray; 3.25 A; D/E/F=1-458.
DR PDB; 5KNC; X-ray; 3.02 A; D/E/F=1-458.
DR PDB; 5KND; X-ray; 2.89 A; D/E/F=1-458.
DR PDB; 5ZE9; X-ray; 2.10 A; D/E/F=1-458.
DR PDB; 5ZEA; X-ray; 3.38 A; D/E/F/J/K/L=1-455.
DR PDB; 7COP; X-ray; 2.77 A; D/E/F=1-458.
DR PDB; 7COQ; X-ray; 3.44 A; D/E/F=1-458.
DR PDB; 7COR; X-ray; 2.90 A; D/E/F=1-458.
DR PDB; 7COS; X-ray; 3.95 A; D/E/F/J/K/L=1-458.
DR PDB; 7DQC; X-ray; 2.71 A; D/E/F=1-458.
DR PDB; 7DQD; X-ray; 3.38 A; D/E/F/L/M/N=1-458.
DR PDB; 7DQE; X-ray; 2.69 A; D/E/F=1-458.
DR PDBsum; 3VR2; -.
DR PDBsum; 3VR3; -.
DR PDBsum; 3VR4; -.
DR PDBsum; 3VR5; -.
DR PDBsum; 3VR6; -.
DR PDBsum; 5KNB; -.
DR PDBsum; 5KNC; -.
DR PDBsum; 5KND; -.
DR PDBsum; 5ZE9; -.
DR PDBsum; 5ZEA; -.
DR PDBsum; 7COP; -.
DR PDBsum; 7COQ; -.
DR PDBsum; 7COR; -.
DR PDBsum; 7COS; -.
DR PDBsum; 7DQC; -.
DR PDBsum; 7DQD; -.
DR PDBsum; 7DQE; -.
DR AlphaFoldDB; Q08637; -.
DR SMR; Q08637; -.
DR DIP; DIP-60126N; -.
DR IntAct; Q08637; 1.
DR STRING; 768486.EHR_08265; -.
DR TCDB; 3.A.2.2.2; the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.
DR EnsemblBacteria; AFM70580; AFM70580; EHR_08265.
DR GeneID; 66464791; -.
DR KEGG; ehr:EHR_08265; -.
DR eggNOG; COG1156; Bacteria.
DR HOGENOM; CLU_022916_0_0_9; -.
DR OrthoDB; 875807at2; -.
DR BioCyc; MetaCyc:MON-14147; -.
DR Proteomes; UP000002895; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR HAMAP; MF_00310; ATP_synth_B_arch; 1.
DR InterPro; IPR020003; ATPase_a/bsu_AS.
DR InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR022879; V-ATPase_su_B/beta.
DR PANTHER; PTHR43389; PTHR43389; 1.
DR Pfam; PF00006; ATP-synt_ab; 1.
DR Pfam; PF02874; ATP-synt_ab_N; 1.
DR PIRSF; PIRSF039114; V-ATPsynth_beta/V-ATPase_B; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Ion transport; Sodium;
KW Sodium transport; Transport.
FT CHAIN 1..458
FT /note="V-type sodium ATPase subunit B"
FT /id="PRO_0000144685"
FT STRAND 3..5
FT /evidence="ECO:0007829|PDB:7DQE"
FT STRAND 8..12
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 15..18
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 28..33
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 35..37
FT /evidence="ECO:0007829|PDB:5KNB"
FT STRAND 39..48
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 51..56
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 65..67
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 69..76
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 78..81
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 83..85
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 89..91
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 92..94
FT /evidence="ECO:0007829|PDB:7DQE"
FT STRAND 96..98
FT /evidence="ECO:0007829|PDB:7DQC"
FT STRAND 106..110
FT /evidence="ECO:0007829|PDB:5ZE9"
FT TURN 118..120
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 125..127
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 133..136
FT /evidence="ECO:0007829|PDB:5ZE9"
FT TURN 137..139
FT /evidence="ECO:0007829|PDB:3VR3"
FT STRAND 149..151
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 153..156
FT /evidence="ECO:0007829|PDB:7COR"
FT HELIX 157..167
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 169..172
FT /evidence="ECO:0007829|PDB:7DQE"
FT STRAND 177..186
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 188..201
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 203..206
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 207..213
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 220..237
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 242..248
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 250..263
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 270..272
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 277..285
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 289..291
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 297..305
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 307..309
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 311..313
FT /evidence="ECO:0007829|PDB:5KNB"
FT HELIX 314..320
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 323..329
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 331..335
FT /evidence="ECO:0007829|PDB:5ZE9"
FT TURN 344..346
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 352..355
FT /evidence="ECO:0007829|PDB:5ZE9"
FT TURN 358..360
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 365..389
FT /evidence="ECO:0007829|PDB:5ZE9"
FT TURN 391..393
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 396..411
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 423..434
FT /evidence="ECO:0007829|PDB:5ZE9"
FT STRAND 435..437
FT /evidence="ECO:0007829|PDB:7COP"
FT HELIX 439..441
FT /evidence="ECO:0007829|PDB:5ZE9"
FT HELIX 447..453
FT /evidence="ECO:0007829|PDB:5ZE9"
SQ SEQUENCE 458 AA; 51142 MW; D89D8F2F58B65262 CRC64;
MIKEYRTIKE VVGPLMAVEK VSGVKYEELI EVRMQNGEIR RGQVLEVQED KAMVQIFEGT
SGINLKNSSV RFLGHPLQLG VSEDMIGRVF DGLGRPKDNG PEILPEKYLD INGEVINPIA
RDYPDEFIQT GISAIDHLNT LVRGQKLPVF SGSGLPHKEL AAQIARQATV LDSSDDFAVV
FAAIGITFEE AEFFMEDFRQ TGAIDRSVMF MNLANDPAIE RIATPRMALT AAEYLAYEKG
MHVLVIMTDM TNYAEALREI SAARREVPGR RGYPGYLYTN LATLFERAGR IRGLKGSVTQ
IPILTMPEDD KTHPIPDLTG YITEGQIILT RELYKSGIQP PIDVLPSLSR LKDKGTGAGK
TREDHAATMN QLFAAYAQGK QAKELAVVLG ESALSDIDKI YAKFAERFEN EYVNQGFYTN
RTITETLDLG WELLAMLPRT ELKRIKDDLL DKYLPEGK
